Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00782:Zfp780b'

15000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp780b

Ensembl Gene

ENSMUSG00000063047

Gene Name

zinc finger protein 780B

Synonyms

B230208L21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL00782

Quality Score

Status

Chromosome

Chromosomal Location

27658560-27678596 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27664186 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 123 (D123G)

Ref Sequence

ENSEMBL: ENSMUSP00000146224 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081618] [ENSMUST00000205874] [ENSMUST00000206685]

AlphaFold

E9Q2S6

Predicted Effect

probably benign
Transcript: ENSMUST00000081618
AA Change: D123G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000080324
Gene: ENSMUSG00000063047
AA Change: D123G

Domain	Start	End	E-Value	Type
KRAB	14	75	8.48e-36	SMART
ZnF_C2H2	171	193	2.91e-2	SMART
ZnF_C2H2	199	221	3.44e-4	SMART
ZnF_C2H2	227	249	3.11e-2	SMART
ZnF_C2H2	255	277	2.4e-3	SMART
ZnF_C2H2	283	305	2.15e-5	SMART
ZnF_C2H2	311	333	1.18e-2	SMART
ZnF_C2H2	339	361	1.47e-3	SMART
ZnF_C2H2	367	389	1.79e-2	SMART
ZnF_C2H2	395	417	2.24e-3	SMART
ZnF_C2H2	423	445	7.9e-4	SMART
ZnF_C2H2	451	473	8.34e-3	SMART
ZnF_C2H2	479	501	7.9e-4	SMART
ZnF_C2H2	507	529	3.16e-3	SMART
ZnF_C2H2	535	557	1.58e-3	SMART
ZnF_C2H2	563	585	9.08e-4	SMART
ZnF_C2H2	591	613	1.36e-2	SMART
ZnF_C2H2	619	641	1.04e-3	SMART
ZnF_C2H2	647	669	1.2e-3	SMART
ZnF_C2H2	675	697	2.24e-3	SMART
ZnF_C2H2	703	725	1.03e-2	SMART
ZnF_C2H2	731	753	4.17e-3	SMART
ZnF_C2H2	759	781	1.78e2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205431

Predicted Effect

probably benign
Transcript: ENSMUST00000205874

Predicted Effect

probably benign
Transcript: ENSMUST00000206685
AA Change: D123G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm2	A	T	7: 119,172,391 (GRCm39)	E78V	probably damaging	Het
Atxn7	A	G	14: 14,096,218 (GRCm38)	I508V	possibly damaging	Het
Cecr2	A	G	6: 120,738,582 (GRCm39)	N1075S	probably benign	Het
Clcn3	A	G	8: 61,375,826 (GRCm39)	I689T	probably damaging	Het
Cntnap3	T	C	13: 64,893,619 (GRCm39)		probably benign	Het
Defb11	T	C	8: 22,395,510 (GRCm39)	I56V	probably benign	Het
Ercc5	A	G	1: 44,203,095 (GRCm39)	N244S	probably damaging	Het
Gabrg3	A	G	7: 57,031,415 (GRCm39)	S42P	probably damaging	Het
Hcrtr2	A	T	9: 76,137,779 (GRCm39)		probably benign	Het
Jcad	T	C	18: 4,675,073 (GRCm39)	L945S	probably benign	Het
Lrp2	T	C	2: 69,331,989 (GRCm39)	M1589V	probably benign	Het
Prkg1	C	T	19: 30,556,153 (GRCm39)		probably benign	Het
Samd1	T	C	8: 84,726,246 (GRCm39)	F464S	probably damaging	Het
Slc35b3	A	G	13: 39,127,116 (GRCm39)	S213P	possibly damaging	Het
Taar1	A	G	10: 23,796,344 (GRCm39)	N14S	probably benign	Het
Tinf2	A	G	14: 55,917,921 (GRCm39)		probably null	Het
Utrn	T	C	10: 12,528,555 (GRCm39)	N2140S	probably benign	Het

Other mutations in Zfp780b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03088:Zfp780b	APN	7	27,662,417 (GRCm39)	missense	possibly damaging	0.84
IGL03211:Zfp780b	APN	7	27,662,600 (GRCm39)	missense	possibly damaging	0.93
R0403:Zfp780b	UTSW	7	27,671,114 (GRCm39)	missense	possibly damaging	0.47
R1458:Zfp780b	UTSW	7	27,664,252 (GRCm39)	missense	probably damaging	0.99
R1550:Zfp780b	UTSW	7	27,664,282 (GRCm39)	missense	probably benign
R1694:Zfp780b	UTSW	7	27,663,808 (GRCm39)	missense	possibly damaging	0.86
R1823:Zfp780b	UTSW	7	27,662,525 (GRCm39)	missense	possibly damaging	0.93
R2113:Zfp780b	UTSW	7	27,663,298 (GRCm39)	missense	possibly damaging	0.85
R3086:Zfp780b	UTSW	7	27,663,055 (GRCm39)	missense	probably damaging	0.96
R4620:Zfp780b	UTSW	7	27,662,178 (GRCm39)	nonsense	probably null
R5023:Zfp780b	UTSW	7	27,662,873 (GRCm39)	missense	possibly damaging	0.88
R5521:Zfp780b	UTSW	7	27,674,173 (GRCm39)	splice site	probably null
R5582:Zfp780b	UTSW	7	27,664,252 (GRCm39)	missense	probably damaging	0.99
R5677:Zfp780b	UTSW	7	27,662,224 (GRCm39)	missense	probably benign	0.33
R5762:Zfp780b	UTSW	7	27,664,243 (GRCm39)	missense	probably benign
R5998:Zfp780b	UTSW	7	27,664,047 (GRCm39)	missense	probably benign	0.07
R6036:Zfp780b	UTSW	7	27,662,993 (GRCm39)	missense	probably damaging	0.99
R6036:Zfp780b	UTSW	7	27,662,993 (GRCm39)	missense	probably damaging	0.99
R6050:Zfp780b	UTSW	7	27,663,727 (GRCm39)	missense	probably damaging	0.98
R6702:Zfp780b	UTSW	7	27,671,066 (GRCm39)	missense	possibly damaging	0.91
R6703:Zfp780b	UTSW	7	27,671,066 (GRCm39)	missense	possibly damaging	0.91
R7112:Zfp780b	UTSW	7	27,662,566 (GRCm39)	missense	probably damaging	0.98
R7311:Zfp780b	UTSW	7	27,662,588 (GRCm39)	missense	possibly damaging	0.92
R7469:Zfp780b	UTSW	7	27,663,382 (GRCm39)	missense	probably benign	0.02
R7561:Zfp780b	UTSW	7	27,664,037 (GRCm39)	missense	possibly damaging	0.92
R7847:Zfp780b	UTSW	7	27,663,843 (GRCm39)	missense	probably benign	0.00
R8412:Zfp780b	UTSW	7	27,662,551 (GRCm39)	missense	possibly damaging	0.64
R8824:Zfp780b	UTSW	7	27,662,893 (GRCm39)	missense	probably benign	0.45
R9219:Zfp780b	UTSW	7	27,663,806 (GRCm39)	missense	probably benign	0.24
R9248:Zfp780b	UTSW	7	27,673,143 (GRCm39)	critical splice donor site	probably null
R9642:Zfp780b	UTSW	7	27,664,135 (GRCm39)	missense	probably benign	0.37
X0024:Zfp780b	UTSW	7	27,662,675 (GRCm39)	missense	probably damaging	0.99
Z1186:Zfp780b	UTSW	7	27,664,082 (GRCm39)	missense	probably benign
Z1186:Zfp780b	UTSW	7	27,663,968 (GRCm39)	missense	possibly damaging	0.73
Z1186:Zfp780b	UTSW	7	27,663,250 (GRCm39)	missense	probably benign
Z1186:Zfp780b	UTSW	7	27,674,203 (GRCm39)	missense	probably benign	0.00

Posted On

2012-12-06