Incidental Mutation 'IGL00847:Gm20422'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm20422
Ensembl Gene ENSMUSG00000092544
Gene Namepredicted gene 20422
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00847
Quality Score
Chromosomal Location69742862-69774886 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 69742992 bp
Amino Acid Change Cysteine to Stop codon at position 212 (C212*)
Ref Sequence ENSEMBL: ENSMUSP00000123252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000130458] [ENSMUST00000149782] [ENSMUST00000154063]
Predicted Effect probably benign
Transcript: ENSMUST00000126915
SMART Domains Protein: ENSMUSP00000122850
Gene: ENSMUSG00000092544

KRAB 16 73 1.96e-17 SMART
PDB:2I13|B 104 210 3e-6 PDB
SCOP:d1fgja_ 114 216 2e-6 SMART
Blast:KRAB 189 209 3e-6 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000130458
AA Change: C270*
SMART Domains Protein: ENSMUSP00000119087
Gene: ENSMUSG00000092260
AA Change: C270*

KRAB 4 61 1.96e-17 SMART
ZnF_C2H2 162 184 7.37e1 SMART
ZnF_C2H2 213 235 1.69e-3 SMART
ZnF_C2H2 240 262 8.47e-4 SMART
ZnF_C2H2 268 290 7.15e-2 SMART
ZnF_C2H2 296 318 3.83e-2 SMART
ZnF_C2H2 324 346 4.17e-3 SMART
ZnF_C2H2 352 374 5.99e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000149782
AA Change: C212*
SMART Domains Protein: ENSMUSP00000123252
Gene: ENSMUSG00000092544
AA Change: C212*

KRAB 80 139 1.2e-17 SMART
ZnF_C2H2 155 177 1.69e-3 SMART
ZnF_C2H2 182 204 8.47e-4 SMART
ZnF_C2H2 210 232 7.15e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154063
SMART Domains Protein: ENSMUSP00000117867
Gene: ENSMUSG00000092260

KRAB 4 61 1.96e-17 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 T C 19: 57,152,290 E142G possibly damaging Het
Arid4a C T 12: 71,075,718 P958S probably damaging Het
BC049730 A G 7: 24,714,248 T230A probably benign Het
Cct5 T C 15: 31,590,927 probably benign Het
Cntnap4 C T 8: 112,767,619 probably benign Het
Col4a3 C T 1: 82,717,869 L1597F probably damaging Het
Gla C A X: 134,595,198 V179L probably benign Het
Hace1 T A 10: 45,672,357 Y14* probably null Het
Hcfc2 T A 10: 82,741,278 probably null Het
Helz2 T C 2: 181,232,245 D2152G possibly damaging Het
Mcm8 T G 2: 132,819,674 L74V probably benign Het
Myo18b A G 5: 112,830,389 probably benign Het
Ptprg A T 14: 12,215,265 N1084I probably damaging Het
Rad21l C A 2: 151,660,715 A192S probably benign Het
Scn2a A G 2: 65,670,734 D80G probably damaging Het
Serpinb3c A G 1: 107,276,260 probably null Het
Sgip1 A G 4: 102,928,921 probably benign Het
Slc25a41 G T 17: 57,034,957 probably null Het
Snx14 C A 9: 88,420,329 R140S probably damaging Het
Svs6 A C 2: 164,317,587 K90T possibly damaging Het
Tlcd1 T A 11: 78,180,088 Y168N probably damaging Het
Vps13d A G 4: 145,085,408 I3312T probably benign Het
Zfp11 A G 5: 129,657,914 V161A probably benign Het
Other mutations in Gm20422
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01103:Gm20422 APN 8 69743126 missense possibly damaging 0.71
IGL03326:Gm20422 APN 8 69766698 missense possibly damaging 0.53
R0238:Gm20422 UTSW 8 69766715 missense probably damaging 1.00
Posted On2012-12-06