Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00698:Zfp959'

15018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp959

Ensembl Gene

ENSMUSG00000003198

Gene Name

zinc finger protein 959

Synonyms

BC011426

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL00698

Quality Score

Status

Chromosome

Chromosomal Location

56199093-56205928 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 56204565 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 201 (T201A)

Ref Sequence

ENSEMBL: ENSMUSP00000053979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054780] [ENSMUST00000224379]

AlphaFold

Q91VM8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000054780
AA Change: T201A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000053979
Gene: ENSMUSG00000003198
AA Change: T201A

Domain	Start	End	E-Value	Type
KRAB	4	66	5.28e-14	SMART
ZnF_C2H2	155	177	2.57e2	SMART
ZnF_C2H2	287	309	1.1e-2	SMART
ZnF_C2H2	315	337	4.17e-3	SMART
ZnF_C2H2	343	365	1.47e-3	SMART
ZnF_C2H2	371	393	5.14e-3	SMART
ZnF_C2H2	399	421	1.82e-3	SMART
ZnF_C2H2	427	449	1.98e-4	SMART
ZnF_C2H2	455	477	2.57e-3	SMART
ZnF_C2H2	483	505	7.26e-3	SMART
ZnF_C2H2	511	533	1.72e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224294

Predicted Effect

possibly damaging
Transcript: ENSMUST00000224379
AA Change: T198A

PolyPhen 2 Score 0.649 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 10 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930544G11Rik	T	A	6: 65,929,879 (GRCm39)	V38E	probably damaging	Het
Bbs12	T	C	3: 37,374,943 (GRCm39)	S579P	probably benign	Het
Chd3	A	G	11: 69,240,697 (GRCm39)	S1487P	probably damaging	Het
Cobl	G	T	11: 12,203,722 (GRCm39)	N986K	probably benign	Het
Cpd	T	C	11: 76,731,270 (GRCm39)	E312G	possibly damaging	Het
Fat4	C	A	3: 39,035,294 (GRCm39)	P2982Q	probably benign	Het
Hsf3	A	G	X: 95,382,087 (GRCm39)	I23T	possibly damaging	Het
Mettl25	C	A	10: 105,629,201 (GRCm39)	C487F	probably null	Het
Ranbp17	T	C	11: 33,391,910 (GRCm39)	T34A	probably benign	Het
Zfc3h1	T	C	10: 115,255,737 (GRCm39)	F1463L	possibly damaging	Het

Other mutations in Zfp959

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02731:Zfp959	APN	17	56,202,956 (GRCm39)	splice site	probably benign
IGL03206:Zfp959	APN	17	56,204,613 (GRCm39)	missense	possibly damaging	0.78
R0141:Zfp959	UTSW	17	56,205,139 (GRCm39)	missense	probably benign	0.41
R0347:Zfp959	UTSW	17	56,204,180 (GRCm39)	nonsense	probably null
R0522:Zfp959	UTSW	17	56,203,201 (GRCm39)	missense	probably null	1.00
R1692:Zfp959	UTSW	17	56,205,299 (GRCm39)	missense	probably damaging	0.99
R1771:Zfp959	UTSW	17	56,204,677 (GRCm39)	splice site	probably null
R1891:Zfp959	UTSW	17	56,204,604 (GRCm39)	missense	probably damaging	1.00
R1945:Zfp959	UTSW	17	56,204,231 (GRCm39)	nonsense	probably null
R1959:Zfp959	UTSW	17	56,204,404 (GRCm39)	missense	probably damaging	0.98
R2317:Zfp959	UTSW	17	56,204,326 (GRCm39)	missense	possibly damaging	0.59
R4726:Zfp959	UTSW	17	56,205,260 (GRCm39)	splice site	probably null
R4869:Zfp959	UTSW	17	56,204,228 (GRCm39)	missense	possibly damaging	0.95
R5436:Zfp959	UTSW	17	56,204,626 (GRCm39)	missense	probably benign
R6235:Zfp959	UTSW	17	56,204,427 (GRCm39)	missense	probably damaging	1.00
R6365:Zfp959	UTSW	17	56,204,785 (GRCm39)	missense	probably damaging	1.00
R6391:Zfp959	UTSW	17	56,202,854 (GRCm39)	missense	probably damaging	1.00
R6417:Zfp959	UTSW	17	56,205,094 (GRCm39)	missense	probably damaging	1.00
R6420:Zfp959	UTSW	17	56,205,094 (GRCm39)	missense	probably damaging	1.00
R7114:Zfp959	UTSW	17	56,205,501 (GRCm39)	missense	possibly damaging	0.94
R7380:Zfp959	UTSW	17	56,205,551 (GRCm39)	missense	possibly damaging	0.94
R7437:Zfp959	UTSW	17	56,205,334 (GRCm39)	missense	probably damaging	1.00
R7568:Zfp959	UTSW	17	56,204,886 (GRCm39)	missense	probably benign	0.01
R8114:Zfp959	UTSW	17	56,205,496 (GRCm39)	missense	probably benign	0.09
R8197:Zfp959	UTSW	17	56,204,677 (GRCm39)	missense	probably damaging	1.00
R8389:Zfp959	UTSW	17	56,204,299 (GRCm39)	missense	probably benign
R8970:Zfp959	UTSW	17	56,204,836 (GRCm39)	missense	possibly damaging	0.72
R9063:Zfp959	UTSW	17	56,204,221 (GRCm39)	missense	probably benign	0.18
R9504:Zfp959	UTSW	17	56,204,793 (GRCm39)	missense	probably benign	0.06
R9648:Zfp959	UTSW	17	56,204,212 (GRCm39)	missense	possibly damaging	0.70
R9733:Zfp959	UTSW	17	56,204,866 (GRCm39)	missense	probably benign	0.06
Z1088:Zfp959	UTSW	17	56,205,135 (GRCm39)	missense	probably damaging	0.96

Posted On

2012-12-06