Incidental Mutation 'IGL00801:Zfp961'
| ID |
15019 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp961
|
| Ensembl Gene |
ENSMUSG00000052446 |
| Gene Name |
zinc finger protein 961 |
| Synonyms |
A230105L22Rik, BC049349 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00801
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
72704910-72724177 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 72719732 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Arginine
at position 54
(M54R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148800
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109997]
[ENSMUST00000131237]
[ENSMUST00000132848]
[ENSMUST00000136516]
[ENSMUST00000138304]
[ENSMUST00000145256]
|
| AlphaFold |
E9Q4R5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109997
AA Change: M54R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: M54R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
226 |
248 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
4.61e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131237
AA Change: M35R
PolyPhen 2
Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: M35R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
63 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
125 |
147 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
153 |
175 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
207 |
229 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
235 |
257 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
263 |
285 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
291 |
313 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
319 |
341 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
347 |
369 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
375 |
397 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
4.61e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000132848
AA Change: M54R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: M54R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000136516
AA Change: M54R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
AA Change: M54R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136878
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000138304
AA Change: M54R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139781
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145256
AA Change: M54R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147033
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151168
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144807
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447C04Rik |
T |
C |
12: 72,928,160 (GRCm39) |
T524A |
possibly damaging |
Het |
| Abcb7 |
T |
C |
X: 103,339,584 (GRCm39) |
I562V |
possibly damaging |
Het |
| Anapc4 |
T |
A |
5: 53,014,553 (GRCm39) |
V472D |
probably damaging |
Het |
| Arhgef37 |
A |
G |
18: 61,632,905 (GRCm39) |
Y511H |
probably damaging |
Het |
| Atxn3 |
A |
G |
12: 101,892,767 (GRCm39) |
S316P |
possibly damaging |
Het |
| B3galt1 |
A |
T |
2: 67,948,320 (GRCm39) |
T12S |
possibly damaging |
Het |
| Ccn1 |
T |
A |
3: 145,354,365 (GRCm39) |
D182V |
probably damaging |
Het |
| Cdc14a |
G |
T |
3: 116,088,493 (GRCm39) |
S394* |
probably null |
Het |
| Celsr3 |
T |
C |
9: 108,719,775 (GRCm39) |
V2458A |
probably benign |
Het |
| Dapk1 |
C |
T |
13: 60,909,062 (GRCm39) |
T1225I |
probably benign |
Het |
| Fyb1 |
A |
G |
15: 6,674,305 (GRCm39) |
K647R |
possibly damaging |
Het |
| Gabra5 |
C |
A |
7: 57,138,736 (GRCm39) |
W104L |
probably damaging |
Het |
| Gjb6 |
A |
T |
14: 57,361,498 (GRCm39) |
N254K |
possibly damaging |
Het |
| Golga4 |
T |
A |
9: 118,367,994 (GRCm39) |
L371Q |
probably damaging |
Het |
| Gucy2g |
C |
T |
19: 55,221,535 (GRCm39) |
R322Q |
probably benign |
Het |
| Hnf1b |
C |
T |
11: 83,746,750 (GRCm39) |
A122V |
probably damaging |
Het |
| Insrr |
C |
T |
3: 87,721,115 (GRCm39) |
L1089F |
probably damaging |
Het |
| Knop1 |
A |
G |
7: 118,451,867 (GRCm39) |
V284A |
probably benign |
Het |
| Krt86 |
C |
T |
15: 101,371,741 (GRCm39) |
H104Y |
probably benign |
Het |
| Map1b |
C |
T |
13: 99,566,605 (GRCm39) |
E2039K |
unknown |
Het |
| Myof |
A |
G |
19: 37,974,521 (GRCm39) |
I206T |
probably damaging |
Het |
| Nf1 |
A |
T |
11: 79,319,526 (GRCm39) |
|
probably benign |
Het |
| Nol8 |
A |
G |
13: 49,815,704 (GRCm39) |
D586G |
probably benign |
Het |
| Nudt5 |
T |
C |
2: 5,871,168 (GRCm39) |
F166S |
probably damaging |
Het |
| Ociad1 |
T |
A |
5: 73,461,909 (GRCm39) |
Y87N |
probably damaging |
Het |
| Qtrt2 |
T |
C |
16: 43,701,552 (GRCm39) |
K3E |
probably damaging |
Het |
| Rictor |
G |
A |
15: 6,824,015 (GRCm39) |
V1627I |
probably damaging |
Het |
| Skint2 |
A |
T |
4: 112,483,188 (GRCm39) |
M198L |
possibly damaging |
Het |
| Slitrk5 |
A |
G |
14: 111,918,097 (GRCm39) |
M574V |
probably benign |
Het |
| Thbs1 |
A |
G |
2: 117,953,454 (GRCm39) |
D957G |
probably damaging |
Het |
| Tmem198b |
A |
C |
10: 128,639,014 (GRCm39) |
L43R |
probably damaging |
Het |
| Trpa1 |
A |
G |
1: 14,961,557 (GRCm39) |
M627T |
probably damaging |
Het |
| Zdbf2 |
T |
C |
1: 63,342,197 (GRCm39) |
F192S |
possibly damaging |
Het |
|
| Other mutations in Zfp961 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Zfp961
|
APN |
8 |
72,722,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00825:Zfp961
|
APN |
8 |
72,721,888 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01405:Zfp961
|
APN |
8 |
72,721,778 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03100:Zfp961
|
APN |
8 |
72,721,754 (GRCm39) |
makesense |
probably null |
|
|
R0969:Zfp961
|
UTSW |
8 |
72,722,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Zfp961
|
UTSW |
8 |
72,722,847 (GRCm39) |
unclassified |
probably benign |
|
|
R5502:Zfp961
|
UTSW |
8 |
72,721,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5813:Zfp961
|
UTSW |
8 |
72,722,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Zfp961
|
UTSW |
8 |
72,719,958 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6902:Zfp961
|
UTSW |
8 |
72,722,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7858:Zfp961
|
UTSW |
8 |
72,704,949 (GRCm39) |
missense |
unknown |
|
|
R8749:Zfp961
|
UTSW |
8 |
72,719,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9718:Zfp961
|
UTSW |
8 |
72,721,933 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
X0027:Zfp961
|
UTSW |
8 |
72,721,793 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2012-12-06 |
Incidental Mutation