Incidental Mutation 'IGL00825:Zfp961'
| ID |
15020 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp961
|
| Ensembl Gene |
ENSMUSG00000052446 |
| Gene Name |
zinc finger protein 961 |
| Synonyms |
A230105L22Rik, BC049349 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00825
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
72704910-72724177 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 72721888 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 134
(C134S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109997]
[ENSMUST00000131237]
[ENSMUST00000132848]
[ENSMUST00000136516]
[ENSMUST00000138304]
[ENSMUST00000145256]
|
| AlphaFold |
E9Q4R5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109997
AA Change: C134S
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: C134S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
226 |
248 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
4.61e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131237
AA Change: C115S
PolyPhen 2
Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: C115S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
63 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
125 |
147 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
153 |
175 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
207 |
229 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
235 |
257 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
263 |
285 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
291 |
313 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
319 |
341 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
347 |
369 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
375 |
397 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
4.61e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000132848
AA Change: C134S
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: C134S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136516
|
| SMART Domains |
Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136878
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138304
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139781
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147033
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144807
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151168
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145256
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd3 |
C |
T |
18: 10,704,657 (GRCm39) |
V129M |
probably benign |
Het |
| Casp8 |
G |
A |
1: 58,868,165 (GRCm39) |
S202N |
probably benign |
Het |
| Cimap1c |
A |
G |
9: 56,758,975 (GRCm39) |
I60T |
probably benign |
Het |
| Clec2g |
C |
A |
6: 128,957,144 (GRCm39) |
|
probably null |
Het |
| Dnah7b |
T |
C |
1: 46,263,811 (GRCm39) |
Y2098H |
probably damaging |
Het |
| Dzip3 |
T |
C |
16: 48,748,778 (GRCm39) |
K1053E |
probably damaging |
Het |
| Ern1 |
T |
C |
11: 106,312,793 (GRCm39) |
K196R |
probably benign |
Het |
| Jcad |
A |
T |
18: 4,673,516 (GRCm39) |
Y426F |
probably damaging |
Het |
| Kansl1l |
T |
C |
1: 66,840,671 (GRCm39) |
T210A |
probably benign |
Het |
| Map2k2 |
G |
A |
10: 80,954,052 (GRCm39) |
V173I |
probably benign |
Het |
| P3h2 |
A |
G |
16: 25,811,548 (GRCm39) |
I225T |
probably damaging |
Het |
| Pld2 |
G |
A |
11: 70,442,006 (GRCm39) |
W337* |
probably null |
Het |
| Ppp2r2b |
C |
T |
18: 42,778,840 (GRCm39) |
V429M |
probably damaging |
Het |
| Pprc1 |
G |
T |
19: 46,059,845 (GRCm39) |
|
probably benign |
Het |
| Ptpn4 |
A |
G |
1: 119,587,655 (GRCm39) |
|
probably benign |
Het |
| Rap1gds1 |
T |
A |
3: 138,689,588 (GRCm39) |
I135F |
possibly damaging |
Het |
| Rasa2 |
A |
T |
9: 96,452,772 (GRCm39) |
N371K |
probably benign |
Het |
| Rbbp8 |
A |
G |
18: 11,855,664 (GRCm39) |
T604A |
probably benign |
Het |
| Safb2 |
A |
G |
17: 56,878,208 (GRCm39) |
|
probably null |
Het |
| Sec23ip |
C |
A |
7: 128,369,333 (GRCm39) |
L686I |
probably damaging |
Het |
| Slc22a6 |
T |
C |
19: 8,595,721 (GRCm39) |
V21A |
possibly damaging |
Het |
| Slco1c1 |
A |
T |
6: 141,487,868 (GRCm39) |
N79Y |
probably damaging |
Het |
| Tbl1xr1 |
G |
T |
3: 22,243,950 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Zfp961 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Zfp961
|
APN |
8 |
72,722,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00801:Zfp961
|
APN |
8 |
72,719,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01405:Zfp961
|
APN |
8 |
72,721,778 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03100:Zfp961
|
APN |
8 |
72,721,754 (GRCm39) |
makesense |
probably null |
|
|
R0969:Zfp961
|
UTSW |
8 |
72,722,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Zfp961
|
UTSW |
8 |
72,722,847 (GRCm39) |
unclassified |
probably benign |
|
|
R5502:Zfp961
|
UTSW |
8 |
72,721,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5813:Zfp961
|
UTSW |
8 |
72,722,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Zfp961
|
UTSW |
8 |
72,719,958 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6902:Zfp961
|
UTSW |
8 |
72,722,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7858:Zfp961
|
UTSW |
8 |
72,704,949 (GRCm39) |
missense |
unknown |
|
|
R8749:Zfp961
|
UTSW |
8 |
72,719,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9718:Zfp961
|
UTSW |
8 |
72,721,933 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
X0027:Zfp961
|
UTSW |
8 |
72,721,793 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2012-12-06 |
Incidental Mutation