Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00753:Zmym2'

15039

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym2

Ensembl Gene

ENSMUSG00000021945

Gene Name

zinc finger, MYM-type 2

Synonyms

SCLL, RAMP, Zfp198, FIM, MYM

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.569) question?

Stock #

IGL00753

Quality Score

Status

Chromosome

Chromosomal Location

57123986-57199815 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 57194517 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 1258 (C1258*)

Ref Sequence

ENSEMBL: ENSMUSP00000022511 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022511]

AlphaFold

Q9CU65

Predicted Effect

probably null
Transcript: ENSMUST00000022511
AA Change: C1258*

SMART Domains

Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945
AA Change: C1258*

Domain	Start	End	E-Value	Type
TRASH	330	366	1.55e-5	SMART
TRASH	372	412	7.69e-1	SMART
TRASH	424	459	7.5e1	SMART
TRASH	466	505	6.53e-4	SMART
Pfam:zf-FCS	527	569	1.8e-9	PFAM
TRASH	583	619	4.79e1	SMART
TRASH	638	674	8.49e-3	SMART
TRASH	680	715	7.28e-2	SMART
TRASH	726	761	1.95e-2	SMART
TRASH	767	802	3.89e1	SMART
low complexity region	881	895	N/A	INTRINSIC
low complexity region	904	917	N/A	INTRINSIC
low complexity region	1087	1111	N/A	INTRINSIC
Pfam:DUF3504	1191	1359	7.3e-66	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223965

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224922

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226025

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atad5	C	A	11: 80,023,684 (GRCm39)	Q1596K	probably benign	Het
Bcl9l	C	A	9: 44,416,924 (GRCm39)	T254K	possibly damaging	Het
Cgas	G	A	9: 78,342,770 (GRCm39)	P344L	probably damaging	Het
Csmd3	A	G	15: 47,507,631 (GRCm39)	Y2961H	probably damaging	Het
Dop1b	A	G	16: 93,566,512 (GRCm39)	T980A	probably benign	Het
Gdpd3	C	A	7: 126,366,598 (GRCm39)	Y118*	probably null	Het
Ift140	T	A	17: 25,274,618 (GRCm39)	F763L	probably damaging	Het
Igfn1	G	T	1: 135,894,464 (GRCm39)	P2034H	probably damaging	Het
Msantd2	T	C	9: 37,434,845 (GRCm39)		probably benign	Het
Myo18a	T	C	11: 77,715,977 (GRCm39)	S864P	probably damaging	Het
Plbd1	A	C	6: 136,611,468 (GRCm39)	Y270D	probably benign	Het
Plcl1	T	C	1: 55,735,897 (GRCm39)	S413P	probably damaging	Het
Scn2a	A	G	2: 65,514,207 (GRCm39)	N297S	possibly damaging	Het
Tbc1d17	T	C	7: 44,492,509 (GRCm39)	T385A	probably benign	Het
Thsd7a	C	T	6: 12,327,528 (GRCm39)	C1448Y	probably damaging	Het
Tnpo3	T	A	6: 29,565,786 (GRCm39)	I523F	probably benign	Het
Vps13b	C	T	15: 35,372,177 (GRCm39)	S24L	probably damaging	Het
Wdr37	G	A	13: 8,911,210 (GRCm39)	R18C	probably damaging	Het
Zfyve16	T	A	13: 92,657,626 (GRCm39)	K762*	probably null	Het
Zswim5	T	C	4: 116,842,933 (GRCm39)	W893R	possibly damaging	Het

Other mutations in Zmym2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00516:Zmym2	APN	14	57,185,394 (GRCm39)	splice site	probably benign
IGL00587:Zmym2	APN	14	57,140,817 (GRCm39)	missense	possibly damaging	0.86
IGL00736:Zmym2	APN	14	57,140,668 (GRCm39)	missense	probably benign	0.01
IGL01608:Zmym2	APN	14	57,185,472 (GRCm39)	missense	possibly damaging	0.57
IGL01744:Zmym2	APN	14	57,184,029 (GRCm39)	missense	probably benign	0.24
IGL02150:Zmym2	APN	14	57,148,526 (GRCm39)	splice site	probably benign
IGL02186:Zmym2	APN	14	57,180,808 (GRCm39)	missense	probably benign	0.09
IGL02654:Zmym2	APN	14	57,148,772 (GRCm39)	missense	probably damaging	1.00
IGL02960:Zmym2	APN	14	57,175,870 (GRCm39)	missense	probably benign	0.09
IGL03104:Zmym2	APN	14	57,187,784 (GRCm39)	missense	possibly damaging	0.88
IGL03162:Zmym2	APN	14	57,151,500 (GRCm39)	missense	probably benign	0.24
IGL03356:Zmym2	APN	14	57,194,517 (GRCm39)	nonsense	probably null
IGL03412:Zmym2	APN	14	57,197,176 (GRCm39)	nonsense	probably null
R5038_Zmym2_756	UTSW	14	57,193,637 (GRCm39)	missense	possibly damaging	0.86
R0131:Zmym2	UTSW	14	57,180,715 (GRCm39)	missense	probably benign
R0131:Zmym2	UTSW	14	57,180,715 (GRCm39)	missense	probably benign
R0132:Zmym2	UTSW	14	57,180,715 (GRCm39)	missense	probably benign
R0270:Zmym2	UTSW	14	57,187,141 (GRCm39)	splice site	probably null
R0834:Zmym2	UTSW	14	57,194,420 (GRCm39)	missense	probably damaging	1.00
R1071:Zmym2	UTSW	14	57,197,278 (GRCm39)	missense	possibly damaging	0.93
R1386:Zmym2	UTSW	14	57,150,548 (GRCm39)	missense	probably damaging	1.00
R1442:Zmym2	UTSW	14	57,180,784 (GRCm39)	missense	probably damaging	0.99
R1472:Zmym2	UTSW	14	57,148,640 (GRCm39)	missense	probably benign	0.20
R1595:Zmym2	UTSW	14	57,158,187 (GRCm39)	missense	probably benign	0.25
R1598:Zmym2	UTSW	14	57,151,524 (GRCm39)	missense	probably damaging	1.00
R1598:Zmym2	UTSW	14	57,140,226 (GRCm39)	missense	possibly damaging	0.94
R1916:Zmym2	UTSW	14	57,197,299 (GRCm39)	missense	probably damaging	1.00
R2261:Zmym2	UTSW	14	57,165,719 (GRCm39)	missense	probably damaging	1.00
R2393:Zmym2	UTSW	14	57,158,180 (GRCm39)	missense	probably benign	0.17
R2866:Zmym2	UTSW	14	57,165,705 (GRCm39)	missense	probably damaging	1.00
R3727:Zmym2	UTSW	14	57,156,806 (GRCm39)	splice site	probably benign
R3847:Zmym2	UTSW	14	57,158,956 (GRCm39)	splice site	probably benign
R4043:Zmym2	UTSW	14	57,195,765 (GRCm39)	splice site	probably benign
R4074:Zmym2	UTSW	14	57,140,461 (GRCm39)	missense	probably damaging	0.99
R4343:Zmym2	UTSW	14	57,159,019 (GRCm39)	missense	probably damaging	0.99
R4420:Zmym2	UTSW	14	57,194,335 (GRCm39)	missense	probably damaging	0.98
R4645:Zmym2	UTSW	14	57,165,764 (GRCm39)	missense	probably damaging	1.00
R5015:Zmym2	UTSW	14	57,159,051 (GRCm39)	missense	probably damaging	1.00
R5038:Zmym2	UTSW	14	57,193,637 (GRCm39)	missense	possibly damaging	0.86
R5223:Zmym2	UTSW	14	57,183,971 (GRCm39)	missense	probably benign
R5364:Zmym2	UTSW	14	57,158,102 (GRCm39)	missense	possibly damaging	0.58
R5488:Zmym2	UTSW	14	57,193,712 (GRCm39)	missense	possibly damaging	0.56
R5489:Zmym2	UTSW	14	57,193,712 (GRCm39)	missense	possibly damaging	0.56
R5818:Zmym2	UTSW	14	57,183,986 (GRCm39)	missense	probably benign
R6160:Zmym2	UTSW	14	57,187,766 (GRCm39)	missense	probably damaging	1.00
R6437:Zmym2	UTSW	14	57,140,461 (GRCm39)	missense	probably damaging	1.00
R7107:Zmym2	UTSW	14	57,140,169 (GRCm39)	missense	probably benign	0.01
R7153:Zmym2	UTSW	14	57,187,659 (GRCm39)	missense	probably benign	0.16
R7337:Zmym2	UTSW	14	57,181,557 (GRCm39)	missense	probably benign	0.04
R7535:Zmym2	UTSW	14	57,194,536 (GRCm39)	missense	probably damaging	1.00
R7730:Zmym2	UTSW	14	57,193,638 (GRCm39)	missense	possibly damaging	0.95
R7779:Zmym2	UTSW	14	57,165,740 (GRCm39)	missense	probably damaging	1.00
R7849:Zmym2	UTSW	14	57,184,020 (GRCm39)	missense	probably benign	0.03
R8219:Zmym2	UTSW	14	57,163,316 (GRCm39)	missense	probably benign	0.07
R8493:Zmym2	UTSW	14	57,151,606 (GRCm39)	missense	probably damaging	1.00
R8885:Zmym2	UTSW	14	57,185,329 (GRCm39)	intron	probably benign
R9162:Zmym2	UTSW	14	57,163,361 (GRCm39)	missense	probably benign	0.02
R9165:Zmym2	UTSW	14	57,185,464 (GRCm39)	missense	probably damaging	0.98
R9250:Zmym2	UTSW	14	57,148,732 (GRCm39)	missense	probably damaging	1.00
R9453:Zmym2	UTSW	14	57,180,770 (GRCm39)	missense	probably damaging	1.00
R9677:Zmym2	UTSW	14	57,187,115 (GRCm39)	missense	probably benign	0.01
Z1176:Zmym2	UTSW	14	57,150,456 (GRCm39)	missense	possibly damaging	0.94
Z1177:Zmym2	UTSW	14	57,151,419 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06