Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00707:Zzz3'

15062

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zzz3

Ensembl Gene

ENSMUSG00000039068

Gene Name

zinc finger, ZZ domain containing 3

Synonyms

6430567E01Rik, 3110065C23Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00707

Quality Score

Status

Chromosome

Chromosomal Location

152101110-152168463 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 152154680 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 118 (L118*)

Ref Sequence

ENSEMBL: ENSMUSP00000143693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]

AlphaFold

Q6KAQ7

Predicted Effect

probably null
Transcript: ENSMUST00000089982
AA Change: L614*

SMART Domains

Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068
AA Change: L614*

Domain	Start	End	E-Value	Type
SANT	657	711	1.42e-9	SMART
low complexity region	776	787	N/A	INTRINSIC
low complexity region	799	814	N/A	INTRINSIC
ZnF_ZZ	823	871	6.46e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000106100
AA Change: L615*

SMART Domains

Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068
AA Change: L615*

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000106101
AA Change: L615*

SMART Domains

Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068
AA Change: L615*

Domain	Start	End	E-Value	Type
SANT	658	712	1.42e-9	SMART
low complexity region	777	788	N/A	INTRINSIC
low complexity region	800	815	N/A	INTRINSIC
ZnF_ZZ	824	872	6.46e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000106103
AA Change: L114*

SMART Domains

Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068
AA Change: L114*

Domain	Start	End	E-Value	Type
SANT	157	211	1.42e-9	SMART
low complexity region	276	287	N/A	INTRINSIC
low complexity region	299	314	N/A	INTRINSIC
ZnF_ZZ	323	371	6.46e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150802

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197987

Predicted Effect

probably null
Transcript: ENSMUST00000200570
AA Change: L118*

SMART Domains

Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068
AA Change: L118*

Domain	Start	End	E-Value	Type
SANT	161	215	1.42e-9	SMART
low complexity region	280	291	N/A	INTRINSIC
low complexity region	303	318	N/A	INTRINSIC
ZnF_ZZ	327	375	6.46e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 13 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D14Rik	G	T	11: 72,069,330 (GRCm39)	T528K	probably damaging	Het
Abca13	A	T	11: 9,241,586 (GRCm39)	T1150S	probably damaging	Het
Acrv1	C	T	9: 36,607,904 (GRCm39)	T188I	possibly damaging	Het
Atrnl1	A	T	19: 57,661,697 (GRCm39)	Y559F	probably damaging	Het
Ccdc171	A	T	4: 83,599,392 (GRCm39)	M736L	probably benign	Het
Eif4g1	G	A	16: 20,507,764 (GRCm39)	R1480Q	probably damaging	Het
Huwe1	T	A	X: 150,643,730 (GRCm39)	S553T	probably damaging	Het
Myb	T	A	10: 21,024,283 (GRCm39)	E299V	probably damaging	Het
Nuf2	T	A	1: 169,350,004 (GRCm39)		probably benign	Het
Ptafr	A	G	4: 132,307,569 (GRCm39)	T320A	probably benign	Het
Pwp1	T	A	10: 85,714,380 (GRCm39)	H107Q	probably damaging	Het
Tmeff2	A	G	1: 51,172,212 (GRCm39)		probably null	Het
Zp2	C	T	7: 119,732,636 (GRCm39)	A637T	probably benign	Het

Other mutations in Zzz3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00691:Zzz3	APN	3	152,134,151 (GRCm39)	missense	probably benign	0.16
IGL00983:Zzz3	APN	3	152,161,447 (GRCm39)	splice site	probably benign
IGL01586:Zzz3	APN	3	152,161,476 (GRCm39)	missense	possibly damaging	0.80
IGL01973:Zzz3	APN	3	152,134,007 (GRCm39)	missense	probably benign	0.00
IGL02002:Zzz3	APN	3	152,157,006 (GRCm39)	missense	probably damaging	0.98
IGL02009:Zzz3	APN	3	152,133,752 (GRCm39)	missense	possibly damaging	0.80
IGL02260:Zzz3	APN	3	152,157,720 (GRCm39)	missense	probably benign	0.04
IGL02336:Zzz3	APN	3	152,133,696 (GRCm39)	missense	possibly damaging	0.74
IGL02454:Zzz3	APN	3	152,134,211 (GRCm39)	missense	probably benign	0.03
IGL02519:Zzz3	APN	3	152,133,027 (GRCm39)	missense	probably damaging	1.00
R0067:Zzz3	UTSW	3	152,134,040 (GRCm39)	missense	possibly damaging	0.88
R0067:Zzz3	UTSW	3	152,134,040 (GRCm39)	missense	possibly damaging	0.88
R0314:Zzz3	UTSW	3	152,133,085 (GRCm39)	missense	probably benign	0.00
R0536:Zzz3	UTSW	3	152,154,465 (GRCm39)	missense	probably damaging	1.00
R1706:Zzz3	UTSW	3	152,154,735 (GRCm39)	missense	probably damaging	1.00
R2869:Zzz3	UTSW	3	152,152,481 (GRCm39)	synonymous	silent
R2870:Zzz3	UTSW	3	152,152,481 (GRCm39)	synonymous	silent
R2871:Zzz3	UTSW	3	152,152,481 (GRCm39)	synonymous	silent
R2872:Zzz3	UTSW	3	152,152,481 (GRCm39)	synonymous	silent
R3927:Zzz3	UTSW	3	152,161,499 (GRCm39)	missense	probably damaging	1.00
R4195:Zzz3	UTSW	3	152,134,102 (GRCm39)	missense	probably benign	0.02
R4768:Zzz3	UTSW	3	152,154,420 (GRCm39)	missense	probably damaging	1.00
R5248:Zzz3	UTSW	3	152,133,182 (GRCm39)	missense	probably damaging	0.99
R5566:Zzz3	UTSW	3	152,161,461 (GRCm39)	missense	probably damaging	1.00
R5752:Zzz3	UTSW	3	152,157,759 (GRCm39)	missense	possibly damaging	0.48
R5782:Zzz3	UTSW	3	152,133,737 (GRCm39)	missense	possibly damaging	0.69
R5884:Zzz3	UTSW	3	152,156,295 (GRCm39)	missense	probably damaging	1.00
R6008:Zzz3	UTSW	3	152,133,788 (GRCm39)	missense	probably benign	0.01
R6155:Zzz3	UTSW	3	152,133,319 (GRCm39)	missense	possibly damaging	0.57
R6557:Zzz3	UTSW	3	152,134,097 (GRCm39)	missense	probably damaging	1.00
R6865:Zzz3	UTSW	3	152,133,690 (GRCm39)	missense	probably benign	0.01
R7344:Zzz3	UTSW	3	152,157,736 (GRCm39)	missense	probably damaging	0.98
R7588:Zzz3	UTSW	3	152,128,405 (GRCm39)	missense	possibly damaging	0.85
R7636:Zzz3	UTSW	3	152,133,289 (GRCm39)	missense	probably benign
R7732:Zzz3	UTSW	3	152,154,479 (GRCm39)	missense	probably damaging	1.00
R8157:Zzz3	UTSW	3	152,155,285 (GRCm39)	missense	probably null	0.71
R8490:Zzz3	UTSW	3	152,134,290 (GRCm39)	nonsense	probably null
R8926:Zzz3	UTSW	3	152,133,529 (GRCm39)	missense	possibly damaging	0.76
R9143:Zzz3	UTSW	3	152,163,908 (GRCm39)	missense	probably benign	0.04
R9243:Zzz3	UTSW	3	152,133,920 (GRCm39)	missense	probably damaging	1.00
R9494:Zzz3	UTSW	3	152,133,468 (GRCm39)	missense	possibly damaging	0.88
R9540:Zzz3	UTSW	3	152,156,306 (GRCm39)	nonsense	probably null
X0018:Zzz3	UTSW	3	152,134,370 (GRCm39)	missense	possibly damaging	0.88
Z1176:Zzz3	UTSW	3	152,154,734 (GRCm39)	missense	possibly damaging	0.94

Posted On

2012-12-06