Incidental Mutation 'R1288:Or2n1e'
ID 150686
Institutional Source Beutler Lab
Gene Symbol Or2n1e
Ensembl Gene ENSMUSG00000057443
Gene Name olfactory receptor family 2 subfamily N member 1E
Synonyms MOR256-40P, Olfr138, Olfr89, GA_x6K02T2PSCP-2718585-2719523
MMRRC Submission 039354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R1288 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38585664-38586602 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38586114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 151 (T151A)
Ref Sequence ENSEMBL: ENSMUSP00000133828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071871] [ENSMUST00000172843] [ENSMUST00000173841]
AlphaFold Q7TRI7
Predicted Effect probably benign
Transcript: ENSMUST00000071871
AA Change: T151A

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000071767
Gene: ENSMUSG00000057443
AA Change: T151A

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 2.4e-33 PFAM
Pfam:7tm_4 139 283 8.1e-41 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172843
AA Change: T151A

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000133698
Gene: ENSMUSG00000057443
AA Change: T151A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-46 PFAM
Pfam:7tm_1 41 290 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173841
AA Change: T151A

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000133828
Gene: ENSMUSG00000057443
AA Change: T151A

DomainStartEndE-ValueType
Pfam:7tm_1 41 123 1.7e-15 PFAM
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrd1 A T 5: 129,206,071 (GRCm39) D247V probably damaging Het
Ano5 A T 7: 51,196,620 (GRCm39) S184C probably damaging Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Atxn3 C T 12: 101,908,437 (GRCm39) probably null Het
BC005537 A T 13: 24,988,883 (GRCm39) E54V probably damaging Het
Ccdc150 A T 1: 54,403,617 (GRCm39) E881V probably damaging Het
Cep126 A T 9: 8,112,182 (GRCm39) N130K probably benign Het
Enoph1 A G 5: 100,188,138 (GRCm39) T21A possibly damaging Het
Fbxw28 A G 9: 109,166,361 (GRCm39) I165T probably damaging Het
Lrp12 A T 15: 39,741,799 (GRCm39) N305K probably damaging Het
Msl2 A G 9: 100,979,308 (GRCm39) T561A probably benign Het
Mup21 G T 4: 62,068,934 (GRCm39) A19E probably benign Het
Myh13 T C 11: 67,244,544 (GRCm39) I1027T probably benign Het
Nkg7 A G 7: 43,087,086 (GRCm39) probably null Het
Nme8 A G 13: 19,858,619 (GRCm39) V73A possibly damaging Het
Or2g1 T A 17: 38,106,584 (GRCm39) L83Q probably damaging Het
Or52a5 A T 7: 103,427,249 (GRCm39) L101Q possibly damaging Het
Or5w12 G A 2: 87,501,916 (GRCm39) A265V probably benign Het
Or6c69c A G 10: 129,911,154 (GRCm39) N292D probably damaging Het
Rapgef3 C A 15: 97,657,223 (GRCm39) S267I probably benign Het
Trhde T A 10: 114,637,195 (GRCm39) D4V probably benign Het
Vmn1r234 CTT CTTT 17: 21,449,513 (GRCm39) probably null Het
Zfp40 T A 17: 23,401,136 (GRCm39) I36L probably benign Het
Other mutations in Or2n1e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Or2n1e APN 17 38,585,790 (GRCm39) missense probably benign 0.01
IGL01874:Or2n1e APN 17 38,586,408 (GRCm39) missense probably benign 0.32
IGL02209:Or2n1e APN 17 38,586,123 (GRCm39) missense probably benign 0.00
IGL03053:Or2n1e APN 17 38,585,682 (GRCm39) missense probably damaging 0.96
IGL03168:Or2n1e APN 17 38,585,682 (GRCm39) missense probably damaging 0.96
R0393:Or2n1e UTSW 17 38,585,774 (GRCm39) missense probably benign 0.00
R0667:Or2n1e UTSW 17 38,586,048 (GRCm39) missense probably damaging 1.00
R1567:Or2n1e UTSW 17 38,586,459 (GRCm39) missense possibly damaging 0.87
R1618:Or2n1e UTSW 17 38,586,557 (GRCm39) splice site probably null
R1699:Or2n1e UTSW 17 38,585,932 (GRCm39) missense probably benign 0.39
R1748:Or2n1e UTSW 17 38,585,997 (GRCm39) missense possibly damaging 0.50
R1862:Or2n1e UTSW 17 38,586,235 (GRCm39) missense probably damaging 0.99
R2251:Or2n1e UTSW 17 38,585,794 (GRCm39) missense probably benign 0.01
R3436:Or2n1e UTSW 17 38,586,421 (GRCm39) missense probably damaging 1.00
R4731:Or2n1e UTSW 17 38,586,438 (GRCm39) missense probably damaging 1.00
R4732:Or2n1e UTSW 17 38,586,438 (GRCm39) missense probably damaging 1.00
R4733:Or2n1e UTSW 17 38,586,438 (GRCm39) missense probably damaging 1.00
R5404:Or2n1e UTSW 17 38,586,517 (GRCm39) nonsense probably null
R5443:Or2n1e UTSW 17 38,585,905 (GRCm39) missense probably damaging 0.99
R5683:Or2n1e UTSW 17 38,586,437 (GRCm39) missense possibly damaging 0.69
R6058:Or2n1e UTSW 17 38,586,150 (GRCm39) missense probably damaging 0.99
R6061:Or2n1e UTSW 17 38,585,772 (GRCm39) missense probably benign
R6266:Or2n1e UTSW 17 38,586,039 (GRCm39) missense probably benign 0.22
R7520:Or2n1e UTSW 17 38,586,331 (GRCm39) missense probably benign 0.00
R7717:Or2n1e UTSW 17 38,586,471 (GRCm39) missense probably damaging 1.00
R7959:Or2n1e UTSW 17 38,586,602 (GRCm39) makesense probably null
R8256:Or2n1e UTSW 17 38,586,411 (GRCm39) missense probably damaging 0.99
R9241:Or2n1e UTSW 17 38,585,781 (GRCm39) missense probably benign 0.00
R9509:Or2n1e UTSW 17 38,586,281 (GRCm39) missense probably benign 0.01
X0024:Or2n1e UTSW 17 38,586,336 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CATTGTGCCTCAGATGCTGTTTAACC -3'
(R):5'- GTCCCTTGTGATAGATGAAGAAGGCTG -3'

Sequencing Primer
(F):5'- TGTTTAACCTGGGAAGCTCC -3'
(R):5'- CTGAAGGTACATGCTAATACCTGGAC -3'
Posted On 2014-01-29