Incidental Mutation 'R1293:Wtip'
ID 150705
Institutional Source Beutler Lab
Gene Symbol Wtip
Ensembl Gene ENSMUSG00000036459
Gene Name WT1 interacting protein
Synonyms
MMRRC Submission 039359-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.570) question?
Stock # R1293 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 33808968-33832693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 33809646 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 359 (S359G)
Ref Sequence ENSEMBL: ENSMUSP00000047623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038537] [ENSMUST00000140911]
AlphaFold Q7TQJ8
Predicted Effect possibly damaging
Transcript: ENSMUST00000038537
AA Change: S359G

PolyPhen 2 Score 0.495 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000047623
Gene: ENSMUSG00000036459
AA Change: S359G

DomainStartEndE-ValueType
low complexity region 7 20 N/A INTRINSIC
low complexity region 48 57 N/A INTRINSIC
low complexity region 74 90 N/A INTRINSIC
low complexity region 98 124 N/A INTRINSIC
low complexity region 147 163 N/A INTRINSIC
low complexity region 165 187 N/A INTRINSIC
LIM 192 245 1.23e-14 SMART
LIM 257 309 9.09e-18 SMART
LIM 317 378 5.27e-14 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123813
Predicted Effect probably benign
Transcript: ENSMUST00000140911
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205914
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 G A 2: 155,393,141 (GRCm39) R289Q probably benign Het
Adgrl4 G A 3: 151,213,081 (GRCm39) E374K probably benign Het
Ate1 G A 7: 129,996,455 (GRCm39) R505C probably benign Het
Cntn4 T C 6: 106,330,685 (GRCm39) I101T probably benign Het
Dmtf1 T A 5: 9,190,383 (GRCm39) probably null Het
Dnah17 C A 11: 118,017,963 (GRCm39) probably null Het
Efhc1 A G 1: 21,048,996 (GRCm39) T470A probably damaging Het
Fam118b A T 9: 35,132,721 (GRCm39) Y313N probably damaging Het
Gm10142 T C 10: 77,551,869 (GRCm39) S77P probably benign Het
Kat8 T C 7: 127,521,422 (GRCm39) probably null Het
Lrp2 T C 2: 69,353,646 (GRCm39) probably null Het
Lrrc10 A G 10: 116,881,838 (GRCm39) T171A probably benign Het
Mcidas A G 13: 113,133,926 (GRCm39) T137A probably benign Het
Med1 G A 11: 98,047,862 (GRCm39) T978I possibly damaging Het
Muc6 C A 7: 141,238,255 (GRCm39) C75F probably damaging Het
Olfm3 A G 3: 114,895,579 (GRCm39) I154V possibly damaging Het
Or2ag15 A G 7: 106,341,058 (GRCm39) C28R probably damaging Het
Or2y12 G A 11: 49,426,393 (GRCm39) C127Y probably damaging Het
Or5ak22 T A 2: 85,230,697 (GRCm39) probably null Het
Or7g30 A T 9: 19,352,728 (GRCm39) E173V probably benign Het
Rsrc1 G A 3: 67,263,612 (GRCm39) R324Q probably damaging Het
Samd9l G T 6: 3,373,947 (GRCm39) P1105T possibly damaging Het
Sgcb C A 5: 73,792,870 (GRCm39) V311F probably benign Het
Siglec1 A G 2: 130,915,451 (GRCm39) V1380A probably benign Het
Spred1 C T 2: 117,007,889 (GRCm39) P265L probably damaging Het
Unc13b T A 4: 43,235,190 (GRCm39) H3259Q probably damaging Het
Unc13c C T 9: 73,481,356 (GRCm39) D1694N probably benign Het
Usp24 A G 4: 106,280,750 (GRCm39) R2355G probably benign Het
Vmn1r53 T A 6: 90,201,196 (GRCm39) N43Y possibly damaging Het
Zfp984 T A 4: 147,840,398 (GRCm39) K151M possibly damaging Het
Other mutations in Wtip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02502:Wtip APN 7 33,818,094 (GRCm39) splice site probably null
IGL03115:Wtip APN 7 33,824,958 (GRCm39) missense probably damaging 1.00
R1171:Wtip UTSW 7 33,824,921 (GRCm39) missense probably damaging 1.00
R1607:Wtip UTSW 7 33,816,020 (GRCm39) missense probably damaging 1.00
R1944:Wtip UTSW 7 33,818,363 (GRCm39) missense probably benign 0.16
R4902:Wtip UTSW 7 33,818,437 (GRCm39) splice site probably null
R7202:Wtip UTSW 7 33,832,087 (GRCm39) missense probably benign
R7687:Wtip UTSW 7 33,816,044 (GRCm39) missense probably damaging 1.00
R8743:Wtip UTSW 7 33,824,979 (GRCm39) missense possibly damaging 0.70
R8910:Wtip UTSW 7 33,832,063 (GRCm39) missense possibly damaging 0.65
R9255:Wtip UTSW 7 33,824,908 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CTACTGTGCGAGTGTCCTGGAATC -3'
(R):5'- CAATAGCTCATTAGGCTGAGCCCAC -3'

Sequencing Primer
(F):5'- AGTGTCCTGGAATCCAGCAG -3'
(R):5'- TTAGGCTGAGCCCACAGTTAC -3'
Posted On 2014-01-29