Incidental Mutation 'R0025:Zfp941'
| ID |
15130 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp941
|
| Ensembl Gene |
ENSMUSG00000060314 |
| Gene Name |
zinc finger protein 941 |
| Synonyms |
BC066028 |
| MMRRC Submission |
038320-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R0025 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
140387362-140402091 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 140393185 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 58
(D58G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079482
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080651]
[ENSMUST00000106052]
[ENSMUST00000150053]
[ENSMUST00000209690]
|
| AlphaFold |
Q3URY5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080651
AA Change: D58G
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
AA Change: D58G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106052
AA Change: D58G
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: D58G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
640 |
662 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150053
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209690
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 75.6%
- 3x: 62.5%
- 10x: 33.3%
- 20x: 15.9%
|
| Validation Efficiency |
95% (69/73) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm1 |
A |
T |
7: 119,257,538 (GRCm39) |
T435S |
probably damaging |
Het |
| Agtpbp1 |
G |
A |
13: 59,648,014 (GRCm39) |
T602I |
probably benign |
Het |
| Ahnak2 |
T |
A |
12: 112,749,154 (GRCm39) |
D231V |
probably damaging |
Het |
| Ampd3 |
G |
A |
7: 110,392,876 (GRCm39) |
D215N |
probably benign |
Het |
| Ate1 |
A |
G |
7: 130,105,523 (GRCm39) |
S332P |
probably damaging |
Het |
| Ces1f |
T |
C |
8: 93,998,513 (GRCm39) |
E161G |
probably benign |
Het |
| Ces2g |
A |
G |
8: 105,692,628 (GRCm39) |
|
probably benign |
Het |
| Cntnap4 |
T |
G |
8: 113,529,796 (GRCm39) |
L668R |
probably damaging |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Csf1 |
A |
G |
3: 107,655,960 (GRCm39) |
V245A |
probably benign |
Het |
| Ctss |
A |
G |
3: 95,457,448 (GRCm39) |
Y302C |
probably damaging |
Het |
| Dbt |
C |
T |
3: 116,328,432 (GRCm39) |
H158Y |
probably benign |
Het |
| Dennd6b |
T |
C |
15: 89,070,386 (GRCm39) |
I428V |
probably benign |
Het |
| Dnah9 |
G |
A |
11: 65,860,781 (GRCm39) |
|
probably benign |
Het |
| Dock3 |
G |
T |
9: 106,790,467 (GRCm39) |
Q1419K |
possibly damaging |
Het |
| Enpp6 |
A |
G |
8: 47,519,035 (GRCm39) |
K268E |
probably damaging |
Het |
| Eps15l1 |
T |
G |
8: 73,135,341 (GRCm39) |
|
probably benign |
Het |
| Gm10800 |
C |
A |
2: 98,496,925 (GRCm39) |
M209I |
probably benign |
Het |
| Herc3 |
C |
T |
6: 58,851,293 (GRCm39) |
P514L |
probably damaging |
Het |
| Mark2 |
T |
C |
19: 7,263,287 (GRCm39) |
D160G |
probably damaging |
Het |
| Mbd4 |
A |
G |
6: 115,821,529 (GRCm39) |
|
probably null |
Het |
| Mink1 |
T |
C |
11: 70,503,868 (GRCm39) |
W1263R |
probably damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,780,465 (GRCm39) |
|
probably benign |
Het |
| Osbp |
T |
C |
19: 11,961,322 (GRCm39) |
Y454H |
probably damaging |
Het |
| Pak5 |
T |
C |
2: 135,942,704 (GRCm39) |
K479E |
possibly damaging |
Het |
| Pard3 |
C |
A |
8: 127,888,058 (GRCm39) |
D73E |
probably damaging |
Het |
| Pmp22 |
A |
T |
11: 63,049,076 (GRCm39) |
|
probably null |
Het |
| Scn4a |
C |
T |
11: 106,215,386 (GRCm39) |
V1197I |
probably benign |
Het |
| Slc36a2 |
A |
G |
11: 55,053,621 (GRCm39) |
L339P |
probably damaging |
Het |
| Smg1 |
G |
A |
7: 117,811,666 (GRCm39) |
T104I |
possibly damaging |
Het |
| Stx18 |
T |
A |
5: 38,249,908 (GRCm39) |
Y74N |
probably damaging |
Het |
| Stxbp5 |
A |
T |
10: 9,638,492 (GRCm39) |
H1102Q |
probably damaging |
Het |
| Tom1l2 |
T |
C |
11: 60,120,960 (GRCm39) |
K450E |
probably damaging |
Het |
| Tpo |
T |
C |
12: 30,150,389 (GRCm39) |
Q497R |
probably benign |
Het |
| Tsc2 |
A |
G |
17: 24,849,978 (GRCm39) |
|
probably benign |
Het |
| Tut7 |
A |
T |
13: 59,953,142 (GRCm39) |
D99E |
probably benign |
Het |
| Vit |
G |
A |
17: 78,907,264 (GRCm39) |
G229R |
probably benign |
Het |
| Vwf |
T |
A |
6: 125,659,775 (GRCm39) |
I2658N |
probably benign |
Het |
| Wdr36 |
T |
A |
18: 32,992,360 (GRCm39) |
D632E |
probably damaging |
Het |
| Zfp654 |
A |
G |
16: 64,605,181 (GRCm39) |
V466A |
probably benign |
Het |
|
| Other mutations in Zfp941 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01393:Zfp941
|
APN |
7 |
140,391,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Zfp941
|
APN |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL03202:Zfp941
|
APN |
7 |
140,392,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0025:Zfp941
|
UTSW |
7 |
140,393,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0226:Zfp941
|
UTSW |
7 |
140,393,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0945:Zfp941
|
UTSW |
7 |
140,391,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1455:Zfp941
|
UTSW |
7 |
140,392,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1581:Zfp941
|
UTSW |
7 |
140,392,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2474:Zfp941
|
UTSW |
7 |
140,391,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4052:Zfp941
|
UTSW |
7 |
140,392,340 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Zfp941
|
UTSW |
7 |
140,391,503 (GRCm39) |
nonsense |
probably null |
|
|
R4604:Zfp941
|
UTSW |
7 |
140,392,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5170:Zfp941
|
UTSW |
7 |
140,392,870 (GRCm39) |
unclassified |
probably benign |
|
|
R5311:Zfp941
|
UTSW |
7 |
140,391,872 (GRCm39) |
nonsense |
probably null |
|
|
R5505:Zfp941
|
UTSW |
7 |
140,391,830 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5549:Zfp941
|
UTSW |
7 |
140,388,021 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5566:Zfp941
|
UTSW |
7 |
140,392,679 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5723:Zfp941
|
UTSW |
7 |
140,392,763 (GRCm39) |
unclassified |
probably benign |
|
|
R5736:Zfp941
|
UTSW |
7 |
140,392,973 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5861:Zfp941
|
UTSW |
7 |
140,392,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Zfp941
|
UTSW |
7 |
140,392,158 (GRCm39) |
nonsense |
probably null |
|
|
R6058:Zfp941
|
UTSW |
7 |
140,392,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Zfp941
|
UTSW |
7 |
140,392,398 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6488:Zfp941
|
UTSW |
7 |
140,392,663 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6824:Zfp941
|
UTSW |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7356:Zfp941
|
UTSW |
7 |
140,392,028 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7554:Zfp941
|
UTSW |
7 |
140,391,970 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zfp941
|
UTSW |
7 |
140,392,099 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
| Posted On |
2012-12-12 |
Incidental Mutation