Incidental Mutation 'R1259:Prl'
ID 151557
Institutional Source Beutler Lab
Gene Symbol Prl
Ensembl Gene ENSMUSG00000021342
Gene Name prolactin
Synonyms Prl1a1, Prl
MMRRC Submission 039326-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R1259 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27241553-27249187 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 27245472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153245 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018061] [ENSMUST00000018061] [ENSMUST00000110369] [ENSMUST00000110369] [ENSMUST00000224228] [ENSMUST00000224228]
AlphaFold P06879
Predicted Effect probably null
Transcript: ENSMUST00000018061
SMART Domains Protein: ENSMUSP00000018061
Gene: ENSMUSG00000021342

DomainStartEndE-ValueType
Pfam:Hormone_1 15 225 1.6e-61 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000018061
SMART Domains Protein: ENSMUSP00000018061
Gene: ENSMUSG00000021342

DomainStartEndE-ValueType
Pfam:Hormone_1 15 225 1.6e-61 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000110369
SMART Domains Protein: ENSMUSP00000105998
Gene: ENSMUSG00000021342

DomainStartEndE-ValueType
Pfam:Hormone_1 18 228 4.7e-59 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000110369
SMART Domains Protein: ENSMUSP00000105998
Gene: ENSMUSG00000021342

DomainStartEndE-ValueType
Pfam:Hormone_1 18 228 4.7e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223686
Predicted Effect probably null
Transcript: ENSMUST00000224228
Predicted Effect probably null
Transcript: ENSMUST00000224228
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224627
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a T A 8: 44,021,684 (GRCm39) D602V probably benign Het
Adam26a T C 8: 44,021,750 (GRCm39) D580G possibly damaging Het
B4galt6 T G 18: 20,839,559 (GRCm39) E125A possibly damaging Het
Dnm1l A G 16: 16,141,870 (GRCm39) I292T possibly damaging Het
Elp3 A T 14: 65,785,388 (GRCm39) I471K probably damaging Het
Fbxw13 A T 9: 109,014,439 (GRCm39) V83E probably damaging Het
Gm5422 T C 10: 31,125,111 (GRCm39) noncoding transcript Het
Krtap6-5 C T 16: 88,844,607 (GRCm39) R42H unknown Het
Lpcat2b C T 5: 107,581,763 (GRCm39) A364V probably damaging Het
Ltbp1 A G 17: 75,532,280 (GRCm39) Q118R possibly damaging Het
Lypd9 A G 11: 58,338,296 (GRCm39) I32T probably benign Het
Med7 C G 11: 46,331,460 (GRCm39) I18M probably damaging Het
Muc6 T A 7: 141,226,464 (GRCm39) probably benign Het
Or8b42 T A 9: 38,342,169 (GRCm39) L197Q probably damaging Het
Or8k16 T A 2: 85,519,875 (GRCm39) I34N probably damaging Het
Pbrm1 T C 14: 30,796,771 (GRCm39) F871L probably damaging Het
Pgbd5 T A 8: 125,097,324 (GRCm39) D493V probably damaging Het
Pik3cd G A 4: 149,735,105 (GRCm39) R1046* probably null Het
Pom121l2 G A 13: 22,166,297 (GRCm39) W189* probably null Het
Prex2 C A 1: 11,359,494 (GRCm39) N1567K probably damaging Het
Ptpro T C 6: 137,369,739 (GRCm39) V517A probably damaging Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Tenm2 C T 11: 35,954,004 (GRCm39) G1236R possibly damaging Het
Vmn2r12 T A 5: 109,239,763 (GRCm39) I267F probably damaging Het
Wasf3 T C 5: 146,388,786 (GRCm39) V80A probably damaging Het
Other mutations in Prl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01081:Prl APN 13 27,249,024 (GRCm39) missense possibly damaging 0.93
IGL02514:Prl APN 13 27,243,377 (GRCm39) missense probably damaging 1.00
IGL02638:Prl APN 13 27,245,562 (GRCm39) missense probably benign 0.02
IGL03093:Prl APN 13 27,248,870 (GRCm39) missense probably benign 0.04
R0479:Prl UTSW 13 27,248,911 (GRCm39) missense probably damaging 1.00
R1489:Prl UTSW 13 27,241,619 (GRCm39) missense probably damaging 0.96
R4392:Prl UTSW 13 27,248,334 (GRCm39) missense possibly damaging 0.83
R5183:Prl UTSW 13 27,241,579 (GRCm39) start gained probably benign
R6623:Prl UTSW 13 27,245,492 (GRCm39) missense probably benign 0.01
R6831:Prl UTSW 13 27,243,530 (GRCm39) missense probably benign 0.01
R6860:Prl UTSW 13 27,248,942 (GRCm39) missense possibly damaging 0.89
R8806:Prl UTSW 13 27,243,515 (GRCm39) missense probably damaging 0.98
R9254:Prl UTSW 13 27,243,503 (GRCm39) missense probably damaging 1.00
R9379:Prl UTSW 13 27,243,503 (GRCm39) missense probably damaging 1.00
R9744:Prl UTSW 13 27,248,338 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- AGTCACAATCCACGTCCTTATATTCAGC -3'
(R):5'- CAGTGCTCTGATAACCTGGAATACACC -3'

Sequencing Primer
(F):5'- GTCCTGTGCAAGTTCATAGATTCAG -3'
(R):5'- CTGGAATACACCAAAACCAGTG -3'
Posted On 2014-01-29