Incidental Mutation 'R1240:Vmn2r25'
ID 151935
Institutional Source Beutler Lab
Gene Symbol Vmn2r25
Ensembl Gene ENSMUSG00000094672
Gene Name vomeronasal 2, receptor 25
Synonyms EG545874
MMRRC Submission 039307-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R1240 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 123799773-123830149 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 123828864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 137 (S137C)
Ref Sequence ENSEMBL: ENSMUSP00000124342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162046]
AlphaFold W4VSP2
Predicted Effect probably damaging
Transcript: ENSMUST00000162046
AA Change: S137C

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: S137C

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 473 6e-31 PFAM
Pfam:NCD3G 519 572 5.8e-25 PFAM
Pfam:7tm_3 603 840 4.8e-55 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb9 T G 5: 124,227,984 (GRCm39) I86L probably benign Het
Ankfn1 A G 11: 89,282,960 (GRCm39) L229P probably damaging Het
Aoc1 T C 6: 48,882,549 (GRCm39) S164P probably benign Het
Arhgef28 C T 13: 98,066,000 (GRCm39) V1618I probably benign Het
Arpc3 T C 5: 122,542,242 (GRCm39) F88S probably damaging Het
Asgr2 G T 11: 69,987,676 (GRCm39) R58L possibly damaging Het
Bach2 T C 4: 32,563,198 (GRCm39) F432S probably damaging Het
Brms1l C A 12: 55,891,293 (GRCm39) R116S probably damaging Het
Casp2 T A 6: 42,245,879 (GRCm39) C179S probably damaging Het
Ccdc73 A T 2: 104,821,906 (GRCm39) E618D probably benign Het
Cdh6 T A 15: 13,057,541 (GRCm39) D260V possibly damaging Het
Cenpc1 G T 5: 86,183,369 (GRCm39) N473K probably benign Het
Chst2 T C 9: 95,287,536 (GRCm39) E270G possibly damaging Het
Chst9 C T 18: 15,586,231 (GRCm39) E111K probably benign Het
Cyp3a44 T G 5: 145,711,250 (GRCm39) I474L probably benign Het
Dbr1 G T 9: 99,466,073 (GRCm39) E550D probably benign Het
Dph6 T C 2: 114,475,199 (GRCm39) probably null Het
Fam227b T A 2: 125,966,505 (GRCm39) I136L possibly damaging Het
Fcgbp A G 7: 27,819,950 (GRCm39) N2559S probably damaging Het
Fh1 A T 1: 175,431,581 (GRCm39) I435N probably damaging Het
Gab1 A C 8: 81,515,159 (GRCm39) S386R probably damaging Het
Gkn1 T A 6: 87,326,098 (GRCm39) N31Y probably damaging Het
Grk2 A G 19: 4,340,707 (GRCm39) C251R probably damaging Het
H2-DMa G T 17: 34,357,380 (GRCm39) probably null Het
Hp1bp3 T C 4: 137,957,009 (GRCm39) S63P probably damaging Het
Ift74 A G 4: 94,581,174 (GRCm39) probably null Het
Inf2 G A 12: 112,577,210 (GRCm39) R1018Q unknown Het
Kat2b A G 17: 53,931,425 (GRCm39) D141G probably benign Het
Klhl30 T C 1: 91,288,737 (GRCm39) S499P probably benign Het
Lama2 A C 10: 26,917,120 (GRCm39) D2268E probably damaging Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Marf1 T C 16: 13,964,626 (GRCm39) N258S possibly damaging Het
Mc1r T A 8: 124,134,999 (GRCm39) C251S probably damaging Het
Myo15b C A 11: 115,771,327 (GRCm39) Q257K possibly damaging Het
Nbeal2 A G 9: 110,456,176 (GRCm39) F2431S probably damaging Het
Neb T A 2: 52,186,321 (GRCm39) H917L possibly damaging Het
Nlrp1a A G 11: 71,004,292 (GRCm39) probably null Het
Nr1d2 A T 14: 18,211,891 (GRCm38) M404K probably benign Het
Or4b1d T G 2: 89,969,157 (GRCm39) I109L possibly damaging Het
Or8u8 T G 2: 86,012,453 (GRCm39) M1L possibly damaging Het
Otoa T C 7: 120,755,713 (GRCm39) S1040P probably benign Het
Pctp T C 11: 89,893,640 (GRCm39) D10G probably benign Het
Pja2 G T 17: 64,616,613 (GRCm39) T94K probably benign Het
Plxna1 C T 6: 89,298,032 (GRCm39) V1749M probably damaging Het
Prdm15 C T 16: 97,638,800 (GRCm39) E87K probably damaging Het
Rgsl1 A G 1: 153,660,937 (GRCm39) F1028L probably benign Het
Sepsecs T C 5: 52,818,021 (GRCm39) N252S probably damaging Het
Skint5 A T 4: 113,574,304 (GRCm39) L749Q unknown Het
Slc22a22 G A 15: 57,114,268 (GRCm39) S353F probably benign Het
Slc49a4 A G 16: 35,518,379 (GRCm39) F445L probably benign Het
Slc7a13 A T 4: 19,819,212 (GRCm39) K137N probably damaging Het
Snx13 G T 12: 35,141,405 (GRCm39) V163L probably damaging Het
Synrg A T 11: 83,914,182 (GRCm39) T1115S probably damaging Het
Tenm3 A G 8: 48,740,928 (GRCm39) V1185A possibly damaging Het
Tent5b T C 4: 133,213,815 (GRCm39) F229L probably benign Het
Tg T A 15: 66,700,397 (GRCm39) N118K probably benign Het
Top1mt T C 15: 75,541,916 (GRCm39) K153E probably damaging Het
Trmt11 T C 10: 30,466,821 (GRCm39) probably benign Het
Unc80 A G 1: 66,675,061 (GRCm39) D1953G possibly damaging Het
Vwf C A 6: 125,580,271 (GRCm39) probably null Het
Other mutations in Vmn2r25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Vmn2r25 APN 6 123,830,130 (GRCm39) missense probably benign 0.25
IGL01781:Vmn2r25 APN 6 123,816,324 (GRCm39) missense possibly damaging 0.48
IGL01843:Vmn2r25 APN 6 123,829,962 (GRCm39) missense possibly damaging 0.67
IGL02023:Vmn2r25 APN 6 123,816,388 (GRCm39) missense probably damaging 0.96
IGL02502:Vmn2r25 APN 6 123,816,392 (GRCm39) missense probably damaging 0.96
IGL02709:Vmn2r25 APN 6 123,816,723 (GRCm39) missense possibly damaging 0.50
IGL03053:Vmn2r25 APN 6 123,800,077 (GRCm39) missense probably damaging 1.00
PIT4468001:Vmn2r25 UTSW 6 123,816,557 (GRCm39) missense probably benign 0.00
PIT4812001:Vmn2r25 UTSW 6 123,800,447 (GRCm39) missense probably damaging 1.00
R0054:Vmn2r25 UTSW 6 123,829,984 (GRCm39) missense probably benign 0.00
R0312:Vmn2r25 UTSW 6 123,805,539 (GRCm39) splice site probably benign
R0366:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R0390:Vmn2r25 UTSW 6 123,800,140 (GRCm39) missense probably damaging 1.00
R0466:Vmn2r25 UTSW 6 123,829,008 (GRCm39) missense probably benign 0.16
R0541:Vmn2r25 UTSW 6 123,816,786 (GRCm39) missense probably damaging 0.97
R0612:Vmn2r25 UTSW 6 123,816,481 (GRCm39) missense probably damaging 1.00
R0865:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R1219:Vmn2r25 UTSW 6 123,816,282 (GRCm39) missense probably benign 0.00
R1701:Vmn2r25 UTSW 6 123,828,754 (GRCm39) splice site probably null
R1780:Vmn2r25 UTSW 6 123,805,424 (GRCm39) missense probably damaging 1.00
R1809:Vmn2r25 UTSW 6 123,802,337 (GRCm39) missense probably benign 0.00
R1833:Vmn2r25 UTSW 6 123,816,643 (GRCm39) missense probably benign 0.01
R1964:Vmn2r25 UTSW 6 123,800,254 (GRCm39) missense possibly damaging 0.94
R2154:Vmn2r25 UTSW 6 123,816,805 (GRCm39) missense probably benign 0.01
R2164:Vmn2r25 UTSW 6 123,816,518 (GRCm39) missense possibly damaging 0.96
R3799:Vmn2r25 UTSW 6 123,830,143 (GRCm39) missense probably benign 0.12
R3836:Vmn2r25 UTSW 6 123,830,044 (GRCm39) missense probably damaging 1.00
R3946:Vmn2r25 UTSW 6 123,817,057 (GRCm39) missense probably damaging 0.97
R4282:Vmn2r25 UTSW 6 123,800,606 (GRCm39) missense probably damaging 1.00
R4367:Vmn2r25 UTSW 6 123,805,496 (GRCm39) missense probably damaging 1.00
R4438:Vmn2r25 UTSW 6 123,816,756 (GRCm39) missense probably benign 0.03
R4488:Vmn2r25 UTSW 6 123,799,819 (GRCm39) missense probably damaging 1.00
R4580:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.46
R4631:Vmn2r25 UTSW 6 123,829,962 (GRCm39) missense possibly damaging 0.94
R4765:Vmn2r25 UTSW 6 123,800,182 (GRCm39) missense probably damaging 1.00
R4908:Vmn2r25 UTSW 6 123,805,406 (GRCm39) missense probably benign
R5207:Vmn2r25 UTSW 6 123,817,062 (GRCm39) missense probably damaging 1.00
R5254:Vmn2r25 UTSW 6 123,802,277 (GRCm39) missense probably damaging 1.00
R5444:Vmn2r25 UTSW 6 123,805,451 (GRCm39) missense probably benign 0.00
R5586:Vmn2r25 UTSW 6 123,802,255 (GRCm39) missense probably damaging 1.00
R5607:Vmn2r25 UTSW 6 123,805,318 (GRCm39) missense possibly damaging 0.49
R5985:Vmn2r25 UTSW 6 123,800,587 (GRCm39) missense probably benign
R6046:Vmn2r25 UTSW 6 123,799,876 (GRCm39) missense probably damaging 1.00
R6057:Vmn2r25 UTSW 6 123,799,900 (GRCm39) missense possibly damaging 0.69
R6569:Vmn2r25 UTSW 6 123,828,941 (GRCm39) missense probably benign 0.01
R6826:Vmn2r25 UTSW 6 123,800,071 (GRCm39) missense probably damaging 1.00
R7054:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R7120:Vmn2r25 UTSW 6 123,805,394 (GRCm39) missense possibly damaging 0.51
R7177:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7287:Vmn2r25 UTSW 6 123,829,040 (GRCm39) missense possibly damaging 0.49
R7397:Vmn2r25 UTSW 6 123,800,498 (GRCm39) missense probably damaging 0.96
R7486:Vmn2r25 UTSW 6 123,800,101 (GRCm39) missense probably damaging 1.00
R7699:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7700:Vmn2r25 UTSW 6 123,816,882 (GRCm39) missense possibly damaging 0.94
R7759:Vmn2r25 UTSW 6 123,800,339 (GRCm39) missense probably damaging 0.99
R7802:Vmn2r25 UTSW 6 123,828,791 (GRCm39) missense possibly damaging 0.88
R7850:Vmn2r25 UTSW 6 123,805,431 (GRCm39) missense probably damaging 1.00
R8064:Vmn2r25 UTSW 6 123,800,581 (GRCm39) nonsense probably null
R8170:Vmn2r25 UTSW 6 123,829,976 (GRCm39) missense probably benign 0.09
R8340:Vmn2r25 UTSW 6 123,829,972 (GRCm39) missense probably benign 0.01
R8346:Vmn2r25 UTSW 6 123,802,350 (GRCm39) missense probably benign 0.00
R8395:Vmn2r25 UTSW 6 123,799,982 (GRCm39) missense possibly damaging 0.81
R8889:Vmn2r25 UTSW 6 123,800,569 (GRCm39) missense probably damaging 1.00
R9094:Vmn2r25 UTSW 6 123,805,391 (GRCm39) missense probably benign 0.44
R9204:Vmn2r25 UTSW 6 123,830,092 (GRCm39) missense probably benign 0.00
R9253:Vmn2r25 UTSW 6 123,816,960 (GRCm39) missense probably damaging 0.98
R9392:Vmn2r25 UTSW 6 123,816,937 (GRCm39) missense probably benign
R9520:Vmn2r25 UTSW 6 123,830,066 (GRCm39) nonsense probably null
R9525:Vmn2r25 UTSW 6 123,800,164 (GRCm39) missense probably damaging 1.00
R9622:Vmn2r25 UTSW 6 123,816,579 (GRCm39) missense probably damaging 0.99
X0020:Vmn2r25 UTSW 6 123,816,359 (GRCm39) missense possibly damaging 0.95
Z1176:Vmn2r25 UTSW 6 123,799,856 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-01-29