Incidental Mutation 'R1244:Vmn1r77'
| ID |
152083 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r77
|
| Ensembl Gene |
ENSMUSG00000095864 |
| Gene Name |
vomeronasal 1 receptor 77 |
| Synonyms |
Gm6935 |
| MMRRC Submission |
039311-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R1244 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
11775226-11776146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 11775847 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 140
(T140S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154253
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164446]
[ENSMUST00000226525]
[ENSMUST00000227320]
[ENSMUST00000228213]
|
| AlphaFold |
E9PY60 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164446
AA Change: T208S
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000130869
Gene: ENSMUSG00000095864
AA Change: T208S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
300 |
1.9e-12 |
PFAM |
|
Pfam:V1R
|
35 |
299 |
5.3e-26 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226525
AA Change: T140S
PolyPhen 2
Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227320
AA Change: T208S
PolyPhen 2
Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228213
AA Change: T140S
PolyPhen 2
Score 0.593 (Sensitivity: 0.87; Specificity: 0.91)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
C |
T |
12: 71,262,918 (GRCm39) |
T1417I |
probably benign |
Het |
| Abca14 |
G |
A |
7: 119,815,561 (GRCm39) |
A270T |
probably benign |
Het |
| Abtb3 |
C |
A |
10: 85,223,227 (GRCm39) |
T12K |
unknown |
Het |
| Ash2l |
T |
C |
8: 26,307,449 (GRCm39) |
S529G |
probably damaging |
Het |
| Atp13a3 |
T |
C |
16: 30,180,654 (GRCm39) |
Y125C |
probably benign |
Het |
| Calca |
A |
G |
7: 114,232,962 (GRCm39) |
Y96H |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 22,946,417 (GRCm39) |
E131G |
probably benign |
Het |
| Cd84 |
A |
G |
1: 171,679,397 (GRCm39) |
D25G |
probably damaging |
Het |
| Chd9 |
A |
G |
8: 91,749,557 (GRCm39) |
D1728G |
probably damaging |
Het |
| Cyp39a1 |
A |
T |
17: 44,060,836 (GRCm39) |
K461N |
probably benign |
Het |
| Ddx50 |
T |
A |
10: 62,478,703 (GRCm39) |
Q161L |
probably damaging |
Het |
| Golga5 |
A |
G |
12: 102,438,554 (GRCm39) |
T90A |
probably benign |
Het |
| Heatr3 |
A |
G |
8: 88,868,367 (GRCm39) |
E39G |
possibly damaging |
Het |
| Hipk3 |
G |
A |
2: 104,263,601 (GRCm39) |
R905W |
probably damaging |
Het |
| Hsd11b1 |
T |
G |
1: 192,906,068 (GRCm39) |
M175L |
probably benign |
Het |
| Htra1 |
G |
A |
7: 130,586,799 (GRCm39) |
V461I |
possibly damaging |
Het |
| Il10 |
A |
G |
1: 130,951,953 (GRCm39) |
D162G |
probably damaging |
Het |
| Mapre2 |
A |
G |
18: 23,986,774 (GRCm39) |
K62R |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Ogfod1 |
A |
G |
8: 94,763,999 (GRCm39) |
D28G |
probably benign |
Het |
| Or5an10 |
A |
T |
19: 12,275,860 (GRCm39) |
I212N |
probably damaging |
Het |
| Perm1 |
C |
T |
4: 156,302,340 (GRCm39) |
R295C |
probably benign |
Het |
| Ppp4c |
A |
G |
7: 126,385,452 (GRCm39) |
V119A |
probably damaging |
Het |
| Scn2a |
T |
C |
2: 65,593,999 (GRCm39) |
I1616T |
probably damaging |
Het |
| Sipa1l1 |
A |
G |
12: 82,472,190 (GRCm39) |
N1390S |
probably benign |
Het |
| Sub1 |
A |
T |
15: 11,991,130 (GRCm39) |
V37E |
possibly damaging |
Het |
| Tbc1d17 |
A |
T |
7: 44,493,822 (GRCm39) |
V267E |
probably damaging |
Het |
| Ulk1 |
C |
T |
5: 110,937,223 (GRCm39) |
R691Q |
probably benign |
Het |
| Vmn2r15 |
A |
T |
5: 109,441,092 (GRCm39) |
Y255* |
probably null |
Het |
|
| Other mutations in Vmn1r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,403 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01304:Vmn1r77
|
APN |
7 |
11,775,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01360:Vmn1r77
|
APN |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01714:Vmn1r77
|
APN |
7 |
11,775,277 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01829:Vmn1r77
|
APN |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02336:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0456:Vmn1r77
|
UTSW |
7 |
11,775,665 (GRCm39) |
nonsense |
probably null |
|
|
R0622:Vmn1r77
|
UTSW |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1696:Vmn1r77
|
UTSW |
7 |
11,775,547 (GRCm39) |
nonsense |
probably null |
|
|
R1836:Vmn1r77
|
UTSW |
7 |
11,775,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1898:Vmn1r77
|
UTSW |
7 |
11,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4533:Vmn1r77
|
UTSW |
7 |
11,775,756 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4668:Vmn1r77
|
UTSW |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5381:Vmn1r77
|
UTSW |
7 |
11,775,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Vmn1r77
|
UTSW |
7 |
11,775,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Vmn1r77
|
UTSW |
7 |
11,775,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7032:Vmn1r77
|
UTSW |
7 |
11,776,017 (GRCm39) |
nonsense |
probably null |
|
|
R7044:Vmn1r77
|
UTSW |
7 |
11,775,761 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7302:Vmn1r77
|
UTSW |
7 |
11,775,983 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7417:Vmn1r77
|
UTSW |
7 |
11,775,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7436:Vmn1r77
|
UTSW |
7 |
11,775,694 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8487:Vmn1r77
|
UTSW |
7 |
11,775,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8862:Vmn1r77
|
UTSW |
7 |
11,776,060 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9614:Vmn1r77
|
UTSW |
7 |
11,775,766 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9753:Vmn1r77
|
UTSW |
7 |
11,775,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,508 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGCAACTTCAAGTGGATGAAGC -3'
(R):5'- TTGGAACAGGTCCTAATGACAGCAAC -3'
Sequencing Primer
(F):5'- TGATTCCAGTAAGAGTGTCAGGC -3'
(R):5'- TCCTAATGACAGCAACAAGGGAAG -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation