Incidental Mutation 'R1230:Zfp62'
ID 152272
Institutional Source Beutler Lab
Gene Symbol Zfp62
Ensembl Gene ENSMUSG00000046311
Gene Name zinc finger protein 62
Synonyms
MMRRC Submission 039299-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R1230 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49094119-49109643 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49105926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 6 (S6P)
Ref Sequence ENSEMBL: ENSMUSP00000114147 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061757] [ENSMUST00000109197] [ENSMUST00000109198] [ENSMUST00000133150] [ENSMUST00000136539] [ENSMUST00000136691] [ENSMUST00000150284] [ENSMUST00000180016] [ENSMUST00000137061] [ENSMUST00000151228]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000061757
AA Change: S6P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000056226
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
ZnF_C2H2 180 202 2.75e-3 SMART
ZnF_C2H2 208 230 2.71e-2 SMART
ZnF_C2H2 236 258 7.37e-4 SMART
ZnF_C2H2 264 286 2.27e-4 SMART
ZnF_C2H2 292 314 4.11e-2 SMART
ZnF_C2H2 320 342 1.03e-2 SMART
ZnF_C2H2 348 370 4.54e-4 SMART
ZnF_C2H2 376 398 4.47e-3 SMART
ZnF_C2H2 404 426 4.4e-2 SMART
ZnF_C2H2 432 454 2.43e-4 SMART
ZnF_C2H2 460 482 1.38e-3 SMART
ZnF_C2H2 488 510 2.79e-4 SMART
ZnF_C2H2 516 538 5.9e-3 SMART
ZnF_C2H2 544 566 3.39e-3 SMART
ZnF_C2H2 572 594 3.89e-3 SMART
ZnF_C2H2 600 622 5.5e-3 SMART
ZnF_C2H2 628 650 2.75e-3 SMART
ZnF_C2H2 656 678 3.63e-3 SMART
ZnF_C2H2 684 706 7.9e-4 SMART
ZnF_C2H2 712 734 8.34e-3 SMART
ZnF_C2H2 740 762 1.98e-4 SMART
ZnF_C2H2 768 790 1.53e-1 SMART
ZnF_C2H2 796 817 1.16e1 SMART
ZnF_C2H2 823 845 5.99e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000109197
AA Change: S6P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104820
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
ZnF_C2H2 180 202 2.75e-3 SMART
ZnF_C2H2 208 230 2.71e-2 SMART
ZnF_C2H2 236 258 7.37e-4 SMART
ZnF_C2H2 264 286 2.27e-4 SMART
ZnF_C2H2 292 314 4.11e-2 SMART
ZnF_C2H2 320 342 1.03e-2 SMART
ZnF_C2H2 348 370 4.54e-4 SMART
ZnF_C2H2 376 398 4.47e-3 SMART
ZnF_C2H2 404 426 4.4e-2 SMART
ZnF_C2H2 432 454 2.43e-4 SMART
ZnF_C2H2 460 482 1.38e-3 SMART
ZnF_C2H2 488 510 2.79e-4 SMART
ZnF_C2H2 516 538 5.9e-3 SMART
ZnF_C2H2 544 566 3.39e-3 SMART
ZnF_C2H2 572 594 3.89e-3 SMART
ZnF_C2H2 600 622 5.5e-3 SMART
ZnF_C2H2 628 650 2.75e-3 SMART
ZnF_C2H2 656 678 3.63e-3 SMART
ZnF_C2H2 684 706 7.9e-4 SMART
ZnF_C2H2 712 734 8.34e-3 SMART
ZnF_C2H2 740 762 1.98e-4 SMART
ZnF_C2H2 768 790 1.53e-1 SMART
ZnF_C2H2 796 817 1.16e1 SMART
ZnF_C2H2 823 845 5.99e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000109198
AA Change: S6P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000104821
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
ZnF_C2H2 180 202 2.75e-3 SMART
ZnF_C2H2 208 230 2.71e-2 SMART
ZnF_C2H2 236 258 7.37e-4 SMART
ZnF_C2H2 264 286 2.27e-4 SMART
ZnF_C2H2 292 314 4.11e-2 SMART
ZnF_C2H2 320 342 1.03e-2 SMART
ZnF_C2H2 348 370 4.54e-4 SMART
ZnF_C2H2 376 398 4.47e-3 SMART
ZnF_C2H2 404 426 4.4e-2 SMART
ZnF_C2H2 432 454 2.43e-4 SMART
ZnF_C2H2 460 482 1.38e-3 SMART
ZnF_C2H2 488 510 2.79e-4 SMART
ZnF_C2H2 516 538 5.9e-3 SMART
ZnF_C2H2 544 566 3.39e-3 SMART
ZnF_C2H2 572 594 3.89e-3 SMART
ZnF_C2H2 600 622 5.5e-3 SMART
ZnF_C2H2 628 650 2.75e-3 SMART
ZnF_C2H2 656 678 3.63e-3 SMART
ZnF_C2H2 684 706 7.9e-4 SMART
ZnF_C2H2 712 734 8.34e-3 SMART
ZnF_C2H2 740 762 1.98e-4 SMART
ZnF_C2H2 768 790 1.53e-1 SMART
ZnF_C2H2 796 817 1.16e1 SMART
ZnF_C2H2 823 845 5.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128932
Predicted Effect possibly damaging
Transcript: ENSMUST00000133150
AA Change: S6P

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000136539
AA Change: S6P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000116045
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
ZnF_C2H2 180 202 2.75e-3 SMART
ZnF_C2H2 208 230 2.71e-2 SMART
ZnF_C2H2 236 258 7.37e-4 SMART
ZnF_C2H2 264 286 2.27e-4 SMART
ZnF_C2H2 292 314 4.11e-2 SMART
ZnF_C2H2 320 342 1.03e-2 SMART
ZnF_C2H2 348 370 4.54e-4 SMART
ZnF_C2H2 376 398 4.47e-3 SMART
ZnF_C2H2 404 426 4.4e-2 SMART
ZnF_C2H2 432 454 2.43e-4 SMART
ZnF_C2H2 460 482 1.38e-3 SMART
ZnF_C2H2 488 510 2.79e-4 SMART
ZnF_C2H2 516 538 5.9e-3 SMART
ZnF_C2H2 544 566 3.39e-3 SMART
ZnF_C2H2 572 594 3.89e-3 SMART
ZnF_C2H2 600 622 5.5e-3 SMART
ZnF_C2H2 628 650 2.75e-3 SMART
ZnF_C2H2 656 678 3.63e-3 SMART
ZnF_C2H2 684 706 7.9e-4 SMART
ZnF_C2H2 712 734 8.34e-3 SMART
ZnF_C2H2 740 762 1.98e-4 SMART
ZnF_C2H2 768 790 1.53e-1 SMART
ZnF_C2H2 796 817 1.16e1 SMART
ZnF_C2H2 823 845 5.99e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000136691
AA Change: S6P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect unknown
Transcript: ENSMUST00000150284
AA Change: S6P
Predicted Effect possibly damaging
Transcript: ENSMUST00000180016
AA Change: S6P

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000137583
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
ZnF_C2H2 180 202 2.75e-3 SMART
ZnF_C2H2 208 230 2.71e-2 SMART
ZnF_C2H2 236 258 7.37e-4 SMART
ZnF_C2H2 264 286 2.27e-4 SMART
ZnF_C2H2 292 314 4.11e-2 SMART
ZnF_C2H2 320 342 1.03e-2 SMART
ZnF_C2H2 348 370 4.54e-4 SMART
ZnF_C2H2 376 398 4.47e-3 SMART
ZnF_C2H2 404 426 4.4e-2 SMART
ZnF_C2H2 432 454 2.43e-4 SMART
ZnF_C2H2 460 482 1.38e-3 SMART
ZnF_C2H2 488 510 2.79e-4 SMART
ZnF_C2H2 516 538 5.9e-3 SMART
ZnF_C2H2 544 566 3.39e-3 SMART
ZnF_C2H2 572 594 3.89e-3 SMART
ZnF_C2H2 600 622 5.5e-3 SMART
ZnF_C2H2 628 650 2.75e-3 SMART
ZnF_C2H2 656 678 3.63e-3 SMART
ZnF_C2H2 684 706 7.9e-4 SMART
ZnF_C2H2 712 734 8.34e-3 SMART
ZnF_C2H2 740 762 1.98e-4 SMART
ZnF_C2H2 768 790 1.53e-1 SMART
ZnF_C2H2 796 817 1.16e1 SMART
ZnF_C2H2 823 845 5.99e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000137061
AA Change: S6P

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000151228
AA Change: S6P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000117774
Gene: ENSMUSG00000046311
AA Change: S6P

DomainStartEndE-ValueType
ZnF_C2H2 124 146 7.26e-3 SMART
ZnF_C2H2 152 174 7.26e-3 SMART
Pfam:zf-C2H2_6 179 195 2.3e-3 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157023
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.7%
  • 20x: 90.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc88c A T 12: 100,914,747 (GRCm39) Y496N probably benign Het
Cyp11b1 A G 15: 74,712,791 (GRCm39) I90T probably benign Het
Cyp4f14 C A 17: 33,135,762 (GRCm39) R33L probably benign Het
Dcc G A 18: 71,815,384 (GRCm39) P330L probably damaging Het
Dnm1 T C 2: 32,205,921 (GRCm39) N64D probably damaging Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Ecm1 A T 3: 95,642,738 (GRCm39) probably null Het
Enam A G 5: 88,641,927 (GRCm39) Y247C probably damaging Het
Ess2 C T 16: 17,727,814 (GRCm39) V122M probably benign Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hrc A G 7: 44,985,887 (GRCm39) D346G possibly damaging Het
Kdm5b T G 1: 134,540,992 (GRCm39) C695G probably damaging Het
Lrig3 A G 10: 125,838,840 (GRCm39) D449G probably damaging Het
Mrps31 C T 8: 22,909,759 (GRCm39) P142S possibly damaging Het
Ppm1k T C 6: 57,502,059 (GRCm39) T35A probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Vangl1 T A 3: 102,065,609 (GRCm39) I509L probably benign Het
Vcpip1 A G 1: 9,795,449 (GRCm39) V974A probably damaging Het
Xdh T C 17: 74,198,251 (GRCm39) E1212G probably damaging Het
Other mutations in Zfp62
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03342:Zfp62 APN 11 49,106,298 (GRCm39) nonsense probably null
R0416:Zfp62 UTSW 11 49,106,503 (GRCm39) missense probably damaging 1.00
R0540:Zfp62 UTSW 11 49,106,227 (GRCm39) missense probably benign
R0607:Zfp62 UTSW 11 49,106,227 (GRCm39) missense probably benign
R1119:Zfp62 UTSW 11 49,107,517 (GRCm39) missense probably damaging 0.99
R1644:Zfp62 UTSW 11 49,106,596 (GRCm39) missense probably damaging 0.99
R1710:Zfp62 UTSW 11 49,108,510 (GRCm39) missense probably benign
R1840:Zfp62 UTSW 11 49,107,215 (GRCm39) missense probably damaging 1.00
R1908:Zfp62 UTSW 11 49,107,047 (GRCm39) missense probably damaging 0.99
R3878:Zfp62 UTSW 11 49,105,960 (GRCm39) missense probably damaging 0.99
R4571:Zfp62 UTSW 11 49,106,569 (GRCm39) missense probably damaging 1.00
R4571:Zfp62 UTSW 11 49,106,568 (GRCm39) missense probably damaging 1.00
R4580:Zfp62 UTSW 11 49,107,099 (GRCm39) missense possibly damaging 0.91
R4631:Zfp62 UTSW 11 49,108,632 (GRCm39) makesense probably null
R5022:Zfp62 UTSW 11 49,106,556 (GRCm39) missense probably damaging 0.96
R5023:Zfp62 UTSW 11 49,106,556 (GRCm39) missense probably damaging 0.96
R5289:Zfp62 UTSW 11 49,107,975 (GRCm39) missense probably damaging 0.98
R5362:Zfp62 UTSW 11 49,107,439 (GRCm39) missense probably damaging 1.00
R5685:Zfp62 UTSW 11 49,107,044 (GRCm39) nonsense probably null
R6420:Zfp62 UTSW 11 49,107,340 (GRCm39) missense probably damaging 1.00
R6764:Zfp62 UTSW 11 49,105,996 (GRCm39) missense probably damaging 0.99
R7000:Zfp62 UTSW 11 49,107,206 (GRCm39) nonsense probably null
R7016:Zfp62 UTSW 11 49,106,764 (GRCm39) missense probably damaging 0.98
R7175:Zfp62 UTSW 11 49,107,580 (GRCm39) missense probably damaging 0.99
R7670:Zfp62 UTSW 11 49,105,903 (GRCm39) start gained probably benign
R7675:Zfp62 UTSW 11 49,106,847 (GRCm39) missense possibly damaging 0.75
R7686:Zfp62 UTSW 11 49,107,985 (GRCm39) missense probably damaging 1.00
R7801:Zfp62 UTSW 11 49,108,155 (GRCm39) missense possibly damaging 0.88
R8190:Zfp62 UTSW 11 49,106,902 (GRCm39) missense probably damaging 1.00
R8390:Zfp62 UTSW 11 49,106,019 (GRCm39) missense probably benign 0.02
R8401:Zfp62 UTSW 11 49,108,218 (GRCm39) missense probably damaging 1.00
R8479:Zfp62 UTSW 11 49,107,319 (GRCm39) missense probably damaging 0.98
R8735:Zfp62 UTSW 11 49,108,227 (GRCm39) missense probably damaging 1.00
R8809:Zfp62 UTSW 11 49,107,238 (GRCm39) missense probably damaging 0.98
R8972:Zfp62 UTSW 11 49,106,892 (GRCm39) missense possibly damaging 0.66
R9220:Zfp62 UTSW 11 49,106,075 (GRCm39) missense probably benign 0.17
R9261:Zfp62 UTSW 11 49,108,350 (GRCm39) missense probably benign 0.20
R9484:Zfp62 UTSW 11 49,108,108 (GRCm39) missense probably damaging 0.98
R9599:Zfp62 UTSW 11 49,106,542 (GRCm39) missense probably damaging 1.00
R9640:Zfp62 UTSW 11 49,106,458 (GRCm39) missense probably benign 0.21
R9781:Zfp62 UTSW 11 49,106,297 (GRCm39) nonsense probably null
X0011:Zfp62 UTSW 11 49,106,425 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACTGCAACTCCCTGCCTGATTC -3'
(R):5'- GCTGCGTTTGTATGTGTGTCAATCAT -3'

Sequencing Primer
(F):5'- tcctccaagaaagcaaaaacac -3'
(R):5'- TGTGTCAATCATTTCTCTGATACTAC -3'
Posted On 2014-01-29