Mutagenetix > Incidental Mutation

Incidental Mutation 'R1237:Vmn2r107'

152479

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

039304-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.156) question?

Stock #

R1237 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20565687-20596034 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 20576947 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 315 (L315*)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably null
Transcript: ENSMUST00000042090
AA Change: L315*

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: L315*

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.9%
20x: 91.8%

Validation Efficiency

98% (40/41)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	C	5: 105,096,223 (GRCm39)	T500A	probably damaging	Het
Amz1	A	T	5: 140,727,039 (GRCm39)	M1L	probably damaging	Het
Angptl1	T	A	1: 156,686,154 (GRCm39)	N413K	probably damaging	Het
Ankrd13b	T	C	11: 77,365,400 (GRCm39)	T70A	probably damaging	Het
Cacna1c	C	T	6: 118,589,586 (GRCm39)	R1446H	probably damaging	Het
Ccdc174	C	T	6: 91,867,768 (GRCm39)		probably benign	Het
Ccnc	T	A	4: 21,730,457 (GRCm39)	F31L	probably benign	Het
Celsr1	A	C	15: 85,788,175 (GRCm39)	S2692R	probably benign	Het
Chd1l	C	T	3: 97,490,047 (GRCm39)	E503K	probably benign	Het
Ddhd1	A	T	14: 45,839,107 (GRCm39)	D65E	probably benign	Het
Dync1h1	A	G	12: 110,632,393 (GRCm39)	N4504S	probably benign	Het
Enthd1	A	G	15: 80,418,799 (GRCm39)	S167P	probably damaging	Het
Fat1	A	T	8: 45,497,316 (GRCm39)	Y4267F	probably damaging	Het
Hectd4	C	T	5: 121,459,570 (GRCm39)	A813V	possibly damaging	Het
Ibtk	T	C	9: 85,602,801 (GRCm39)	S735G	probably benign	Het
Itga4	A	G	2: 79,109,490 (GRCm39)	I230V	probably null	Het
Kcnh8	A	T	17: 53,200,988 (GRCm39)	Q474L	probably damaging	Het
Kcnh8	G	T	17: 53,200,989 (GRCm39)	Q474H	probably damaging	Het
Mib1	C	T	18: 10,768,149 (GRCm39)	T466I	probably damaging	Het
Or12d12	T	A	17: 37,611,156 (GRCm39)	R52S	probably benign	Het
Or2ad1	C	T	13: 21,326,337 (GRCm39)	V297I	probably benign	Het
Or2l5	A	C	16: 19,334,375 (GRCm39)	Y4D	probably benign	Het
Parp14	G	A	16: 35,677,130 (GRCm39)	A946V	probably benign	Het
Prdx6b	A	G	2: 80,123,520 (GRCm39)	I110V	probably benign	Het
Prf1	A	C	10: 61,139,428 (GRCm39)	D462A	probably benign	Het
Rps6ka5	T	C	12: 100,541,964 (GRCm39)	D391G	possibly damaging	Het
Scn7a	A	T	2: 66,510,639 (GRCm39)	N1254K	probably damaging	Het
Skor2	A	T	18: 76,963,827 (GRCm39)	K924*	probably null	Het
Slc22a21	A	G	11: 53,870,598 (GRCm39)	I29T	probably benign	Het
Tas2r140	T	C	6: 133,032,171 (GRCm39)	T196A	probably benign	Het
Thrap3	A	G	4: 126,073,862 (GRCm39)	S295P	probably benign	Het
Trim43a	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	GATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATT	9: 88,465,042 (GRCm39)		probably benign	Het
Ubtd2	C	T	11: 32,466,125 (GRCm39)	R115W	probably damaging	Het
Unc93b1	A	G	19: 3,985,228 (GRCm39)	E12G	possibly damaging	Het
Vgll3	T	A	16: 65,636,459 (GRCm39)	Y203*	probably null	Het
Vmn1r212	G	A	13: 23,067,638 (GRCm39)	Q232*	probably null	Het
Vmn2r84	T	A	10: 130,223,725 (GRCm39)		probably null	Het
Washc5	A	G	15: 59,210,757 (GRCm39)		probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20,596,009 (GRCm39)	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20,565,868 (GRCm39)	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20,578,062 (GRCm39)	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20,595,168 (GRCm39)	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20,577,039 (GRCm39)	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20,595,823 (GRCm39)	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20,577,006 (GRCm39)	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20,578,017 (GRCm39)	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20,595,974 (GRCm39)	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20,577,173 (GRCm39)	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20,577,038 (GRCm39)	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20,578,220 (GRCm39)	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20,565,766 (GRCm39)	missense	probably benign
BB006:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20,565,873 (GRCm39)	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20,595,085 (GRCm39)	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20,595,394 (GRCm39)	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20,578,021 (GRCm39)	missense	probably benign
R0621:Vmn2r107	UTSW	17	20,595,252 (GRCm39)	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20,575,916 (GRCm39)	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20,576,860 (GRCm39)	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20,578,031 (GRCm39)	missense	probably benign
R1485:Vmn2r107	UTSW	17	20,595,109 (GRCm39)	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20,576,775 (GRCm39)	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20,565,840 (GRCm39)	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20,575,879 (GRCm39)	splice site	probably null
R2009:Vmn2r107	UTSW	17	20,595,729 (GRCm39)	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20,595,549 (GRCm39)	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20,595,904 (GRCm39)	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20,595,817 (GRCm39)	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20,580,607 (GRCm39)	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20,595,151 (GRCm39)	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20,595,717 (GRCm39)	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20,595,483 (GRCm39)	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20,576,041 (GRCm39)	missense	probably benign
R4963:Vmn2r107	UTSW	17	20,595,403 (GRCm39)	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20,576,015 (GRCm39)	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20,595,426 (GRCm39)	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20,595,316 (GRCm39)	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20,565,849 (GRCm39)	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20,576,044 (GRCm39)	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20,595,939 (GRCm39)	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20,595,637 (GRCm39)	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20,577,141 (GRCm39)	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20,576,138 (GRCm39)	missense	probably benign
R7448:Vmn2r107	UTSW	17	20,595,994 (GRCm39)	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20,595,271 (GRCm39)	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20,595,634 (GRCm39)	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20,580,635 (GRCm39)	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20,576,901 (GRCm39)	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20,577,270 (GRCm39)	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20,595,808 (GRCm39)	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20,580,614 (GRCm39)	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20,577,239 (GRCm39)	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20,577,051 (GRCm39)	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20,595,149 (GRCm39)	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20,580,661 (GRCm39)	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20,577,262 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20,577,230 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- GCTCCCAAGGACACATCTCTTTCAC -3'
(R):5'- AGCCACAGCGTACACAGCATTG -3'

Sequencing Primer
(F):5'- ATGATTCCTGCCACATGGAC -3'
(R):5'- CCAAAGAAGCATTTGTTTGACAGC -3'

Posted On

2014-01-29