Incidental Mutation 'V7582:Zfp933'
ID |
152599 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp933
|
Ensembl Gene |
ENSMUSG00000059423 |
Gene Name |
zinc finger protein 933 |
Synonyms |
2810408P10Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.063)
|
Stock # |
V7582 ()
of strain
stinger
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
147907443-147932823 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 147910927 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Valine
at position 223
(A223V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101343
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105718]
[ENSMUST00000135798]
|
AlphaFold |
Q6PEE4 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000105718
AA Change: A223V
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000101343 Gene: ENSMUSG00000059423 AA Change: A223V
Domain | Start | End | E-Value | Type |
KRAB
|
4 |
66 |
9.49e-16 |
SMART |
ZnF_C2H2
|
131 |
153 |
3.21e-4 |
SMART |
ZnF_C2H2
|
159 |
181 |
5.21e-4 |
SMART |
ZnF_C2H2
|
187 |
209 |
2.12e-4 |
SMART |
ZnF_C2H2
|
215 |
237 |
7.26e-3 |
SMART |
ZnF_C2H2
|
243 |
265 |
6.88e-4 |
SMART |
ZnF_C2H2
|
271 |
293 |
1.13e-4 |
SMART |
ZnF_C2H2
|
299 |
321 |
3.95e-4 |
SMART |
ZnF_C2H2
|
327 |
349 |
1.56e-2 |
SMART |
ZnF_C2H2
|
355 |
377 |
1.79e-2 |
SMART |
ZnF_C2H2
|
383 |
405 |
4.24e-4 |
SMART |
ZnF_C2H2
|
411 |
433 |
1.22e-4 |
SMART |
ZnF_C2H2
|
439 |
461 |
4.79e-3 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000116174
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000135798
|
SMART Domains |
Protein: ENSMUSP00000118300 Gene: ENSMUSG00000059423
Domain | Start | End | E-Value | Type |
Blast:KRAB
|
1 |
34 |
8e-18 |
BLAST |
PDB:2I13|B
|
32 |
98 |
1e-12 |
PDB |
SCOP:d1fgja_
|
33 |
98 |
5e-13 |
SMART |
Blast:PHD
|
44 |
98 |
6e-11 |
BLAST |
|
Meta Mutation Damage Score |
0.2168 |
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.7%
- 20x: 90.3%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9530002B09Rik |
A |
T |
4: 122,595,050 (GRCm39) |
H102L |
possibly damaging |
Het |
Ahcy |
G |
A |
2: 154,906,841 (GRCm39) |
R151* |
probably null |
Het |
Atp6v1h |
A |
G |
1: 5,194,666 (GRCm39) |
T282A |
possibly damaging |
Het |
Cdc42bpb |
C |
T |
12: 111,262,825 (GRCm39) |
G1501S |
probably benign |
Het |
Dnajc22 |
T |
A |
15: 98,999,363 (GRCm39) |
Y183N |
probably damaging |
Het |
Dpyd |
C |
T |
3: 118,690,775 (GRCm39) |
Q295* |
probably null |
Het |
Dync2i1 |
A |
C |
12: 116,175,460 (GRCm39) |
S906A |
possibly damaging |
Het |
Erv3 |
T |
C |
2: 131,697,846 (GRCm39) |
H171R |
possibly damaging |
Het |
Fam221b |
T |
C |
4: 43,665,865 (GRCm39) |
T249A |
probably benign |
Het |
Fbrsl1 |
C |
T |
5: 110,527,292 (GRCm39) |
A129T |
possibly damaging |
Het |
Fcgr1 |
T |
C |
3: 96,191,592 (GRCm39) |
*405W |
probably null |
Het |
Gm4787 |
G |
A |
12: 81,424,341 (GRCm39) |
Q606* |
probably null |
Het |
Hira |
G |
A |
16: 18,713,571 (GRCm39) |
A29T |
probably damaging |
Het |
Izumo4 |
A |
T |
10: 80,539,725 (GRCm39) |
T155S |
probably benign |
Het |
Kcnb2 |
A |
G |
1: 15,780,315 (GRCm39) |
I396V |
probably benign |
Het |
Lpar5 |
C |
A |
6: 125,058,690 (GRCm39) |
A137E |
possibly damaging |
Het |
Lrp4 |
C |
T |
2: 91,318,863 (GRCm39) |
S900L |
possibly damaging |
Het |
Med20 |
G |
A |
17: 47,929,757 (GRCm39) |
V65M |
probably damaging |
Het |
Myrfl |
T |
C |
10: 116,697,435 (GRCm39) |
T30A |
probably damaging |
Het |
Or10j7 |
G |
T |
1: 173,011,531 (GRCm39) |
L157I |
probably benign |
Het |
Otop3 |
T |
A |
11: 115,235,664 (GRCm39) |
L432Q |
probably damaging |
Het |
Papln |
C |
T |
12: 83,825,608 (GRCm39) |
R608C |
possibly damaging |
Het |
Pelp1 |
T |
A |
11: 70,288,976 (GRCm39) |
T257S |
probably damaging |
Het |
Pik3cd |
A |
C |
4: 149,741,776 (GRCm39) |
L390R |
probably damaging |
Het |
Plekhb1 |
T |
C |
7: 100,303,825 (GRCm39) |
T112A |
probably benign |
Het |
Rbbp8nl |
T |
A |
2: 179,920,001 (GRCm39) |
T558S |
probably benign |
Het |
Rundc3b |
TGCCGCCGCCGCCGCCGCCGCCGCCGC |
TGCCGCCGCCGCCGCCGCCGCCGC |
5: 8,672,549 (GRCm39) |
|
probably benign |
Het |
Slc30a4 |
T |
A |
2: 122,531,458 (GRCm39) |
M136L |
probably benign |
Het |
Spaca1 |
T |
C |
4: 34,039,311 (GRCm39) |
E192G |
probably damaging |
Het |
Thbd |
A |
T |
2: 148,249,110 (GRCm39) |
Y253N |
probably benign |
Het |
Tiam1 |
C |
T |
16: 89,662,159 (GRCm39) |
R653H |
probably damaging |
Het |
Tnrc6c |
G |
A |
11: 117,614,152 (GRCm39) |
R770H |
probably damaging |
Het |
Toe1 |
A |
T |
4: 116,663,308 (GRCm39) |
N56K |
probably damaging |
Het |
Tprkb |
A |
G |
6: 85,905,764 (GRCm39) |
K150E |
probably damaging |
Het |
Zfp292 |
C |
T |
4: 34,806,783 (GRCm39) |
C2087Y |
possibly damaging |
Het |
|
Other mutations in Zfp933 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00576:Zfp933
|
APN |
4 |
147,910,778 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03377:Zfp933
|
APN |
4 |
147,913,168 (GRCm39) |
missense |
possibly damaging |
0.65 |
F5770:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
FR4340:Zfp933
|
UTSW |
4 |
147,910,186 (GRCm39) |
frame shift |
probably null |
|
FR4548:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
R0388:Zfp933
|
UTSW |
4 |
147,910,899 (GRCm39) |
missense |
probably benign |
0.35 |
R0523:Zfp933
|
UTSW |
4 |
147,910,919 (GRCm39) |
nonsense |
probably null |
|
R0539:Zfp933
|
UTSW |
4 |
147,911,005 (GRCm39) |
missense |
probably benign |
0.08 |
R1672:Zfp933
|
UTSW |
4 |
147,910,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R4049:Zfp933
|
UTSW |
4 |
147,910,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R4895:Zfp933
|
UTSW |
4 |
147,910,892 (GRCm39) |
nonsense |
probably null |
|
R5133:Zfp933
|
UTSW |
4 |
147,911,321 (GRCm39) |
missense |
probably benign |
|
R5786:Zfp933
|
UTSW |
4 |
147,912,864 (GRCm39) |
splice site |
probably null |
|
R5891:Zfp933
|
UTSW |
4 |
147,911,231 (GRCm39) |
missense |
probably benign |
0.03 |
R6111:Zfp933
|
UTSW |
4 |
147,913,217 (GRCm39) |
missense |
probably damaging |
1.00 |
R6382:Zfp933
|
UTSW |
4 |
147,910,325 (GRCm39) |
missense |
probably benign |
0.07 |
R6968:Zfp933
|
UTSW |
4 |
147,910,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R7195:Zfp933
|
UTSW |
4 |
147,910,636 (GRCm39) |
missense |
probably benign |
0.16 |
R7555:Zfp933
|
UTSW |
4 |
147,910,589 (GRCm39) |
missense |
probably damaging |
1.00 |
R7902:Zfp933
|
UTSW |
4 |
147,911,058 (GRCm39) |
missense |
probably damaging |
0.96 |
R8319:Zfp933
|
UTSW |
4 |
147,912,910 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8688:Zfp933
|
UTSW |
4 |
147,911,249 (GRCm39) |
missense |
probably benign |
0.14 |
R9019:Zfp933
|
UTSW |
4 |
147,911,021 (GRCm39) |
missense |
probably damaging |
1.00 |
RF024:Zfp933
|
UTSW |
4 |
147,910,898 (GRCm39) |
missense |
probably damaging |
1.00 |
RF028:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
RF035:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
makesense |
probably null |
|
RF043:Zfp933
|
UTSW |
4 |
147,910,188 (GRCm39) |
frame shift |
probably null |
|
V7581:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
V7583:Zfp933
|
UTSW |
4 |
147,910,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
|
Posted On |
2014-01-29 |