Mutagenetix > Incidental Mutation

Incidental Mutation 'R1081:Lypd10'

152694

Institutional Source

Beutler Lab

Gene Symbol

Lypd10

Ensembl Gene

ENSMUSG00000045587

Gene Name

Ly6/PLAUR domain containing 10

Synonyms

BC049730

MMRRC Submission

039167-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1081 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

24408667-24413960 bp(+) (GRCm39)

Type of Mutation

splice site (1481 bp from exon)

DNA Base Change (assembly)

T to C at 24412967 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051714] [ENSMUST00000205376] [ENSMUST00000205376] [ENSMUST00000206826]

AlphaFold

Q810N3

Predicted Effect

probably damaging
Transcript: ENSMUST00000051714
AA Change: L125P

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000053275
Gene: ENSMUSG00000045587
AA Change: L125P

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:UPAR_LY6	141	219	3.5e-12	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000205376

Predicted Effect

probably null
Transcript: ENSMUST00000205376

Predicted Effect

probably benign
Transcript: ENSMUST00000206826

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 96.0%
20x: 91.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700003E16Rik	A	G	6: 83,139,002 (GRCm39)	E309G	probably benign	Het
Abr	T	C	11: 76,346,441 (GRCm39)	K448E	probably damaging	Het
Atxn2l	T	C	7: 126,093,384 (GRCm39)	Y785C	probably damaging	Het
Atxn3	T	G	12: 101,900,608 (GRCm39)	D225A	probably damaging	Het
Cdh15	G	C	8: 123,584,234 (GRCm39)	E112Q	probably damaging	Het
Cntnap5c	A	G	17: 58,612,520 (GRCm39)	D853G	possibly damaging	Het
Dnah9	A	G	11: 65,975,703 (GRCm39)	Y1449H	probably damaging	Het
Dsc2	T	G	18: 20,166,352 (GRCm39)	T760P	probably damaging	Het
Dync2h1	A	T	9: 7,005,488 (GRCm39)		probably null	Het
Epg5	T	C	18: 78,002,748 (GRCm39)	F611L	possibly damaging	Het
Fat3	T	C	9: 16,286,580 (GRCm39)	D981G	possibly damaging	Het
Gimap3	A	T	6: 48,742,086 (GRCm39)	C281*	probably null	Het
Ids	T	C	X: 69,404,716 (GRCm39)	D149G	possibly damaging	Het
Inpp4b	A	G	8: 82,795,653 (GRCm39)	I826V	probably damaging	Het
Kcnrg	C	A	14: 61,845,163 (GRCm39)	H68N	possibly damaging	Het
Klra6	A	G	6: 129,999,588 (GRCm39)	Y127H	probably damaging	Het
Mepce	A	G	5: 137,782,958 (GRCm39)	L456P	probably damaging	Het
Mink1	T	C	11: 70,497,861 (GRCm39)	L488P	probably benign	Het
Mndal	T	A	1: 173,687,788 (GRCm39)	E482V	probably benign	Het
Mob1b	G	A	5: 88,901,021 (GRCm39)	V143I	probably benign	Het
Msh4	T	C	3: 153,577,995 (GRCm39)	E433G	probably benign	Het
Myof	A	T	19: 37,974,536 (GRCm39)	I201N	probably damaging	Het
Naip1	G	A	13: 100,559,578 (GRCm39)	S1142F	probably benign	Het
Ntsr1	G	A	2: 180,180,549 (GRCm39)	S285N	probably benign	Het
Or2ak6	C	T	11: 58,593,324 (GRCm39)	H266Y	probably damaging	Het
Or4k2	A	G	14: 50,424,654 (GRCm39)	S7P	probably damaging	Het
Or51b4	T	A	7: 103,531,384 (GRCm39)	H22L	possibly damaging	Het
Or52ab7	A	G	7: 102,978,245 (GRCm39)	Y184C	probably damaging	Het
P2rx4	A	G	5: 122,865,296 (GRCm39)	E307G	probably damaging	Het
Pcdh15	A	G	10: 74,286,145 (GRCm39)	D793G	probably damaging	Het
Rpap1	G	A	2: 119,601,750 (GRCm39)	R737W	probably damaging	Het
Rpusd4	A	G	9: 35,186,384 (GRCm39)	K307E	probably benign	Het
Shtn1	T	A	19: 58,963,447 (GRCm39)	T623S	probably benign	Het
Sntg1	A	G	1: 8,515,343 (GRCm39)	C397R	possibly damaging	Het
Stat5a	T	C	11: 100,771,886 (GRCm39)	F646S	probably damaging	Het
Tacc2	A	G	7: 130,330,304 (GRCm39)	E196G	possibly damaging	Het
Tcf25	T	C	8: 124,108,212 (GRCm39)	V89A	probably benign	Het
Trim7	G	T	11: 48,740,532 (GRCm39)	V210L	probably damaging	Het
Vmn2r57	A	G	7: 41,077,635 (GRCm39)	M177T	possibly damaging	Het
Wwc2	G	A	8: 48,281,799 (GRCm39)		probably benign	Het
Zfp28	A	G	7: 6,392,779 (GRCm39)	I152V	possibly damaging	Het
Zfp628	A	G	7: 4,923,182 (GRCm39)	H468R	probably damaging	Het
Zfp770	A	G	2: 114,027,608 (GRCm39)	Y154H	probably damaging	Het

Other mutations in Lypd10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00847:Lypd10	APN	7	24,413,673 (GRCm39)	missense	probably benign	0.01
IGL01353:Lypd10	APN	7	24,413,662 (GRCm39)	missense	probably damaging	0.98
IGL01603:Lypd10	APN	7	24,411,954 (GRCm39)	missense	probably damaging	1.00
IGL03084:Lypd10	APN	7	24,413,605 (GRCm39)	missense	possibly damaging	0.80
R0453:Lypd10	UTSW	7	24,413,712 (GRCm39)	missense	probably benign	0.18
R0657:Lypd10	UTSW	7	24,412,872 (GRCm39)	missense	probably benign	0.00
R0946:Lypd10	UTSW	7	24,413,167 (GRCm39)	missense	probably benign	0.00
R1076:Lypd10	UTSW	7	24,413,167 (GRCm39)	missense	probably benign	0.00
R1926:Lypd10	UTSW	7	24,413,541 (GRCm39)	missense	probably damaging	1.00
R2571:Lypd10	UTSW	7	24,412,819 (GRCm39)	missense	probably benign	0.27
R3014:Lypd10	UTSW	7	24,412,821 (GRCm39)	missense	possibly damaging	0.93
R3832:Lypd10	UTSW	7	24,413,712 (GRCm39)	missense	probably benign	0.18
R4197:Lypd10	UTSW	7	24,413,119 (GRCm39)	missense	probably benign	0.01
R4705:Lypd10	UTSW	7	24,412,934 (GRCm39)	missense	probably damaging	0.99
R5609:Lypd10	UTSW	7	24,413,711 (GRCm39)	missense	possibly damaging	0.53
R6166:Lypd10	UTSW	7	24,413,644 (GRCm39)	missense	probably benign	0.00
R6385:Lypd10	UTSW	7	24,413,535 (GRCm39)	missense	probably damaging	0.97
R7477:Lypd10	UTSW	7	24,413,673 (GRCm39)	missense	probably benign	0.01
R8022:Lypd10	UTSW	7	24,413,599 (GRCm39)	missense	possibly damaging	0.92
R8169:Lypd10	UTSW	7	24,412,000 (GRCm39)	missense	probably benign	0.15
R8695:Lypd10	UTSW	7	24,413,203 (GRCm39)	missense	probably benign	0.16
R9129:Lypd10	UTSW	7	24,413,170 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AAGAACTGGGCTGTTACCACTCGC -3'
(R):5'- GGCACAAGGTATGGTTGGACTCTG -3'

Sequencing Primer
(F):5'- ATGCCTCAATGTCACTCTTTTTTG -3'
(R):5'- TGGACTCTGTATTGCAAGAACCC -3'

Posted On

2014-01-29