Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01743:Or2ag1'

152898

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2ag1

Ensembl Gene

ENSMUSG00000109058

Gene Name

olfactory receptor family 2 subfamily AG member 1

Synonyms

Olfr705, MOR283-2, GA_x6K02T2PBJ9-9256348-9255398

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL01743

Quality Score

Status

Chromosome

Chromosomal Location

106472500-106473450 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106313541 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 116 (S116P)

Ref Sequence

ENSEMBL: ENSMUSP00000149773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080925] [ENSMUST00000216868]

AlphaFold

Q9EPF7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000080925
AA Change: S116P

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000079726
Gene: ENSMUSG00000073900
AA Change: S116P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.1e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.5e-7	PFAM
Pfam:7tm_1	41	290	1.5e-21	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216868
AA Change: S116P

PolyPhen 2 Score 0.478 (Sensitivity: 0.89; Specificity: 0.90)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	A	T	7: 45,646,238 (GRCm39)	N750K	probably benign	Het
Ackr2	T	C	9: 121,738,566 (GRCm39)	C314R	probably benign	Het
Adar	C	T	3: 89,652,747 (GRCm39)	Q210*	probably null	Het
Aifm1	A	G	X: 47,569,153 (GRCm39)		probably benign	Het
Aldoa	G	T	7: 126,395,875 (GRCm39)	D198E	probably damaging	Het
Ampd1	T	A	3: 103,002,201 (GRCm39)		probably benign	Het
Arhgef18	G	T	8: 3,414,697 (GRCm39)	C25F	probably benign	Het
Btnl1	T	C	17: 34,604,659 (GRCm39)	I480T	probably damaging	Het
Capn9	T	C	8: 125,318,508 (GRCm39)	S125P	probably benign	Het
Cd40lg	T	A	X: 56,257,592 (GRCm39)	Y26*	probably null	Het
Cdc42bpg	G	T	19: 6,359,853 (GRCm39)		probably null	Het
Cdh10	T	C	15: 18,986,855 (GRCm39)	L362P	probably benign	Het
Dhx16	A	G	17: 36,199,000 (GRCm39)	D782G	probably damaging	Het
Dnajb14	G	T	3: 137,611,761 (GRCm39)	V320L	possibly damaging	Het
Dpy19l1	C	T	9: 24,396,365 (GRCm39)	R117Q	probably damaging	Het
Ercc6	T	C	14: 32,274,561 (GRCm39)	V568A	probably damaging	Het
Faf2	T	C	13: 54,789,311 (GRCm39)		probably null	Het
Fbrsl1	C	T	5: 110,529,506 (GRCm39)	V223M	probably damaging	Het
Fcrl5	T	C	3: 87,351,598 (GRCm39)	V282A	probably damaging	Het
Fxr2	C	T	11: 69,543,448 (GRCm39)	L650F	possibly damaging	Het
Gabrq	A	G	X: 71,880,448 (GRCm39)	M314V	probably benign	Het
Gnas	T	A	2: 174,140,125 (GRCm39)	Y157*	probably null	Het
Gtf2i	T	C	5: 134,315,747 (GRCm39)	E175G	probably damaging	Het
Gtf3c1	A	C	7: 125,262,587 (GRCm39)	Y1091D	probably damaging	Het
Heatr5b	G	A	17: 79,132,069 (GRCm39)	Q345*	probably null	Het
Hydin	T	C	8: 111,319,408 (GRCm39)	V4437A	possibly damaging	Het
Idi2	T	A	13: 9,008,578 (GRCm39)	L112Q	probably damaging	Het
Ift80	C	T	3: 68,869,629 (GRCm39)	V221M	probably benign	Het
Il16	A	G	7: 83,301,507 (GRCm39)	F205S	probably benign	Het
Irf1	T	A	11: 53,665,277 (GRCm39)	M218K	probably benign	Het
Itga8	T	C	2: 12,270,144 (GRCm39)	N114S	probably benign	Het
Itgae	T	C	11: 73,002,585 (GRCm39)	V114A	probably benign	Het
Klhdc10	A	G	6: 30,441,933 (GRCm39)		probably null	Het
Krt78	C	A	15: 101,859,333 (GRCm39)	R288L	probably benign	Het
Lars2	A	T	9: 123,282,313 (GRCm39)	L632F	probably damaging	Het
Mpdz	T	C	4: 81,235,919 (GRCm39)	D1220G	probably damaging	Het
Msl1	C	T	11: 98,696,245 (GRCm39)	T597I	probably damaging	Het
Mtor	T	C	4: 148,615,070 (GRCm39)		probably benign	Het
Myo1b	T	C	1: 51,821,179 (GRCm39)	T435A	probably damaging	Het
Neb	A	G	2: 52,115,679 (GRCm39)	Y4176H	probably damaging	Het
Nxpe3	A	G	16: 55,670,128 (GRCm39)	F326L	probably benign	Het
Or13a21	T	C	7: 139,999,581 (GRCm39)	Y35C	probably damaging	Het
Pak5	T	A	2: 135,929,333 (GRCm39)	R617W	probably damaging	Het
Peak1	C	A	9: 56,166,486 (GRCm39)	V481L	probably damaging	Het
Pik3ap1	G	A	19: 41,281,267 (GRCm39)		probably benign	Het
Pmm1	C	T	15: 81,844,987 (GRCm39)	E6K	probably benign	Het
Ppp2r5c	G	A	12: 110,546,868 (GRCm39)	V454M	probably benign	Het
Ptprf	C	T	4: 118,106,095 (GRCm39)		probably null	Het
Pygm	G	A	19: 6,443,024 (GRCm39)		probably null	Het
Rimbp2	T	A	5: 128,874,912 (GRCm39)		probably benign	Het
Rps6ka5	A	T	12: 100,541,892 (GRCm39)		probably null	Het
Scarb2	A	G	5: 92,608,662 (GRCm39)	V188A	probably benign	Het
Sfrp1	T	A	8: 23,902,354 (GRCm39)		probably benign	Het
Siglec15	T	A	18: 78,086,820 (GRCm39)		probably benign	Het
Smgc	A	G	15: 91,738,796 (GRCm39)	I485V	probably benign	Het
Tas2r124	A	G	6: 132,731,798 (GRCm39)	I36V	probably benign	Het
Trmt10b	G	T	4: 45,305,879 (GRCm39)	G185W	probably damaging	Het
Ttll4	A	G	1: 74,727,352 (GRCm39)	N798S	possibly damaging	Het
Ttn	G	T	2: 76,619,896 (GRCm39)	T15924N	probably damaging	Het
Utrn	A	T	10: 12,587,301 (GRCm39)	Y912N	possibly damaging	Het
Vmn2r113	T	C	17: 23,177,285 (GRCm39)	Y690H	probably benign	Het
Vmn2r51	T	C	7: 9,834,154 (GRCm39)	R295G	probably damaging	Het
Vpreb3	A	G	10: 75,784,231 (GRCm39)	T14A	probably benign	Het

Other mutations in Or2ag1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02203:Or2ag1	APN	7	106,313,837 (GRCm39)	missense	probably benign	0.02
IGL02342:Or2ag1	APN	7	106,313,232 (GRCm39)	missense	probably benign	0.13
IGL02544:Or2ag1	APN	7	106,313,742 (GRCm39)	missense	probably benign	0.39
IGL02569:Or2ag1	APN	7	106,313,793 (GRCm39)	missense	probably benign	0.00
PIT4651001:Or2ag1	UTSW	7	106,472,730 (GRCm39)	missense	probably damaging	1.00
R0501:Or2ag1	UTSW	7	106,313,810 (GRCm39)	missense	probably benign	0.01
R0504:Or2ag1	UTSW	7	106,313,908 (GRCm39)	splice site	probably benign
R0536:Or2ag1	UTSW	7	106,313,528 (GRCm39)	missense	probably damaging	1.00
R0633:Or2ag1	UTSW	7	106,313,184 (GRCm39)	missense	probably benign	0.03
R0686:Or2ag1	UTSW	7	106,313,585 (GRCm39)	missense	probably damaging	0.98
R1225:Or2ag1	UTSW	7	106,313,731 (GRCm39)	missense	probably benign	0.22
R1725:Or2ag1	UTSW	7	106,313,265 (GRCm39)	missense	probably benign
R1864:Or2ag1	UTSW	7	106,313,030 (GRCm39)	missense	possibly damaging	0.87
R2065:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	probably benign	0.12
R2068:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	probably benign	0.12
R2081:Or2ag1	UTSW	7	106,313,405 (GRCm39)	missense	probably benign
R4135:Or2ag1	UTSW	7	106,313,210 (GRCm39)	missense	probably damaging	1.00
R5649:Or2ag1	UTSW	7	106,313,373 (GRCm39)	missense	possibly damaging	0.89
R5858:Or2ag1	UTSW	7	106,472,975 (GRCm39)	missense	probably benign	0.01
R6083:Or2ag1	UTSW	7	106,472,789 (GRCm39)	missense	probably damaging	0.98
R7144:Or2ag1	UTSW	7	106,473,075 (GRCm39)	missense	probably damaging	1.00
R7214:Or2ag1	UTSW	7	106,473,474 (GRCm39)	start gained	probably benign
R7366:Or2ag1	UTSW	7	106,472,603 (GRCm39)	missense	probably damaging	1.00
R7445:Or2ag1	UTSW	7	106,472,549 (GRCm39)	missense	possibly damaging	0.55
R8171:Or2ag1	UTSW	7	106,313,826 (GRCm39)	missense
R8171:Or2ag1	UTSW	7	106,313,825 (GRCm39)	missense	probably benign
R8986:Or2ag1	UTSW	7	106,473,050 (GRCm39)	missense	probably benign	0.00
R9285:Or2ag1	UTSW	7	106,472,715 (GRCm39)	missense	probably benign	0.11

Posted On

2014-02-04