Incidental Mutation 'IGL01745:Or5g26'
ID 152997
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5g26
Ensembl Gene ENSMUSG00000075212
Gene Name olfactory receptor family 5 subfamily G member 26
Synonyms MOR175-1, Olfr154, 912-93, Olfr4-3, OR93, GA_x6K02T2Q125-47143827-47142871
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # IGL01745
Quality Score
Status
Chromosome 2
Chromosomal Location 85493721-85494799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85493921 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 286 (N286D)
Ref Sequence ENSEMBL: ENSMUSP00000097502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099918]
AlphaFold Q9QY00
Predicted Effect possibly damaging
Transcript: ENSMUST00000099918
AA Change: N286D

PolyPhen 2 Score 0.763 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097502
Gene: ENSMUSG00000075212
AA Change: N286D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-49 PFAM
Pfam:7tm_1 41 290 1.7e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc153 T G 9: 44,154,408 (GRCm39) S56R possibly damaging Het
Chct1 A G 11: 85,063,696 (GRCm39) T30A probably benign Het
D630045J12Rik T C 6: 38,168,655 (GRCm39) K965E probably damaging Het
F2rl1 A G 13: 95,650,261 (GRCm39) V207A probably benign Het
Matn4 A G 2: 164,242,663 (GRCm39) V145A probably damaging Het
Mllt6 T G 11: 97,567,754 (GRCm39) L757R probably damaging Het
Or2at4 A G 7: 99,384,595 (GRCm39) T82A probably damaging Het
Or5m3b T A 2: 85,872,381 (GRCm39) S241T possibly damaging Het
Prrc2c A G 1: 162,552,297 (GRCm39) S30P probably damaging Het
Setd2 T C 9: 110,423,779 (GRCm39) V2278A probably damaging Het
Slco4a1 G A 2: 180,106,472 (GRCm39) C218Y probably damaging Het
Vps35 A T 8: 86,000,092 (GRCm39) probably benign Het
Zfp593 A G 4: 133,972,355 (GRCm39) S82P probably damaging Het
Other mutations in Or5g26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Or5g26 APN 2 85,494,700 (GRCm39) missense probably benign 0.23
R1937:Or5g26 UTSW 2 85,494,341 (GRCm39) missense probably benign
R2086:Or5g26 UTSW 2 85,494,090 (GRCm39) missense probably benign
R2876:Or5g26 UTSW 2 85,494,034 (GRCm39) missense probably damaging 1.00
R3881:Or5g26 UTSW 2 85,494,769 (GRCm39) missense probably benign 0.00
R4801:Or5g26 UTSW 2 85,494,622 (GRCm39) missense probably damaging 1.00
R4802:Or5g26 UTSW 2 85,494,622 (GRCm39) missense probably damaging 1.00
R6010:Or5g26 UTSW 2 85,494,374 (GRCm39) missense probably benign 0.00
R6944:Or5g26 UTSW 2 85,494,195 (GRCm39) missense probably benign 0.00
R7089:Or5g26 UTSW 2 85,494,518 (GRCm39) missense possibly damaging 0.79
R7443:Or5g26 UTSW 2 85,493,912 (GRCm39) missense probably damaging 1.00
R7453:Or5g26 UTSW 2 85,494,524 (GRCm39) missense probably benign
R7736:Or5g26 UTSW 2 85,494,758 (GRCm39) missense probably damaging 1.00
R7853:Or5g26 UTSW 2 85,494,689 (GRCm39) missense probably benign
R9719:Or5g26 UTSW 2 85,494,608 (GRCm39) missense probably benign 0.30
Z1088:Or5g26 UTSW 2 85,493,960 (GRCm39) missense probably benign 0.02
Posted On 2014-02-04