Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01747:Trappc11'

153044

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trappc11

Ensembl Gene

ENSMUSG00000038102

Gene Name

trafficking protein particle complex 11

Synonyms

D030016E14Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01747

Quality Score

Status

Chromosome

Chromosomal Location

47943163-47986505 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 47972656 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 306 (I306V)

Ref Sequence

ENSEMBL: ENSMUSP00000047562 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039061]

AlphaFold

B2RXC1

Predicted Effect

probably benign
Transcript: ENSMUST00000039061
AA Change: I306V

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000047562
Gene: ENSMUSG00000038102
AA Change: I306V

Domain	Start	End	E-Value	Type
Pfam:Foie-gras_1	263	522	3e-78	PFAM
Pfam:Gryzun	978	1114	3.9e-10	PFAM
Pfam:Gryzun-like	1036	1095	2.4e-28	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123958

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833439L19Rik	A	G	13: 54,704,338 (GRCm39)		probably null	Het
Abca14	A	G	7: 119,877,310 (GRCm39)	N986S	probably benign	Het
Adamts17	G	A	7: 66,701,759 (GRCm39)	G702D	probably damaging	Het
Aox3	G	A	1: 58,198,817 (GRCm39)	V671M	probably damaging	Het
Asnsd1	A	T	1: 53,387,254 (GRCm39)	Y124*	probably null	Het
Astn2	A	T	4: 65,712,855 (GRCm39)	M595K	probably benign	Het
Col2a1	T	C	15: 97,889,273 (GRCm39)		probably benign	Het
Dhrs2	A	T	14: 55,472,120 (GRCm39)	I4L	probably benign	Het
Fbxo4	A	T	15: 3,995,237 (GRCm39)	L369*	probably null	Het
Gpbp1	G	A	13: 111,589,584 (GRCm39)	R129C	probably damaging	Het
Lrp1b	T	A	2: 40,750,697 (GRCm39)	I2956L	probably damaging	Het
Myo16	C	T	8: 10,654,877 (GRCm39)	T1843I	probably damaging	Het
Or1j14	T	C	2: 36,417,844 (GRCm39)	L140P	probably damaging	Het
Or8k3b	T	C	2: 86,521,045 (GRCm39)	I91M	possibly damaging	Het
Pcdhb2	T	G	18: 37,429,356 (GRCm39)	V86G	probably damaging	Het
Pskh1	T	C	8: 106,639,836 (GRCm39)	M172T	probably damaging	Het
Slc38a10	T	C	11: 120,025,600 (GRCm39)		probably benign	Het
Spry2	C	T	14: 106,130,488 (GRCm39)	D233N	probably damaging	Het
Tmem163	T	A	1: 127,596,457 (GRCm39)	R84W	probably damaging	Het
Virma	T	C	4: 11,526,877 (GRCm39)	L1092P	probably damaging	Het
Vmn2r98	A	G	17: 19,286,702 (GRCm39)	Y400C	probably damaging	Het

Other mutations in Trappc11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Trappc11	APN	8	47,956,337 (GRCm39)	unclassified	probably benign
IGL01300:Trappc11	APN	8	47,954,903 (GRCm39)	missense	probably benign
IGL01312:Trappc11	APN	8	47,958,712 (GRCm39)	missense	possibly damaging	0.95
IGL01344:Trappc11	APN	8	47,972,739 (GRCm39)	missense	probably damaging	1.00
IGL01518:Trappc11	APN	8	47,954,904 (GRCm39)	splice site	probably null
IGL01781:Trappc11	APN	8	47,967,163 (GRCm39)	missense	possibly damaging	0.95
IGL01908:Trappc11	APN	8	47,957,029 (GRCm39)	missense	probably damaging	1.00
IGL01956:Trappc11	APN	8	47,981,036 (GRCm39)	missense	possibly damaging	0.86
IGL02266:Trappc11	APN	8	47,958,766 (GRCm39)	missense	probably damaging	1.00
IGL02377:Trappc11	APN	8	47,983,685 (GRCm39)	critical splice donor site	probably null
IGL02530:Trappc11	APN	8	47,960,617 (GRCm39)	missense	probably damaging	1.00
IGL02676:Trappc11	APN	8	47,946,448 (GRCm39)	splice site	probably benign
IGL03030:Trappc11	APN	8	47,966,964 (GRCm39)	missense	probably damaging	0.98
IGL03393:Trappc11	APN	8	47,963,912 (GRCm39)	missense	possibly damaging	0.95
bantu	UTSW	8	47,951,701 (GRCm39)	missense	probably benign	0.44
bunyoro	UTSW	8	47,965,320 (GRCm39)	splice site	probably null
nyoro	UTSW	8	47,980,014 (GRCm39)	missense	possibly damaging	0.73
serval	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R0009:Trappc11	UTSW	8	47,956,355 (GRCm39)	missense	possibly damaging	0.70
R0009:Trappc11	UTSW	8	47,956,355 (GRCm39)	missense	possibly damaging	0.70
R0043:Trappc11	UTSW	8	47,958,610 (GRCm39)	splice site	probably benign
R0180:Trappc11	UTSW	8	47,981,009 (GRCm39)	missense	possibly damaging	0.86
R0529:Trappc11	UTSW	8	47,980,014 (GRCm39)	missense	possibly damaging	0.73
R0538:Trappc11	UTSW	8	47,956,447 (GRCm39)	missense	probably benign	0.01
R0740:Trappc11	UTSW	8	47,977,623 (GRCm39)	missense	probably damaging	0.99
R1352:Trappc11	UTSW	8	47,978,081 (GRCm39)	missense	possibly damaging	0.90
R1469:Trappc11	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R1469:Trappc11	UTSW	8	47,957,000 (GRCm39)	missense	probably damaging	1.00
R1502:Trappc11	UTSW	8	47,983,862 (GRCm39)	missense	possibly damaging	0.94
R1589:Trappc11	UTSW	8	47,954,715 (GRCm39)	missense	probably damaging	1.00
R1741:Trappc11	UTSW	8	47,982,362 (GRCm39)	critical splice donor site	probably null
R2292:Trappc11	UTSW	8	47,958,771 (GRCm39)	missense	probably damaging	1.00
R2303:Trappc11	UTSW	8	47,956,451 (GRCm39)	missense	probably damaging	0.99
R2931:Trappc11	UTSW	8	47,956,977 (GRCm39)	missense	probably damaging	0.99
R3522:Trappc11	UTSW	8	47,951,708 (GRCm39)	missense	possibly damaging	0.93
R3714:Trappc11	UTSW	8	47,958,351 (GRCm39)	intron	probably benign
R3739:Trappc11	UTSW	8	47,967,138 (GRCm39)	missense	probably damaging	0.98
R4165:Trappc11	UTSW	8	47,978,003 (GRCm39)	splice site	probably benign
R4581:Trappc11	UTSW	8	47,946,380 (GRCm39)	missense	probably damaging	0.97
R4598:Trappc11	UTSW	8	47,966,801 (GRCm39)	missense	probably damaging	0.98
R4939:Trappc11	UTSW	8	47,972,700 (GRCm39)	missense	probably damaging	1.00
R4990:Trappc11	UTSW	8	47,943,930 (GRCm39)	missense	probably benign	0.41
R4994:Trappc11	UTSW	8	47,975,476 (GRCm39)	nonsense	probably null
R5091:Trappc11	UTSW	8	47,965,639 (GRCm39)	missense	probably benign	0.00
R5123:Trappc11	UTSW	8	47,966,437 (GRCm39)	missense	probably damaging	0.99
R5176:Trappc11	UTSW	8	47,963,998 (GRCm39)	missense	possibly damaging	0.79
R5279:Trappc11	UTSW	8	47,958,339 (GRCm39)	intron	probably benign
R5293:Trappc11	UTSW	8	47,946,377 (GRCm39)	missense	possibly damaging	0.83
R5294:Trappc11	UTSW	8	47,983,766 (GRCm39)	missense	possibly damaging	0.88
R5661:Trappc11	UTSW	8	47,965,642 (GRCm39)	missense	probably damaging	0.99
R5838:Trappc11	UTSW	8	47,965,594 (GRCm39)	critical splice donor site	probably null
R5889:Trappc11	UTSW	8	47,972,613 (GRCm39)	missense	probably benign	0.40
R5952:Trappc11	UTSW	8	47,949,952 (GRCm39)	critical splice donor site	probably null
R5959:Trappc11	UTSW	8	47,954,593 (GRCm39)	missense	probably damaging	0.97
R6239:Trappc11	UTSW	8	47,982,529 (GRCm39)	missense	possibly damaging	0.73
R6322:Trappc11	UTSW	8	47,983,808 (GRCm39)	missense	possibly damaging	0.95
R6369:Trappc11	UTSW	8	47,965,320 (GRCm39)	splice site	probably null
R7541:Trappc11	UTSW	8	47,958,617 (GRCm39)	splice site	probably null
R7544:Trappc11	UTSW	8	47,975,449 (GRCm39)	missense	possibly damaging	0.73
R7762:Trappc11	UTSW	8	47,975,411 (GRCm39)	missense	probably damaging	0.99
R7964:Trappc11	UTSW	8	47,979,979 (GRCm39)	missense	possibly damaging	0.54
R8183:Trappc11	UTSW	8	47,982,391 (GRCm39)	missense	possibly damaging	0.93
R8282:Trappc11	UTSW	8	47,969,624 (GRCm39)	missense	probably damaging	0.97
R8733:Trappc11	UTSW	8	47,954,883 (GRCm39)	missense	probably damaging	1.00
R8782:Trappc11	UTSW	8	47,951,701 (GRCm39)	missense	probably benign	0.44
R8853:Trappc11	UTSW	8	47,982,439 (GRCm39)	missense	probably damaging	0.98
R9544:Trappc11	UTSW	8	47,972,713 (GRCm39)	missense	possibly damaging	0.94
R9709:Trappc11	UTSW	8	47,946,348 (GRCm39)	missense	probably damaging	0.97

Posted On

2014-02-04