Incidental Mutation 'IGL01748:Foxred2'
| ID |
153072 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Foxred2
|
| Ensembl Gene |
ENSMUSG00000016552 |
| Gene Name |
FAD-dependent oxidoreductase domain containing 2 |
| Synonyms |
D15Bwg0759e, A430097D04Rik, LOC239554 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01748
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
77824722-77840922 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 77836546 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 323
(D323G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113403
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000016696]
[ENSMUST00000117725]
|
| AlphaFold |
Q3USW5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000016696
AA Change: D323G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000016696
Gene: ENSMUSG00000016552
AA Change: D323G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:Pyr_redox_2
|
22 |
243 |
2.9e-11 |
PFAM |
|
Pfam:Pyr_redox_3
|
25 |
240 |
9.3e-35 |
PFAM |
|
Pfam:NAD_binding_8
|
26 |
84 |
3.3e-6 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117725
AA Change: D323G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113403
Gene: ENSMUSG00000016552
AA Change: D323G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:Pyr_redox_2
|
23 |
478 |
3.4e-9 |
PFAM |
|
Pfam:Pyr_redox_3
|
25 |
240 |
6.2e-37 |
PFAM |
|
Pfam:NAD_binding_8
|
26 |
90 |
4.8e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129045
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb1 |
T |
C |
15: 74,420,206 (GRCm39) |
|
probably benign |
Het |
| Asb1 |
G |
A |
1: 91,480,008 (GRCm39) |
V236I |
probably damaging |
Het |
| Bod1l |
G |
A |
5: 41,974,304 (GRCm39) |
R2337C |
probably benign |
Het |
| Fermt3 |
A |
T |
19: 6,980,834 (GRCm39) |
|
probably null |
Het |
| Fry |
A |
G |
5: 150,269,116 (GRCm39) |
|
probably benign |
Het |
| Galnt11 |
T |
A |
5: 25,452,513 (GRCm39) |
Y8* |
probably null |
Het |
| Gm42688 |
T |
A |
6: 83,080,001 (GRCm39) |
S275T |
possibly damaging |
Het |
| Grip2 |
C |
T |
6: 91,741,724 (GRCm39) |
G934R |
probably damaging |
Het |
| Igkv1-122 |
G |
T |
6: 67,994,456 (GRCm39) |
V115F |
possibly damaging |
Het |
| Iglon5 |
C |
T |
7: 43,125,953 (GRCm39) |
|
probably benign |
Het |
| Nbl1 |
G |
T |
4: 138,810,921 (GRCm39) |
|
probably benign |
Het |
| Nup107 |
A |
G |
10: 117,593,179 (GRCm39) |
V833A |
probably benign |
Het |
| Or4k41 |
T |
C |
2: 111,279,875 (GRCm39) |
L130P |
probably damaging |
Het |
| Psg18 |
T |
C |
7: 18,087,476 (GRCm39) |
N61D |
probably benign |
Het |
| Rfng |
A |
G |
11: 120,674,569 (GRCm39) |
M104T |
probably benign |
Het |
| Scn10a |
A |
G |
9: 119,456,150 (GRCm39) |
F1224S |
probably damaging |
Het |
| Strn4 |
C |
T |
7: 16,572,227 (GRCm39) |
P647S |
probably damaging |
Het |
| Tbc1d2 |
A |
G |
4: 46,616,306 (GRCm39) |
V474A |
probably damaging |
Het |
| Trav13n-4 |
A |
T |
14: 53,601,470 (GRCm39) |
T80S |
probably benign |
Het |
| Trrap |
A |
G |
5: 144,770,150 (GRCm39) |
E2757G |
probably damaging |
Het |
| Vmn1r43 |
G |
T |
6: 89,847,294 (GRCm39) |
T64N |
probably damaging |
Het |
| Vmn2r108 |
A |
T |
17: 20,683,476 (GRCm39) |
I576N |
probably benign |
Het |
| Vmn2r65 |
A |
T |
7: 84,589,507 (GRCm39) |
I803N |
probably damaging |
Het |
| Zfp341 |
T |
C |
2: 154,470,847 (GRCm39) |
V288A |
probably damaging |
Het |
|
| Other mutations in Foxred2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01394:Foxred2
|
APN |
15 |
77,839,820 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01479:Foxred2
|
APN |
15 |
77,836,489 (GRCm39) |
splice site |
probably null |
|
|
IGL02160:Foxred2
|
APN |
15 |
77,839,850 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02328:Foxred2
|
APN |
15 |
77,840,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02630:Foxred2
|
APN |
15 |
77,831,362 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02672:Foxred2
|
APN |
15 |
77,829,777 (GRCm39) |
critical splice donor site |
probably null |
|
|
soma
|
UTSW |
15 |
77,837,558 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0271:Foxred2
|
UTSW |
15 |
77,827,590 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1386:Foxred2
|
UTSW |
15 |
77,832,721 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1581:Foxred2
|
UTSW |
15 |
77,839,961 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4399:Foxred2
|
UTSW |
15 |
77,839,880 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4399:Foxred2
|
UTSW |
15 |
77,837,558 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4528:Foxred2
|
UTSW |
15 |
77,827,449 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4937:Foxred2
|
UTSW |
15 |
77,840,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5165:Foxred2
|
UTSW |
15 |
77,840,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Foxred2
|
UTSW |
15 |
77,836,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5893:Foxred2
|
UTSW |
15 |
77,831,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6336:Foxred2
|
UTSW |
15 |
77,839,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6370:Foxred2
|
UTSW |
15 |
77,827,506 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6426:Foxred2
|
UTSW |
15 |
77,837,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Foxred2
|
UTSW |
15 |
77,831,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6891:Foxred2
|
UTSW |
15 |
77,839,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6934:Foxred2
|
UTSW |
15 |
77,836,530 (GRCm39) |
nonsense |
probably null |
|
|
R7193:Foxred2
|
UTSW |
15 |
77,836,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7821:Foxred2
|
UTSW |
15 |
77,827,550 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8401:Foxred2
|
UTSW |
15 |
77,836,191 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8540:Foxred2
|
UTSW |
15 |
77,836,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8844:Foxred2
|
UTSW |
15 |
77,832,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8916:Foxred2
|
UTSW |
15 |
77,837,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Foxred2
|
UTSW |
15 |
77,829,805 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9104:Foxred2
|
UTSW |
15 |
77,836,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Foxred2
|
UTSW |
15 |
77,839,787 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9205:Foxred2
|
UTSW |
15 |
77,836,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9612:Foxred2
|
UTSW |
15 |
77,836,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Foxred2
|
UTSW |
15 |
77,836,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-02-04 |
Incidental Mutation