Incidental Mutation 'IGL01748:Iglon5'
ID153079
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iglon5
Ensembl Gene ENSMUSG00000013367
Gene NameIgLON family member 5
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.092) question?
Stock #IGL01748
Quality Score
Status
Chromosome7
Chromosomal Location43472904-43490075 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to T at 43476529 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000107974] [ENSMUST00000107977]
Predicted Effect probably benign
Transcript: ENSMUST00000107974
SMART Domains Protein: ENSMUSP00000103608
Gene: ENSMUSG00000013367

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 39 130 1.7e-6 SMART
IGc2 145 202 4.45e-10 SMART
IGc2 229 298 1.69e-10 SMART
low complexity region 323 334 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107977
SMART Domains Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 28 52 N/A INTRINSIC
IG 183 285 1.92e0 SMART
IG 298 383 2.15e-3 SMART
IGc2 406 465 4.19e-6 SMART
Blast:IG_like 582 649 1e-13 BLAST
transmembrane domain 764 786 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000206336
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb1 T C 15: 74,548,357 probably benign Het
Asb1 G A 1: 91,552,286 V236I probably damaging Het
Bod1l G A 5: 41,816,961 R2337C probably benign Het
Fermt3 A T 19: 7,003,466 probably null Het
Foxred2 T C 15: 77,952,346 D323G probably damaging Het
Fry A G 5: 150,345,651 probably benign Het
Galnt11 T A 5: 25,247,515 Y8* probably null Het
Gm42688 T A 6: 83,103,020 S275T possibly damaging Het
Grip2 C T 6: 91,764,743 G934R probably damaging Het
Igkv1-122 G T 6: 68,017,472 V115F possibly damaging Het
Nbl1 G T 4: 139,083,610 probably benign Het
Nup107 A G 10: 117,757,274 V833A probably benign Het
Olfr1287 T C 2: 111,449,530 L130P probably damaging Het
Psg18 T C 7: 18,353,551 N61D probably benign Het
Rfng A G 11: 120,783,743 M104T probably benign Het
Scn10a A G 9: 119,627,084 F1224S probably damaging Het
Strn4 C T 7: 16,838,302 P647S probably damaging Het
Tbc1d2 A G 4: 46,616,306 V474A probably damaging Het
Trav13n-4 A T 14: 53,364,013 T80S probably benign Het
Trrap A G 5: 144,833,340 E2757G probably damaging Het
Vmn1r43 G T 6: 89,870,312 T64N probably damaging Het
Vmn2r108 A T 17: 20,463,214 I576N probably benign Het
Vmn2r65 A T 7: 84,940,299 I803N probably damaging Het
Zfp341 T C 2: 154,628,927 V288A probably damaging Het
Other mutations in Iglon5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02373:Iglon5 APN 7 43479219 missense probably benign 0.09
R0219:Iglon5 UTSW 7 43476837 missense probably damaging 1.00
R1381:Iglon5 UTSW 7 43476640 missense probably benign 0.10
R1503:Iglon5 UTSW 7 43479025 missense probably benign 0.05
R1827:Iglon5 UTSW 7 43479121 missense probably benign 0.01
R2233:Iglon5 UTSW 7 43480638 missense probably damaging 0.98
R2234:Iglon5 UTSW 7 43480638 missense probably damaging 0.98
R2235:Iglon5 UTSW 7 43480638 missense probably damaging 0.98
R3772:Iglon5 UTSW 7 43480613 nonsense probably null
R6388:Iglon5 UTSW 7 43478132 missense possibly damaging 0.92
R7000:Iglon5 UTSW 7 43476830 critical splice donor site probably null
R7015:Iglon5 UTSW 7 43476927 missense probably benign 0.00
R7020:Iglon5 UTSW 7 43476895 missense probably damaging 1.00
Posted On2014-02-04