Incidental Mutation 'IGL01751:Obp2b'
ID 153131
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Obp2b
Ensembl Gene ENSMUSG00000079539
Gene Name odorant binding protein 2B
Synonyms Lcn14, OTTMUSG00000012631
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL01751
Quality Score
Status
Chromosome 2
Chromosomal Location 25627021-25630109 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 25627760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 59 (V59L)
Ref Sequence ENSEMBL: ENSMUSP00000109830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114192]
AlphaFold A2BHR0
Predicted Effect possibly damaging
Transcript: ENSMUST00000114192
AA Change: V59L

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000109830
Gene: ENSMUSG00000079539
AA Change: V59L

DomainStartEndE-ValueType
low complexity region 4 17 N/A INTRINSIC
Pfam:Lipocalin 31 169 5.6e-32 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik A G 5: 144,979,981 (GRCm39) probably null Het
Abtb3 C A 10: 85,490,366 (GRCm39) Q1011K probably damaging Het
Aoc1l2 A T 6: 48,907,522 (GRCm39) H174L possibly damaging Het
Auts2 G T 5: 131,501,198 (GRCm39) Q72K probably damaging Het
Ccdc7b A T 8: 129,863,049 (GRCm39) probably benign Het
Frem3 A G 8: 81,342,372 (GRCm39) E1555G probably benign Het
Gm5263 T G 1: 146,296,302 (GRCm39) noncoding transcript Het
Gm5828 A G 1: 16,840,208 (GRCm39) noncoding transcript Het
Gm6605 T C 7: 38,147,630 (GRCm39) noncoding transcript Het
Gvin3 T A 7: 106,201,516 (GRCm39) N576I possibly damaging Het
Hps3 T C 3: 20,065,130 (GRCm39) D638G probably damaging Het
Igdcc4 A T 9: 65,039,014 (GRCm39) N887I probably damaging Het
Itpkc G A 7: 26,912,491 (GRCm39) probably benign Het
Mfge8 A G 7: 78,786,403 (GRCm39) probably null Het
Mrc2 G T 11: 105,216,560 (GRCm39) L116F probably benign Het
Necab1 T C 4: 14,978,171 (GRCm39) D226G probably damaging Het
Neurod2 T C 11: 98,218,201 (GRCm39) E321G possibly damaging Het
Olr1 T C 6: 129,465,811 (GRCm39) N65S possibly damaging Het
Or14c39 A T 7: 86,343,997 (GRCm39) Q111L probably benign Het
Or2n1 G T 17: 38,486,577 (GRCm39) V201L probably benign Het
Or5d43 A T 2: 88,104,977 (GRCm39) C139S possibly damaging Het
Or8b48 C T 9: 38,492,809 (GRCm39) P79S probably damaging Het
Rock1 A G 18: 10,079,113 (GRCm39) probably null Het
Scn3a T A 2: 65,291,596 (GRCm39) M1717L possibly damaging Het
Smg7 T C 1: 152,719,812 (GRCm39) D903G possibly damaging Het
Tlr1 A T 5: 65,083,290 (GRCm39) L429* probably null Het
Ttll9 A T 2: 152,825,025 (GRCm39) N68I probably damaging Het
Ttn A G 2: 76,567,943 (GRCm39) V25904A possibly damaging Het
Uaca G A 9: 60,777,139 (GRCm39) V507M probably damaging Het
Vmn1r195 G T 13: 22,463,421 (GRCm39) C297F probably benign Het
Zdhhc2 G A 8: 40,926,042 (GRCm39) A346T probably benign Het
Other mutations in Obp2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00556:Obp2b APN 2 25,628,593 (GRCm39) missense probably damaging 1.00
IGL01293:Obp2b APN 2 25,627,719 (GRCm39) missense probably benign 0.00
IGL01731:Obp2b APN 2 25,629,293 (GRCm39) missense possibly damaging 0.74
IGL02631:Obp2b APN 2 25,629,255 (GRCm39) missense probably damaging 0.96
R0035:Obp2b UTSW 2 25,628,645 (GRCm39) missense probably damaging 1.00
R0035:Obp2b UTSW 2 25,628,645 (GRCm39) missense probably damaging 1.00
R1753:Obp2b UTSW 2 25,628,652 (GRCm39) critical splice donor site probably null
R1955:Obp2b UTSW 2 25,628,563 (GRCm39) missense probably benign 0.12
R4956:Obp2b UTSW 2 25,627,087 (GRCm39) missense probably damaging 0.96
R5253:Obp2b UTSW 2 25,627,155 (GRCm39) missense probably benign 0.08
R6434:Obp2b UTSW 2 25,628,599 (GRCm39) missense probably damaging 1.00
R7176:Obp2b UTSW 2 25,627,760 (GRCm39) missense possibly damaging 0.89
Z1177:Obp2b UTSW 2 25,627,695 (GRCm39) missense probably benign 0.17
Posted On 2014-02-04