Incidental Mutation 'IGL01751:Obp2b'
ID153131
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Obp2b
Ensembl Gene ENSMUSG00000079539
Gene Nameodorant binding protein 2B
SynonymsLcn14, OTTMUSG00000012631
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.043) question?
Stock #IGL01751
Quality Score
Status
Chromosome2
Chromosomal Location25737009-25740097 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 25737748 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 59 (V59L)
Ref Sequence ENSEMBL: ENSMUSP00000109830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114192]
Predicted Effect possibly damaging
Transcript: ENSMUST00000114192
AA Change: V59L

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000109830
Gene: ENSMUSG00000079539
AA Change: V59L

DomainStartEndE-ValueType
low complexity region 4 17 N/A INTRINSIC
Pfam:Lipocalin 31 169 5.6e-32 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600015I10Rik A T 6: 48,930,588 H174L possibly damaging Het
1700018F24Rik A G 5: 145,043,171 probably null Het
Auts2 G T 5: 131,472,360 Q72K probably damaging Het
Btbd11 C A 10: 85,654,502 Q1011K probably damaging Het
Ccdc7b A T 8: 129,136,568 probably benign Het
Frem3 A G 8: 80,615,743 E1555G probably benign Het
Gm1966 T A 7: 106,602,309 N576I possibly damaging Het
Gm5263 T G 1: 146,420,564 noncoding transcript Het
Gm5828 A G 1: 16,769,984 noncoding transcript Het
Gm6605 T C 7: 38,448,206 noncoding transcript Het
Hps3 T C 3: 20,010,966 D638G probably damaging Het
Igdcc4 A T 9: 65,131,732 N887I probably damaging Het
Itpkc G A 7: 27,213,066 probably benign Het
Mfge8 A G 7: 79,136,655 probably null Het
Mrc2 G T 11: 105,325,734 L116F probably benign Het
Necab1 T C 4: 14,978,171 D226G probably damaging Het
Neurod2 T C 11: 98,327,375 E321G possibly damaging Het
Olfr1173 A T 2: 88,274,633 C139S possibly damaging Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Olfr292 A T 7: 86,694,789 Q111L probably benign Het
Olfr912 C T 9: 38,581,513 P79S probably damaging Het
Olr1 T C 6: 129,488,848 N65S possibly damaging Het
Rock1 A G 18: 10,079,113 probably null Het
Scn3a T A 2: 65,461,252 M1717L possibly damaging Het
Smg7 T C 1: 152,844,061 D903G possibly damaging Het
Tlr1 A T 5: 64,925,947 L429* probably null Het
Ttll9 A T 2: 152,983,105 N68I probably damaging Het
Ttn A G 2: 76,737,599 V25904A possibly damaging Het
Uaca G A 9: 60,869,857 V507M probably damaging Het
Vmn1r195 G T 13: 22,279,251 C297F probably benign Het
Zdhhc2 G A 8: 40,473,001 A346T probably benign Het
Other mutations in Obp2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00556:Obp2b APN 2 25738581 missense probably damaging 1.00
IGL01293:Obp2b APN 2 25737707 missense probably benign 0.00
IGL01731:Obp2b APN 2 25739281 missense possibly damaging 0.74
IGL02631:Obp2b APN 2 25739243 missense probably damaging 0.96
R0035:Obp2b UTSW 2 25738633 missense probably damaging 1.00
R0035:Obp2b UTSW 2 25738633 missense probably damaging 1.00
R1753:Obp2b UTSW 2 25738640 critical splice donor site probably null
R1955:Obp2b UTSW 2 25738551 missense probably benign 0.12
R4956:Obp2b UTSW 2 25737075 missense probably damaging 0.96
R5253:Obp2b UTSW 2 25737143 missense probably benign 0.08
R6434:Obp2b UTSW 2 25738587 missense probably damaging 1.00
Posted On2014-02-04