Incidental Mutation 'IGL01757:Zfp648'
| ID |
153224 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp648
|
| Ensembl Gene |
ENSMUSG00000066797 |
| Gene Name |
zinc finger protein 648 |
| Synonyms |
Gm10178, LOC207678 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.091)
|
| Stock # |
IGL01757
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
154076933-154081435 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 154080671 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 277
(S277P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083370
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086195]
|
| AlphaFold |
D3Z0W3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086195
AA Change: S277P
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: S277P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
236 |
258 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
292 |
315 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
321 |
343 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
349 |
371 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
377 |
399 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
405 |
427 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
433 |
455 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
461 |
483 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
489 |
511 |
1.2e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc6 |
T |
C |
7: 45,639,705 (GRCm39) |
|
probably benign |
Het |
| Adamts9 |
T |
C |
6: 92,773,140 (GRCm39) |
Y1789C |
probably damaging |
Het |
| Cdcp1 |
A |
T |
9: 123,009,066 (GRCm39) |
Y537* |
probably null |
Het |
| Chic2 |
T |
C |
5: 75,167,428 (GRCm39) |
|
probably benign |
Het |
| Cpa5 |
G |
A |
6: 30,625,926 (GRCm39) |
|
probably benign |
Het |
| Csgalnact2 |
T |
C |
6: 118,106,307 (GRCm39) |
R4G |
probably damaging |
Het |
| Dnah10 |
T |
A |
5: 124,845,991 (GRCm39) |
V1510D |
probably benign |
Het |
| Dnm2 |
T |
A |
9: 21,376,915 (GRCm39) |
F91L |
probably damaging |
Het |
| Eif2b1 |
T |
C |
5: 124,711,203 (GRCm39) |
K189E |
probably benign |
Het |
| Fgf17 |
A |
T |
14: 70,874,420 (GRCm39) |
L123Q |
probably damaging |
Het |
| Ifna15 |
T |
C |
4: 88,476,322 (GRCm39) |
K54R |
possibly damaging |
Het |
| Isg15 |
A |
G |
4: 156,284,301 (GRCm39) |
C76R |
probably damaging |
Het |
| Ldb2 |
A |
T |
5: 44,699,209 (GRCm39) |
|
probably benign |
Het |
| Lig4 |
A |
G |
8: 10,021,185 (GRCm39) |
I865T |
probably benign |
Het |
| Lrrc46 |
T |
C |
11: 96,926,701 (GRCm39) |
Y154C |
probably damaging |
Het |
| Lrrc8a |
G |
A |
2: 30,145,537 (GRCm39) |
R117H |
possibly damaging |
Het |
| Mrpl2 |
A |
G |
17: 46,959,183 (GRCm39) |
I96V |
probably damaging |
Het |
| Mtif2 |
G |
A |
11: 29,491,337 (GRCm39) |
|
probably benign |
Het |
| Or2n1 |
G |
T |
17: 38,486,577 (GRCm39) |
V201L |
probably benign |
Het |
| Ptpn23 |
G |
A |
9: 110,220,704 (GRCm39) |
R269W |
probably damaging |
Het |
| Senp2 |
T |
C |
16: 21,828,414 (GRCm39) |
V8A |
probably benign |
Het |
| Slf1 |
T |
C |
13: 77,232,559 (GRCm39) |
D515G |
probably benign |
Het |
| Spc25 |
G |
A |
2: 69,032,952 (GRCm39) |
Q58* |
probably null |
Het |
| Sult2a5 |
T |
C |
7: 13,399,079 (GRCm39) |
S229P |
probably damaging |
Het |
| Tfap2d |
A |
G |
1: 19,174,804 (GRCm39) |
T86A |
probably benign |
Het |
| Trp53bp1 |
A |
G |
2: 121,041,785 (GRCm39) |
V1257A |
probably damaging |
Het |
| Wdr6 |
A |
G |
9: 108,453,427 (GRCm39) |
V152A |
possibly damaging |
Het |
| Zdhhc7 |
A |
G |
8: 120,814,662 (GRCm39) |
V49A |
probably benign |
Het |
|
| Other mutations in Zfp648 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00585:Zfp648
|
APN |
1 |
154,079,935 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01150:Zfp648
|
APN |
1 |
154,081,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01557:Zfp648
|
APN |
1 |
154,080,426 (GRCm39) |
missense |
probably benign |
|
|
IGL02247:Zfp648
|
APN |
1 |
154,079,923 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4519001:Zfp648
|
UTSW |
1 |
154,080,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0001:Zfp648
|
UTSW |
1 |
154,081,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0256:Zfp648
|
UTSW |
1 |
154,081,414 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0266:Zfp648
|
UTSW |
1 |
154,080,632 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0371:Zfp648
|
UTSW |
1 |
154,080,413 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1498:Zfp648
|
UTSW |
1 |
154,081,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Zfp648
|
UTSW |
1 |
154,080,138 (GRCm39) |
missense |
probably benign |
|
|
R1687:Zfp648
|
UTSW |
1 |
154,079,988 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2128:Zfp648
|
UTSW |
1 |
154,080,353 (GRCm39) |
missense |
probably benign |
|
|
R2427:Zfp648
|
UTSW |
1 |
154,080,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Zfp648
|
UTSW |
1 |
154,080,695 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2844:Zfp648
|
UTSW |
1 |
154,080,881 (GRCm39) |
nonsense |
probably null |
|
|
R3711:Zfp648
|
UTSW |
1 |
154,080,304 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4491:Zfp648
|
UTSW |
1 |
154,080,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4693:Zfp648
|
UTSW |
1 |
154,080,152 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5666:Zfp648
|
UTSW |
1 |
154,079,963 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5670:Zfp648
|
UTSW |
1 |
154,079,963 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7432:Zfp648
|
UTSW |
1 |
154,080,783 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8069:Zfp648
|
UTSW |
1 |
154,079,862 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8137:Zfp648
|
UTSW |
1 |
154,081,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8282:Zfp648
|
UTSW |
1 |
154,080,535 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9023:Zfp648
|
UTSW |
1 |
154,080,914 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9489:Zfp648
|
UTSW |
1 |
154,080,110 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9520:Zfp648
|
UTSW |
1 |
154,081,221 (GRCm39) |
missense |
probably benign |
|
|
R9605:Zfp648
|
UTSW |
1 |
154,080,110 (GRCm39) |
missense |
probably benign |
0.17 |
|
Z1088:Zfp648
|
UTSW |
1 |
154,080,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2014-02-04 |
Incidental Mutation