Incidental Mutation 'IGL01761:Mier2'
ID 153593
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mier2
Ensembl Gene ENSMUSG00000042570
Gene Name MIER family member 2
Synonyms 2700087H15Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # IGL01761
Quality Score
Status
Chromosome 10
Chromosomal Location 79376079-79391033 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 79384186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062855] [ENSMUST00000164895] [ENSMUST00000165028] [ENSMUST00000165778] [ENSMUST00000165866] [ENSMUST00000167183] [ENSMUST00000167689] [ENSMUST00000170018]
AlphaFold Q3U3N0
Predicted Effect probably null
Transcript: ENSMUST00000062855
SMART Domains Protein: ENSMUSP00000059864
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 194 246 1.46e-9 SMART
SANT 295 344 6.01e-8 SMART
low complexity region 441 458 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164895
Predicted Effect probably null
Transcript: ENSMUST00000165028
SMART Domains Protein: ENSMUSP00000127387
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
ELM2 196 248 1.46e-9 SMART
SANT 297 346 6.01e-8 SMART
low complexity region 443 460 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165778
Predicted Effect probably benign
Transcript: ENSMUST00000165866
SMART Domains Protein: ENSMUSP00000127332
Gene: ENSMUSG00000042570

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 42 64 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167183
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167760
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170950
Predicted Effect probably benign
Transcript: ENSMUST00000167689
Predicted Effect probably benign
Transcript: ENSMUST00000170018
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410137M14Rik T C 17: 37,289,699 (GRCm39) T44A probably damaging Het
A2ml1 T A 6: 128,523,300 (GRCm39) Q1212L possibly damaging Het
A530064D06Rik T C 17: 48,460,127 (GRCm39) S190G possibly damaging Het
AA986860 A G 1: 130,670,459 (GRCm39) H227R possibly damaging Het
Ace C A 11: 105,870,319 (GRCm39) A826E possibly damaging Het
Amigo3 G A 9: 107,930,601 (GRCm39) G8D possibly damaging Het
Angpt1 A T 15: 42,339,863 (GRCm39) F283I possibly damaging Het
Arhgef5 T C 6: 43,251,538 (GRCm39) L763P probably benign Het
Atr T C 9: 95,833,501 (GRCm39) probably benign Het
C4b T A 17: 34,958,912 (GRCm39) M506L possibly damaging Het
Cdc25a T C 9: 109,720,933 (GRCm39) probably benign Het
Dcaf17 T C 2: 70,886,881 (GRCm39) S57P probably damaging Het
Dph5 T A 3: 115,693,362 (GRCm39) D93E probably damaging Het
Fam169a A G 13: 97,228,426 (GRCm39) E33G possibly damaging Het
Fam193b G A 13: 55,697,070 (GRCm39) T340I probably benign Het
Glod4 T C 11: 76,134,428 (GRCm39) N15D probably benign Het
Hrob T C 11: 102,146,422 (GRCm39) C233R probably benign Het
Inpp5k A G 11: 75,538,503 (GRCm39) E102G possibly damaging Het
Kif27 A T 13: 58,485,459 (GRCm39) D500E probably benign Het
Lmntd1 A G 6: 145,379,448 (GRCm39) I15T possibly damaging Het
Lrp2 C T 2: 69,311,579 (GRCm39) R2633H possibly damaging Het
Lrp4 G A 2: 91,312,326 (GRCm39) probably null Het
Lrrc3b A C 14: 15,358,098 (GRCm38) N169K probably benign Het
Marchf7 T C 2: 60,064,539 (GRCm39) S272P probably benign Het
Myo9b G A 8: 71,801,796 (GRCm39) S1307N probably damaging Het
Or4c115 G T 2: 88,927,888 (GRCm39) P128T probably damaging Het
Or5p69 T G 7: 107,967,525 (GRCm39) V276G probably damaging Het
Phkb A T 8: 86,745,693 (GRCm39) M629L probably benign Het
Rergl C A 6: 139,478,863 (GRCm39) V4F probably damaging Het
Rgs22 A T 15: 36,103,897 (GRCm39) I188N probably damaging Het
Rgs3 G T 4: 62,570,946 (GRCm39) probably benign Het
Rpl4 T A 9: 64,082,221 (GRCm39) V40D probably damaging Het
Sox4 A T 13: 29,136,790 (GRCm39) I72N possibly damaging Het
Syne1 A C 10: 5,355,456 (GRCm39) V375G probably damaging Het
Tfrc G T 16: 32,447,369 (GRCm39) D662Y probably damaging Het
Ubqln5 T C 7: 103,777,634 (GRCm39) R397G possibly damaging Het
Unc13d T C 11: 115,964,695 (GRCm39) D257G probably damaging Het
Vmn1r160 A T 7: 22,570,868 (GRCm39) N74Y probably damaging Het
Vmn1r168 T A 7: 23,241,070 (GRCm39) I309N possibly damaging Het
Vmn1r20 T C 6: 57,408,725 (GRCm39) L17P probably damaging Het
Wdr19 A G 5: 65,373,163 (GRCm39) I142V possibly damaging Het
Zan A T 5: 137,423,859 (GRCm39) I2680N unknown Het
Zbtb20 T C 16: 43,431,024 (GRCm39) F512L possibly damaging Het
Other mutations in Mier2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01412:Mier2 APN 10 79,377,014 (GRCm39) makesense probably null
IGL01845:Mier2 APN 10 79,385,418 (GRCm39) missense possibly damaging 0.69
IGL02336:Mier2 APN 10 79,384,184 (GRCm39) unclassified probably benign
IGL02882:Mier2 APN 10 79,383,555 (GRCm39) missense probably damaging 1.00
IGL02902:Mier2 APN 10 79,385,456 (GRCm39) missense probably damaging 1.00
R0325:Mier2 UTSW 10 79,378,430 (GRCm39) critical splice donor site probably null
R0972:Mier2 UTSW 10 79,380,455 (GRCm39) unclassified probably benign
R1326:Mier2 UTSW 10 79,380,543 (GRCm39) missense probably damaging 1.00
R1333:Mier2 UTSW 10 79,380,991 (GRCm39) missense probably benign 0.03
R1721:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R1867:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R1868:Mier2 UTSW 10 79,384,664 (GRCm39) missense probably damaging 1.00
R2015:Mier2 UTSW 10 79,377,036 (GRCm39) splice site probably null
R2273:Mier2 UTSW 10 79,380,368 (GRCm39) missense probably damaging 1.00
R2274:Mier2 UTSW 10 79,380,368 (GRCm39) missense probably damaging 1.00
R3729:Mier2 UTSW 10 79,380,876 (GRCm39) unclassified probably benign
R3874:Mier2 UTSW 10 79,377,631 (GRCm39) missense possibly damaging 0.49
R3881:Mier2 UTSW 10 79,384,584 (GRCm39) splice site probably null
R4755:Mier2 UTSW 10 79,385,031 (GRCm39) missense probably damaging 1.00
R4758:Mier2 UTSW 10 79,386,182 (GRCm39) missense probably damaging 1.00
R5070:Mier2 UTSW 10 79,385,411 (GRCm39) missense probably benign 0.03
R6282:Mier2 UTSW 10 79,380,576 (GRCm39) missense probably damaging 1.00
R6785:Mier2 UTSW 10 79,380,547 (GRCm39) missense probably damaging 1.00
R6861:Mier2 UTSW 10 79,376,990 (GRCm39) start gained probably benign
R6869:Mier2 UTSW 10 79,378,503 (GRCm39) missense probably damaging 0.99
R6897:Mier2 UTSW 10 79,380,573 (GRCm39) missense probably damaging 0.99
R6902:Mier2 UTSW 10 79,376,673 (GRCm39) utr 3 prime probably benign
R6946:Mier2 UTSW 10 79,376,673 (GRCm39) utr 3 prime probably benign
R6968:Mier2 UTSW 10 79,376,476 (GRCm39) utr 3 prime probably benign
R6971:Mier2 UTSW 10 79,378,263 (GRCm39) missense possibly damaging 0.53
R7072:Mier2 UTSW 10 79,376,133 (GRCm39) missense unknown
R7350:Mier2 UTSW 10 79,376,132 (GRCm39) missense unknown
R7443:Mier2 UTSW 10 79,376,289 (GRCm39) missense unknown
R7506:Mier2 UTSW 10 79,386,176 (GRCm39) missense probably benign 0.14
R7545:Mier2 UTSW 10 79,377,028 (GRCm39) missense possibly damaging 0.79
R7625:Mier2 UTSW 10 79,378,543 (GRCm39) missense probably damaging 1.00
R7669:Mier2 UTSW 10 79,385,510 (GRCm39) missense probably damaging 1.00
R7895:Mier2 UTSW 10 79,377,719 (GRCm39) start gained probably benign
R8494:Mier2 UTSW 10 79,377,546 (GRCm39) missense probably damaging 1.00
R8520:Mier2 UTSW 10 79,378,263 (GRCm39) missense possibly damaging 0.53
R8834:Mier2 UTSW 10 79,386,293 (GRCm39) missense unknown
R8978:Mier2 UTSW 10 79,376,790 (GRCm39) missense unknown
R9005:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9007:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9008:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9018:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9051:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9052:Mier2 UTSW 10 79,384,274 (GRCm39) missense probably damaging 0.99
R9108:Mier2 UTSW 10 79,377,756 (GRCm39) missense probably benign 0.01
R9111:Mier2 UTSW 10 79,381,285 (GRCm39) unclassified probably benign
R9121:Mier2 UTSW 10 79,377,594 (GRCm39) missense
R9281:Mier2 UTSW 10 79,378,294 (GRCm39) missense probably benign 0.06
R9514:Mier2 UTSW 10 79,377,496 (GRCm39) missense probably benign 0.00
Z1176:Mier2 UTSW 10 79,376,335 (GRCm39) missense unknown
Z1177:Mier2 UTSW 10 79,376,295 (GRCm39) missense unknown
Posted On 2014-02-04