Incidental Mutation 'IGL01763:Wdr24'
ID 153606
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr24
Ensembl Gene ENSMUSG00000025737
Gene Name WD repeat domain 24
Synonyms
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01763
Quality Score
Status
Chromosome 17
Chromosomal Location 26042601-26047704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 26045164 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 300 (T300A)
Ref Sequence ENSEMBL: ENSMUSP00000026833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026832] [ENSMUST00000026833] [ENSMUST00000044911] [ENSMUST00000045692] [ENSMUST00000123582] [ENSMUST00000133595]
AlphaFold Q8CFJ9
Predicted Effect probably benign
Transcript: ENSMUST00000026832
SMART Domains Protein: ENSMUSP00000026832
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
JmjC 140 271 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000026833
AA Change: T300A

PolyPhen 2 Score 0.205 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000026833
Gene: ENSMUSG00000025737
AA Change: T300A

DomainStartEndE-ValueType
Blast:WD40 19 53 6e-8 BLAST
WD40 68 103 2.13e1 SMART
WD40 109 149 5.77e-5 SMART
WD40 152 192 4.48e-2 SMART
WD40 196 236 1.48e-11 SMART
WD40 244 282 1.66e0 SMART
WD40 286 327 2.48e0 SMART
low complexity region 605 623 N/A INTRINSIC
Blast:RING 743 780 2e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000044911
SMART Domains Protein: ENSMUSP00000040431
Gene: ENSMUSG00000039615

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
TPR 27 60 2.43e1 SMART
TPR 61 94 1.48e-7 SMART
TPR 95 128 4.52e-3 SMART
low complexity region 168 180 N/A INTRINSIC
Ubox 231 294 1.27e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000045692
SMART Domains Protein: ENSMUSP00000048562
Gene: ENSMUSG00000025738

DomainStartEndE-ValueType
low complexity region 49 65 N/A INTRINSIC
low complexity region 70 89 N/A INTRINSIC
Blast:FBOX 98 137 2e-14 BLAST
LRR 241 266 1.32e1 SMART
LRR 267 291 1.61e2 SMART
LRR 293 318 1.76e2 SMART
LRR 319 344 3.21e-4 SMART
LRR 345 370 7.67e-2 SMART
LRR 371 396 6.13e-1 SMART
LRR 421 446 3.52e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123560
Predicted Effect probably benign
Transcript: ENSMUST00000123582
SMART Domains Protein: ENSMUSP00000119840
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
low complexity region 158 172 N/A INTRINSIC
low complexity region 194 208 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143296
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160829
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123692
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144589
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160275
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160349
Predicted Effect probably benign
Transcript: ENSMUST00000133595
SMART Domains Protein: ENSMUSP00000122744
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
transmembrane domain 55 74 N/A INTRINSIC
JmjC 185 316 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152434
SMART Domains Protein: ENSMUSP00000119378
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer3 C T 7: 97,915,339 (GRCm39) probably benign Het
Atp4a A G 7: 30,414,943 (GRCm39) E244G probably benign Het
Cdh20 T C 1: 109,993,520 (GRCm39) I325T probably benign Het
Dennd2c T C 3: 103,064,224 (GRCm39) L623P probably damaging Het
Eef1akmt3 T C 10: 126,876,952 (GRCm39) D65G probably benign Het
Gimap3 T A 6: 48,742,430 (GRCm39) S167C probably damaging Het
Gm12185 A T 11: 48,806,671 (GRCm39) F173L probably benign Het
Gm5611 A G 9: 16,941,699 (GRCm39) noncoding transcript Het
Gpr161 T C 1: 165,144,820 (GRCm39) S387P probably benign Het
Hsd17b8 A G 17: 34,245,835 (GRCm39) V219A probably damaging Het
Mtfr2 G A 10: 20,228,683 (GRCm39) probably benign Het
Myh8 A G 11: 67,177,245 (GRCm39) K437R probably benign Het
Myo15a A G 11: 60,412,564 (GRCm39) D3335G probably benign Het
Ndufaf7 C T 17: 79,253,771 (GRCm39) T323I possibly damaging Het
Or5g29 A G 2: 85,421,691 (GRCm39) N269S probably benign Het
Pcdh15 T C 10: 74,046,293 (GRCm39) V190A probably benign Het
Pdzd2 A G 15: 12,372,632 (GRCm39) V2501A probably benign Het
Piwil4 A T 9: 14,617,562 (GRCm39) probably null Het
Plxnb2 C T 15: 89,046,184 (GRCm39) probably null Het
Sgcd A G 11: 47,085,856 (GRCm39) probably null Het
Sin3b A G 8: 73,473,236 (GRCm39) K519E probably damaging Het
Slc26a4 C T 12: 31,578,853 (GRCm39) probably benign Het
Spty2d1 T C 7: 46,649,596 (GRCm39) D33G probably damaging Het
Txnrd3 C T 6: 89,638,537 (GRCm39) T242I probably damaging Het
Vps13b A G 15: 35,709,945 (GRCm39) D1964G possibly damaging Het
Zc2hc1c C A 12: 85,336,450 (GRCm39) Q36K probably benign Het
Zfp719 A T 7: 43,233,613 (GRCm39) I11F probably benign Het
Other mutations in Wdr24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Wdr24 APN 17 26,045,595 (GRCm39) missense probably benign 0.20
IGL01700:Wdr24 APN 17 26,044,802 (GRCm39) missense probably damaging 1.00
IGL02567:Wdr24 APN 17 26,043,322 (GRCm39) missense probably damaging 0.99
IGL03100:Wdr24 APN 17 26,044,681 (GRCm39) missense possibly damaging 0.47
R0012:Wdr24 UTSW 17 26,046,087 (GRCm39) missense probably benign
R0799:Wdr24 UTSW 17 26,045,102 (GRCm39) missense probably damaging 1.00
R1015:Wdr24 UTSW 17 26,047,212 (GRCm39) missense probably benign 0.12
R1276:Wdr24 UTSW 17 26,046,441 (GRCm39) missense probably benign 0.02
R1297:Wdr24 UTSW 17 26,046,322 (GRCm39) missense possibly damaging 0.90
R1934:Wdr24 UTSW 17 26,043,240 (GRCm39) missense possibly damaging 0.89
R2030:Wdr24 UTSW 17 26,045,017 (GRCm39) missense probably benign 0.38
R2069:Wdr24 UTSW 17 26,045,256 (GRCm39) missense probably damaging 1.00
R2508:Wdr24 UTSW 17 26,043,273 (GRCm39) missense possibly damaging 0.52
R4601:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R4604:Wdr24 UTSW 17 26,047,479 (GRCm39) missense probably damaging 1.00
R4894:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R5068:Wdr24 UTSW 17 26,044,753 (GRCm39) missense possibly damaging 0.77
R5088:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R5104:Wdr24 UTSW 17 26,043,565 (GRCm39) missense probably damaging 1.00
R5498:Wdr24 UTSW 17 26,043,535 (GRCm39) missense probably damaging 1.00
R5719:Wdr24 UTSW 17 26,047,314 (GRCm39) critical splice donor site probably null
R5892:Wdr24 UTSW 17 26,046,960 (GRCm39) missense probably benign 0.00
R5975:Wdr24 UTSW 17 26,046,102 (GRCm39) missense probably benign 0.37
R6084:Wdr24 UTSW 17 26,043,504 (GRCm39) missense probably damaging 0.99
R6106:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6114:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6116:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6165:Wdr24 UTSW 17 26,045,395 (GRCm39) missense probably benign 0.18
R6175:Wdr24 UTSW 17 26,045,552 (GRCm39) missense probably damaging 1.00
R6331:Wdr24 UTSW 17 26,044,650 (GRCm39) missense possibly damaging 0.61
R6548:Wdr24 UTSW 17 26,046,899 (GRCm39) missense probably damaging 0.99
R6984:Wdr24 UTSW 17 26,047,209 (GRCm39) missense possibly damaging 0.93
R7485:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R7583:Wdr24 UTSW 17 26,044,804 (GRCm39) missense probably null 1.00
R7770:Wdr24 UTSW 17 26,046,070 (GRCm39) missense probably benign 0.04
R8086:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R8164:Wdr24 UTSW 17 26,044,923 (GRCm39) splice site probably null
R9210:Wdr24 UTSW 17 26,043,472 (GRCm39) missense probably benign 0.00
R9212:Wdr24 UTSW 17 26,043,472 (GRCm39) missense probably benign 0.00
R9567:Wdr24 UTSW 17 26,043,190 (GRCm39) missense probably damaging 0.98
R9667:Wdr24 UTSW 17 26,046,301 (GRCm39) missense possibly damaging 0.55
X0022:Wdr24 UTSW 17 26,043,246 (GRCm39) missense probably damaging 0.99
Z1177:Wdr24 UTSW 17 26,044,661 (GRCm39) missense probably benign 0.29
Posted On 2014-02-04