Incidental Mutation 'IGL01764:Polr3g'
ID153626
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Polr3g
Ensembl Gene ENSMUSG00000035834
Gene Namepolymerase (RNA) III (DNA directed) polypeptide G
SynonymsRPC32, 2310047G20Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01764
Quality Score
Status
Chromosome13
Chromosomal Location81673843-81711013 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 81682119 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Methionine at position 145 (T145M)
Ref Sequence ENSEMBL: ENSMUSP00000035289 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048993]
Predicted Effect possibly damaging
Transcript: ENSMUST00000048993
AA Change: T145M

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000035289
Gene: ENSMUSG00000035834
AA Change: T145M

DomainStartEndE-ValueType
Pfam:RNA_pol_3_Rpc31 1 223 7e-41 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162535
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A T 10: 87,074,046 M1L probably benign Het
BC025920 T A 10: 81,609,150 Y36N probably damaging Het
BC030867 T C 11: 102,255,596 C233R probably benign Het
Cdk11b G A 4: 155,628,803 R112H possibly damaging Het
Ctu2 G A 8: 122,479,422 probably benign Het
Ddx56 A C 11: 6,265,692 V219G probably null Het
Dnah14 T C 1: 181,744,777 V2891A probably benign Het
Fbn2 G T 18: 58,045,351 N1938K probably damaging Het
Fbxw20 A G 9: 109,223,359 M302T possibly damaging Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Gm10639 A T 9: 78,304,507 probably null Het
Gpat2 T C 2: 127,427,536 I36T probably benign Het
Hmcn2 A G 2: 31,405,630 E2617G possibly damaging Het
Krba1 C T 6: 48,415,836 R895W probably benign Het
Large2 G T 2: 92,367,186 probably benign Het
Lrp1b C T 2: 40,697,442 V165M unknown Het
Mapk1 T A 16: 16,983,733 M36K possibly damaging Het
Nf1 A G 11: 79,384,187 T25A probably benign Het
Nrxn3 G A 12: 90,204,750 V1316I possibly damaging Het
Pik3r4 G A 9: 105,685,122 probably benign Het
Plekhh1 G T 12: 79,054,905 A250S probably benign Het
Prss32 A G 17: 23,856,111 D145G probably damaging Het
Rab11fip3 T C 17: 26,068,693 K162R probably benign Het
Spag7 A G 11: 70,664,107 probably benign Het
Spata2l T A 8: 123,234,175 Q125L probably benign Het
Tlr9 G T 9: 106,225,805 C765F probably damaging Het
Trip11 A T 12: 101,884,631 I773N probably damaging Het
Vcan T G 13: 89,725,388 T116P probably damaging Het
Vmn2r22 C T 6: 123,650,420 probably null Het
Yme1l1 T C 2: 23,162,544 I70T probably benign Het
Zfp938 T A 10: 82,227,790 probably benign Het
Other mutations in Polr3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Polr3g APN 13 81694677 missense probably damaging 1.00
R0118:Polr3g UTSW 13 81676121 unclassified probably benign
R0550:Polr3g UTSW 13 81694773 missense probably damaging 0.99
R3725:Polr3g UTSW 13 81694635 missense probably damaging 0.99
R6536:Polr3g UTSW 13 81678216 missense unknown
R6684:Polr3g UTSW 13 81699531 intron probably null
Posted On2014-02-04