Incidental Mutation 'IGL00158:Peg3'
| ID |
1537 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Peg3
|
| Ensembl Gene |
ENSMUSG00000002265 |
| Gene Name |
paternally expressed 3 |
| Synonyms |
Zfp102, Gcap4, End4, Pw1 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00158
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
6706891-6733430 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 6713273 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 650
(I650F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000050750
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051209]
[ENSMUST00000143703]
[ENSMUST00000150182]
|
| AlphaFold |
Q3URU2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051209
AA Change: I650F
PolyPhen 2
Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000050750
Gene: ENSMUSG00000002265
AA Change: I650F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
221 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
325 |
347 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
436 |
458 |
2.95e-3 |
SMART |
|
low complexity region
|
464 |
496 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
520 |
542 |
5.99e-4 |
SMART |
|
low complexity region
|
691 |
698 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
850 |
872 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
1091 |
1113 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
1147 |
1169 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
1209 |
1231 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
1266 |
1289 |
1.89e-1 |
SMART |
|
ZnF_C2H2
|
1317 |
1339 |
1.57e2 |
SMART |
|
low complexity region
|
1373 |
1419 |
N/A |
INTRINSIC |
|
low complexity region
|
1440 |
1486 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1488 |
1510 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
1547 |
1569 |
1.38e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143703
|
| SMART Domains |
Protein: ENSMUSP00000122423
Gene: ENSMUSG00000002265
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
19 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150182
|
| SMART Domains |
Protein: ENSMUSP00000116161
Gene: ENSMUSG00000002265
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
19 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
PHENOTYPE: Heterozygous mutant females exhibit growth retardation, impaired maternal behavior and diminished milk ejection, and fewer oxytocin neurons. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Gene trapped(3) |
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd3 |
T |
A |
18: 10,647,869 (GRCm39) |
D300V |
possibly damaging |
Het |
| Agap1 |
A |
G |
1: 89,591,518 (GRCm39) |
|
probably benign |
Het |
| Best3 |
A |
G |
10: 116,840,446 (GRCm39) |
|
probably benign |
Het |
| Cfap43 |
T |
G |
19: 47,818,914 (GRCm39) |
I125L |
probably benign |
Het |
| Cntn1 |
A |
G |
15: 92,148,758 (GRCm39) |
E335G |
possibly damaging |
Het |
| Csmd3 |
A |
T |
15: 48,150,891 (GRCm39) |
S396T |
possibly damaging |
Het |
| Cxxc5 |
T |
G |
18: 35,993,745 (GRCm39) |
*318G |
probably null |
Het |
| Dpep3 |
T |
C |
8: 106,705,779 (GRCm39) |
T49A |
probably benign |
Het |
| Elf1 |
T |
A |
14: 79,817,789 (GRCm39) |
M436K |
possibly damaging |
Het |
| Ephx2 |
T |
G |
14: 66,330,286 (GRCm39) |
I310L |
probably benign |
Het |
| Fancm |
A |
G |
12: 65,122,510 (GRCm39) |
T11A |
possibly damaging |
Het |
| Ganab |
G |
T |
19: 8,879,959 (GRCm39) |
A73S |
probably benign |
Het |
| Glp1r |
T |
G |
17: 31,120,891 (GRCm39) |
L14R |
possibly damaging |
Het |
| Kif14 |
G |
A |
1: 136,396,756 (GRCm39) |
S354N |
probably benign |
Het |
| Krtap9-1 |
C |
T |
11: 99,764,680 (GRCm39) |
P139S |
unknown |
Het |
| L2hgdh |
T |
C |
12: 69,748,208 (GRCm39) |
D306G |
possibly damaging |
Het |
| Liat1 |
T |
C |
11: 75,894,192 (GRCm39) |
S190P |
probably benign |
Het |
| Lrriq4 |
A |
G |
3: 30,705,104 (GRCm39) |
|
probably null |
Het |
| Mbd3 |
T |
G |
10: 80,229,717 (GRCm39) |
|
probably benign |
Het |
| Men1 |
G |
A |
19: 6,387,237 (GRCm39) |
|
probably null |
Het |
| Mug1 |
T |
C |
6: 121,842,768 (GRCm39) |
S585P |
probably damaging |
Het |
| Nat8f4 |
C |
A |
6: 85,877,969 (GRCm39) |
A185S |
probably benign |
Het |
| Nlrc5 |
C |
T |
8: 95,228,839 (GRCm39) |
|
probably benign |
Het |
| Or8b12 |
T |
A |
9: 37,657,685 (GRCm39) |
I85N |
possibly damaging |
Het |
| Or8g23 |
T |
A |
9: 38,971,159 (GRCm39) |
M268L |
probably benign |
Het |
| Prom1 |
A |
T |
5: 44,213,279 (GRCm39) |
N142K |
probably damaging |
Het |
| Qser1 |
T |
A |
2: 104,596,401 (GRCm39) |
D1537V |
probably damaging |
Het |
| Rbm44 |
T |
A |
1: 91,084,831 (GRCm39) |
D684E |
probably benign |
Het |
| Rnf19a |
A |
C |
15: 36,265,948 (GRCm39) |
S50A |
probably damaging |
Het |
| Rnf31 |
A |
G |
14: 55,829,776 (GRCm39) |
|
probably null |
Het |
| Rspry1 |
A |
G |
8: 95,349,614 (GRCm39) |
M1V |
probably null |
Het |
| Rspry1 |
A |
T |
8: 95,349,608 (GRCm39) |
|
probably benign |
Het |
| Sap130 |
C |
A |
18: 31,831,819 (GRCm39) |
P769T |
probably benign |
Het |
| Slc22a16 |
T |
A |
10: 40,471,278 (GRCm39) |
M483K |
probably damaging |
Het |
| Slc27a1 |
T |
C |
8: 72,037,416 (GRCm39) |
|
probably null |
Het |
| Slc35a5 |
A |
T |
16: 44,972,971 (GRCm39) |
C65* |
probably null |
Het |
| Sox4 |
C |
A |
13: 29,136,956 (GRCm39) |
G17W |
probably damaging |
Het |
| Ubqlnl |
T |
C |
7: 103,798,372 (GRCm39) |
E375G |
probably benign |
Het |
| Uggt2 |
G |
A |
14: 119,286,688 (GRCm39) |
T692I |
possibly damaging |
Het |
| Vmn1r211 |
A |
T |
13: 23,036,272 (GRCm39) |
C132S |
probably benign |
Het |
| Vmn2r61 |
A |
T |
7: 41,950,175 (GRCm39) |
N865I |
possibly damaging |
Het |
| Vmn2r73 |
A |
T |
7: 85,506,795 (GRCm39) |
M839K |
|
Het |
| Xrn2 |
T |
A |
2: 146,878,670 (GRCm39) |
S455R |
probably benign |
Het |
| Zan |
T |
A |
5: 137,452,519 (GRCm39) |
T1521S |
unknown |
Het |
| Zfp326 |
A |
G |
5: 106,054,911 (GRCm39) |
M361V |
possibly damaging |
Het |
| Zfp472 |
A |
G |
17: 33,196,498 (GRCm39) |
Y191C |
possibly damaging |
Het |
|
| Other mutations in Peg3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01410:Peg3
|
APN |
7 |
6,710,624 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01415:Peg3
|
APN |
7 |
6,714,652 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02073:Peg3
|
APN |
7 |
6,714,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02193:Peg3
|
APN |
7 |
6,714,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Peg3
|
APN |
7 |
6,714,415 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02215:Peg3
|
APN |
7 |
6,712,010 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02407:Peg3
|
APN |
7 |
6,710,635 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02586:Peg3
|
APN |
7 |
6,713,068 (GRCm39) |
missense |
probably benign |
|
|
IGL02673:Peg3
|
APN |
7 |
6,713,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02935:Peg3
|
APN |
7 |
6,714,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03277:Peg3
|
APN |
7 |
6,714,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03330:Peg3
|
APN |
7 |
6,713,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03393:Peg3
|
APN |
7 |
6,710,648 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0049:Peg3
|
UTSW |
7 |
6,714,672 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0049:Peg3
|
UTSW |
7 |
6,714,672 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0518:Peg3
|
UTSW |
7 |
6,714,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Peg3
|
UTSW |
7 |
6,714,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1477:Peg3
|
UTSW |
7 |
6,719,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1716:Peg3
|
UTSW |
7 |
6,710,780 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1721:Peg3
|
UTSW |
7 |
6,712,900 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1732:Peg3
|
UTSW |
7 |
6,712,084 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2051:Peg3
|
UTSW |
7 |
6,715,720 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2288:Peg3
|
UTSW |
7 |
6,712,114 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3606:Peg3
|
UTSW |
7 |
6,711,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5075:Peg3
|
UTSW |
7 |
6,711,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5076:Peg3
|
UTSW |
7 |
6,711,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5084:Peg3
|
UTSW |
7 |
6,710,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5097:Peg3
|
UTSW |
7 |
6,713,026 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5121:Peg3
|
UTSW |
7 |
6,713,288 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5141:Peg3
|
UTSW |
7 |
6,712,381 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5292:Peg3
|
UTSW |
7 |
6,711,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5294:Peg3
|
UTSW |
7 |
6,720,848 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5342:Peg3
|
UTSW |
7 |
6,712,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5415:Peg3
|
UTSW |
7 |
6,711,628 (GRCm39) |
missense |
probably benign |
|
|
R5906:Peg3
|
UTSW |
7 |
6,720,854 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6056:Peg3
|
UTSW |
7 |
6,712,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Peg3
|
UTSW |
7 |
6,712,810 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6529:Peg3
|
UTSW |
7 |
6,711,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6631:Peg3
|
UTSW |
7 |
6,712,069 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6855:Peg3
|
UTSW |
7 |
6,711,797 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6861:Peg3
|
UTSW |
7 |
6,714,385 (GRCm39) |
nonsense |
probably null |
|
|
R6864:Peg3
|
UTSW |
7 |
6,715,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6892:Peg3
|
UTSW |
7 |
6,711,898 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7018:Peg3
|
UTSW |
7 |
6,711,838 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7039:Peg3
|
UTSW |
7 |
6,720,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7066:Peg3
|
UTSW |
7 |
6,711,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7117:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
R7133:Peg3
|
UTSW |
7 |
6,711,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7493:Peg3
|
UTSW |
7 |
6,712,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Peg3
|
UTSW |
7 |
6,711,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7642:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
R7646:Peg3
|
UTSW |
7 |
6,712,221 (GRCm39) |
missense |
probably benign |
|
|
R7658:Peg3
|
UTSW |
7 |
6,712,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Peg3
|
UTSW |
7 |
6,713,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Peg3
|
UTSW |
7 |
6,711,839 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7903:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
R7913:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
R7948:Peg3
|
UTSW |
7 |
6,711,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Peg3
|
UTSW |
7 |
6,711,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8385:Peg3
|
UTSW |
7 |
6,711,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8672:Peg3
|
UTSW |
7 |
6,711,523 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9133:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
R9209:Peg3
|
UTSW |
7 |
6,711,226 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9457:Peg3
|
UTSW |
7 |
6,710,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9518:Peg3
|
UTSW |
7 |
6,714,280 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9519:Peg3
|
UTSW |
7 |
6,714,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Peg3
|
UTSW |
7 |
6,714,723 (GRCm39) |
missense |
probably damaging |
0.97 |
|
RF039:Peg3
|
UTSW |
7 |
6,712,167 (GRCm39) |
unclassified |
probably benign |
|
|
YA93:Peg3
|
UTSW |
7 |
6,714,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2011-07-12 |
Incidental Mutation