Incidental Mutation 'IGL01778:Reg3g'
ID 153752
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Reg3g
Ensembl Gene ENSMUSG00000030017
Gene Name regenerating islet-derived 3 gamma
Synonyms RegIII (gamma)
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01778
Quality Score
Status
Chromosome 6
Chromosomal Location 78443252-78445855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78443816 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 131 (I131F)
Ref Sequence ENSEMBL: ENSMUSP00000032089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032089]
AlphaFold O09049
Predicted Effect probably benign
Transcript: ENSMUST00000032089
AA Change: I131F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000032089
Gene: ENSMUSG00000030017
AA Change: I131F

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
CLECT 40 171 1.79e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176650
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt2 T C 4: 154,751,162 (GRCm39) K325E probably benign Het
Arc C T 15: 74,544,204 (GRCm39) M6I probably benign Het
Atp7b A T 8: 22,484,844 (GRCm39) D1404E probably benign Het
Cdk5rap1 T A 2: 154,207,956 (GRCm39) N156I probably damaging Het
Ctsa T C 2: 164,676,230 (GRCm39) probably benign Het
Depdc1b T G 13: 108,498,861 (GRCm39) N181K probably benign Het
Epg5 T C 18: 78,062,489 (GRCm39) V1994A probably damaging Het
Epyc T A 10: 97,517,099 (GRCm39) C312* probably null Het
Erv3 T A 2: 131,697,877 (GRCm39) R161* probably null Het
Fhdc1 G A 3: 84,352,042 (GRCm39) A1061V possibly damaging Het
Gfra3 T C 18: 34,824,644 (GRCm39) T280A possibly damaging Het
Gldn A T 9: 54,241,776 (GRCm39) probably null Het
Gtf3c4 G A 2: 28,725,100 (GRCm39) R211C probably damaging Het
Hrob T C 11: 102,146,422 (GRCm39) C233R probably benign Het
Hsh2d A G 8: 72,947,351 (GRCm39) D16G probably damaging Het
Klk15 T A 7: 43,588,262 (GRCm39) M190K probably damaging Het
Klri1 A G 6: 129,694,010 (GRCm39) S26P possibly damaging Het
Krt78 T A 15: 101,859,402 (GRCm39) D265V probably damaging Het
Lgr5 A C 10: 115,298,607 (GRCm39) I355S probably damaging Het
Lig3 T A 11: 82,685,367 (GRCm39) V595D probably damaging Het
Map2k6 A C 11: 110,403,695 (GRCm39) probably benign Het
Mdm4 A G 1: 132,922,285 (GRCm39) S286P probably benign Het
Ncoa4-ps T C 12: 119,226,231 (GRCm39) noncoding transcript Het
Or2ak7 A G 11: 58,575,095 (GRCm39) Y132C probably damaging Het
Pofut1 T A 2: 153,090,448 (GRCm39) M114K probably damaging Het
Rdh13 C T 7: 4,433,388 (GRCm39) probably null Het
Slc26a4 C T 12: 31,578,853 (GRCm39) probably benign Het
Slc8a2 T A 7: 15,892,818 (GRCm39) F827I probably damaging Het
Slfn9 A T 11: 82,878,200 (GRCm39) C310S probably damaging Het
Sypl1 A G 12: 33,025,641 (GRCm39) Y235C probably damaging Het
Trav7-4 A T 14: 53,699,098 (GRCm39) T82S possibly damaging Het
Trim28 T A 7: 12,764,629 (GRCm39) V782D probably damaging Het
Ttn G A 2: 76,575,242 (GRCm39) T25217M probably damaging Het
Usp6nl A G 2: 6,432,381 (GRCm39) T260A possibly damaging Het
Vmn2r54 A T 7: 12,366,009 (GRCm39) N308K probably benign Het
Xdh T C 17: 74,207,275 (GRCm39) E986G probably benign Het
Zfp770 T C 2: 114,026,719 (GRCm39) D450G probably damaging Het
Zw10 T G 9: 48,980,915 (GRCm39) S438R probably benign Het
Other mutations in Reg3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Reg3g APN 6 78,443,762 (GRCm39) missense probably benign
R0389:Reg3g UTSW 6 78,445,544 (GRCm39) start codon destroyed probably null 1.00
R0513:Reg3g UTSW 6 78,444,827 (GRCm39) nonsense probably null
R0562:Reg3g UTSW 6 78,444,471 (GRCm39) missense possibly damaging 0.91
R1872:Reg3g UTSW 6 78,444,836 (GRCm39) nonsense probably null
R2402:Reg3g UTSW 6 78,444,475 (GRCm39) missense probably damaging 1.00
R4896:Reg3g UTSW 6 78,444,793 (GRCm39) missense probably benign
R5113:Reg3g UTSW 6 78,443,544 (GRCm39) splice site probably null
R7352:Reg3g UTSW 6 78,443,842 (GRCm39) nonsense probably null
R8880:Reg3g UTSW 6 78,444,788 (GRCm39) missense probably benign 0.14
R9698:Reg3g UTSW 6 78,444,805 (GRCm39) missense probably benign 0.32
Posted On 2014-02-04