Incidental Mutation 'IGL01778:Zfp770'
ID153761
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp770
Ensembl Gene ENSMUSG00000040321
Gene Namezinc finger protein 770
Synonyms6430601A21Rik
Accession Numbers

Ncbi RefSeq: NM_175466.4; MGI: 2445100

Is this an essential gene? Probably non essential (E-score: 0.192) question?
Stock #IGL01778
Quality Score
Status
Chromosome2
Chromosomal Location114193461-114201469 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 114196238 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 450 (D450G)
Ref Sequence ENSEMBL: ENSMUSP00000052194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050668]
Predicted Effect probably damaging
Transcript: ENSMUST00000050668
AA Change: D450G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: D450G

DomainStartEndE-ValueType
ZnF_C2H2 31 53 1.18e-2 SMART
ZnF_C2H2 59 81 4.11e-2 SMART
ZnF_C2H2 85 107 3.58e-2 SMART
ZnF_C2H2 164 186 2.09e-3 SMART
ZnF_C2H2 192 214 3.58e-2 SMART
ZnF_C2H2 220 242 3.29e-1 SMART
ZnF_C2H2 298 318 1.93e2 SMART
low complexity region 341 354 N/A INTRINSIC
ZnF_C2H2 485 507 5.9e-3 SMART
ZnF_C2H2 513 535 1.82e-3 SMART
low complexity region 576 595 N/A INTRINSIC
ZnF_C2H2 640 662 9.58e-3 SMART
ZnF_C2H2 668 690 7.37e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123562
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt2 T C 4: 154,666,705 K325E probably benign Het
Arc C T 15: 74,672,355 M6I probably benign Het
Atp7b A T 8: 21,994,828 D1404E probably benign Het
BC030867 T C 11: 102,255,596 C233R probably benign Het
Cdk5rap1 T A 2: 154,366,036 N156I probably damaging Het
Ctsa T C 2: 164,834,310 probably benign Het
Depdc1b T G 13: 108,362,327 N181K probably benign Het
Epg5 T C 18: 78,019,274 V1994A probably damaging Het
Epyc T A 10: 97,681,237 C312* probably null Het
Erv3 T A 2: 131,855,957 R161* probably null Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Gfra3 T C 18: 34,691,591 T280A possibly damaging Het
Gldn A T 9: 54,334,492 probably null Het
Gm6768 T C 12: 119,262,496 noncoding transcript Het
Gtf3c4 G A 2: 28,835,088 R211C probably damaging Het
Hsh2d A G 8: 72,193,507 D16G probably damaging Het
Klk15 T A 7: 43,938,838 M190K probably damaging Het
Klri1 A G 6: 129,717,047 S26P possibly damaging Het
Krt78 T A 15: 101,950,967 D265V probably damaging Het
Lgr5 A C 10: 115,462,702 I355S probably damaging Het
Lig3 T A 11: 82,794,541 V595D probably damaging Het
Map2k6 A C 11: 110,512,869 probably benign Het
Mdm4 A G 1: 132,994,547 S286P probably benign Het
Olfr320 A G 11: 58,684,269 Y132C probably damaging Het
Pofut1 T A 2: 153,248,528 M114K probably damaging Het
Rdh13 C T 7: 4,430,389 probably null Het
Reg3g T A 6: 78,466,833 I131F probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc8a2 T A 7: 16,158,893 F827I probably damaging Het
Slfn9 A T 11: 82,987,374 C310S probably damaging Het
Sypl A G 12: 32,975,642 Y235C probably damaging Het
Trav7-4 A T 14: 53,461,641 T82S possibly damaging Het
Trim28 T A 7: 13,030,702 V782D probably damaging Het
Ttn G A 2: 76,744,898 T25217M probably damaging Het
Usp6nl A G 2: 6,427,570 T260A possibly damaging Het
Vmn2r54 A T 7: 12,632,082 N308K probably benign Het
Xdh T C 17: 73,900,280 E986G probably benign Het
Zw10 T G 9: 49,069,615 S438R probably benign Het
Other mutations in Zfp770
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Zfp770 APN 2 114195932 missense probably benign 0.20
IGL00478:Zfp770 APN 2 114197465 missense probably damaging 1.00
IGL01539:Zfp770 APN 2 114197093 missense probably damaging 0.99
IGL02596:Zfp770 APN 2 114195827 missense probably benign 0.11
IGL03227:Zfp770 APN 2 114197089 nonsense probably null
R0057:Zfp770 UTSW 2 114197232 nonsense probably null
R0057:Zfp770 UTSW 2 114197232 nonsense probably null
R1081:Zfp770 UTSW 2 114197127 missense probably damaging 1.00
R1446:Zfp770 UTSW 2 114197033 missense probably damaging 0.99
R4477:Zfp770 UTSW 2 114196884 missense probably damaging 1.00
R4597:Zfp770 UTSW 2 114196770 missense possibly damaging 0.46
R4964:Zfp770 UTSW 2 114197387 missense probably benign 0.24
R4966:Zfp770 UTSW 2 114197387 missense probably benign 0.24
R5259:Zfp770 UTSW 2 114197193 missense probably benign 0.00
R5440:Zfp770 UTSW 2 114196115 missense probably benign 0.42
R5910:Zfp770 UTSW 2 114196232 nonsense probably null
R5941:Zfp770 UTSW 2 114197546 missense possibly damaging 0.83
R6074:Zfp770 UTSW 2 114196389 missense possibly damaging 0.68
R6341:Zfp770 UTSW 2 114196759 missense probably benign 0.14
Posted On2014-02-04