Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01778:Zfp770'

153761

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp770

Ensembl Gene

ENSMUSG00000040321

Gene Name

zinc finger protein 770

Synonyms

6430601A21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.230) question?

Stock #

IGL01778

Quality Score

Status

Chromosome

Chromosomal Location

114023937-114031945 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 114026719 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 450 (D450G)

Ref Sequence

ENSEMBL: ENSMUSP00000052194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050668]

AlphaFold

Q8BIQ8

Predicted Effect

probably damaging
Transcript: ENSMUST00000050668
AA Change: D450G

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: D450G

Domain	Start	End	E-Value	Type
ZnF_C2H2	31	53	1.18e-2	SMART
ZnF_C2H2	59	81	4.11e-2	SMART
ZnF_C2H2	85	107	3.58e-2	SMART
ZnF_C2H2	164	186	2.09e-3	SMART
ZnF_C2H2	192	214	3.58e-2	SMART
ZnF_C2H2	220	242	3.29e-1	SMART
ZnF_C2H2	298	318	1.93e2	SMART
low complexity region	341	354	N/A	INTRINSIC
ZnF_C2H2	485	507	5.9e-3	SMART
ZnF_C2H2	513	535	1.82e-3	SMART
low complexity region	576	595	N/A	INTRINSIC
ZnF_C2H2	640	662	9.58e-3	SMART
ZnF_C2H2	668	690	7.37e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123562

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actrt2	T	C	4: 154,751,162 (GRCm39)	K325E	probably benign	Het
Arc	C	T	15: 74,544,204 (GRCm39)	M6I	probably benign	Het
Atp7b	A	T	8: 22,484,844 (GRCm39)	D1404E	probably benign	Het
Cdk5rap1	T	A	2: 154,207,956 (GRCm39)	N156I	probably damaging	Het
Ctsa	T	C	2: 164,676,230 (GRCm39)		probably benign	Het
Depdc1b	T	G	13: 108,498,861 (GRCm39)	N181K	probably benign	Het
Epg5	T	C	18: 78,062,489 (GRCm39)	V1994A	probably damaging	Het
Epyc	T	A	10: 97,517,099 (GRCm39)	C312*	probably null	Het
Erv3	T	A	2: 131,697,877 (GRCm39)	R161*	probably null	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Gfra3	T	C	18: 34,824,644 (GRCm39)	T280A	possibly damaging	Het
Gldn	A	T	9: 54,241,776 (GRCm39)		probably null	Het
Gtf3c4	G	A	2: 28,725,100 (GRCm39)	R211C	probably damaging	Het
Hrob	T	C	11: 102,146,422 (GRCm39)	C233R	probably benign	Het
Hsh2d	A	G	8: 72,947,351 (GRCm39)	D16G	probably damaging	Het
Klk15	T	A	7: 43,588,262 (GRCm39)	M190K	probably damaging	Het
Klri1	A	G	6: 129,694,010 (GRCm39)	S26P	possibly damaging	Het
Krt78	T	A	15: 101,859,402 (GRCm39)	D265V	probably damaging	Het
Lgr5	A	C	10: 115,298,607 (GRCm39)	I355S	probably damaging	Het
Lig3	T	A	11: 82,685,367 (GRCm39)	V595D	probably damaging	Het
Map2k6	A	C	11: 110,403,695 (GRCm39)		probably benign	Het
Mdm4	A	G	1: 132,922,285 (GRCm39)	S286P	probably benign	Het
Ncoa4-ps	T	C	12: 119,226,231 (GRCm39)		noncoding transcript	Het
Or2ak7	A	G	11: 58,575,095 (GRCm39)	Y132C	probably damaging	Het
Pofut1	T	A	2: 153,090,448 (GRCm39)	M114K	probably damaging	Het
Rdh13	C	T	7: 4,433,388 (GRCm39)		probably null	Het
Reg3g	T	A	6: 78,443,816 (GRCm39)	I131F	probably benign	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc8a2	T	A	7: 15,892,818 (GRCm39)	F827I	probably damaging	Het
Slfn9	A	T	11: 82,878,200 (GRCm39)	C310S	probably damaging	Het
Sypl1	A	G	12: 33,025,641 (GRCm39)	Y235C	probably damaging	Het
Trav7-4	A	T	14: 53,699,098 (GRCm39)	T82S	possibly damaging	Het
Trim28	T	A	7: 12,764,629 (GRCm39)	V782D	probably damaging	Het
Ttn	G	A	2: 76,575,242 (GRCm39)	T25217M	probably damaging	Het
Usp6nl	A	G	2: 6,432,381 (GRCm39)	T260A	possibly damaging	Het
Vmn2r54	A	T	7: 12,366,009 (GRCm39)	N308K	probably benign	Het
Xdh	T	C	17: 74,207,275 (GRCm39)	E986G	probably benign	Het
Zw10	T	G	9: 48,980,915 (GRCm39)	S438R	probably benign	Het

Other mutations in Zfp770

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Zfp770	APN	2	114,026,413 (GRCm39)	missense	probably benign	0.20
IGL00478:Zfp770	APN	2	114,027,946 (GRCm39)	missense	probably damaging	1.00
IGL01539:Zfp770	APN	2	114,027,574 (GRCm39)	missense	probably damaging	0.99
IGL02596:Zfp770	APN	2	114,026,308 (GRCm39)	missense	probably benign	0.11
IGL03227:Zfp770	APN	2	114,027,570 (GRCm39)	nonsense	probably null
R0057:Zfp770	UTSW	2	114,027,713 (GRCm39)	nonsense	probably null
R0057:Zfp770	UTSW	2	114,027,713 (GRCm39)	nonsense	probably null
R1081:Zfp770	UTSW	2	114,027,608 (GRCm39)	missense	probably damaging	1.00
R1446:Zfp770	UTSW	2	114,027,514 (GRCm39)	missense	probably damaging	0.99
R4477:Zfp770	UTSW	2	114,027,365 (GRCm39)	missense	probably damaging	1.00
R4597:Zfp770	UTSW	2	114,027,251 (GRCm39)	missense	possibly damaging	0.46
R4964:Zfp770	UTSW	2	114,027,868 (GRCm39)	missense	probably benign	0.24
R4966:Zfp770	UTSW	2	114,027,868 (GRCm39)	missense	probably benign	0.24
R5259:Zfp770	UTSW	2	114,027,674 (GRCm39)	missense	probably benign	0.00
R5440:Zfp770	UTSW	2	114,026,596 (GRCm39)	missense	probably benign	0.42
R5910:Zfp770	UTSW	2	114,026,713 (GRCm39)	nonsense	probably null
R5941:Zfp770	UTSW	2	114,028,027 (GRCm39)	missense	possibly damaging	0.83
R6074:Zfp770	UTSW	2	114,026,870 (GRCm39)	missense	possibly damaging	0.68
R6341:Zfp770	UTSW	2	114,027,240 (GRCm39)	missense	probably benign	0.14
R7181:Zfp770	UTSW	2	114,027,872 (GRCm39)	missense	probably damaging	1.00
R7288:Zfp770	UTSW	2	114,026,142 (GRCm39)	nonsense	probably null
R7935:Zfp770	UTSW	2	114,027,305 (GRCm39)	missense	probably benign	0.00
R8119:Zfp770	UTSW	2	114,027,508 (GRCm39)	missense	probably damaging	1.00
R8304:Zfp770	UTSW	2	114,027,891 (GRCm39)	missense	probably damaging	1.00
R9356:Zfp770	UTSW	2	114,026,917 (GRCm39)	missense	possibly damaging	0.83
R9657:Zfp770	UTSW	2	114,027,766 (GRCm39)	missense	probably damaging	0.97
R9663:Zfp770	UTSW	2	114,026,949 (GRCm39)	missense	probably benign	0.01

Posted On

2014-02-04