Incidental Mutation 'IGL00164:Tmem190'
ID1540
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem190
Ensembl Gene ENSMUSG00000013091
Gene Nametransmembrane protein 190
Synonyms4930572D21Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00164
Quality Score
Status
Chromosome7
Chromosomal Location4782937-4784341 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 4782999 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000013235] [ENSMUST00000094892] [ENSMUST00000163481] [ENSMUST00000168578]
Predicted Effect unknown
Transcript: ENSMUST00000013235
AA Change: I6T
SMART Domains Protein: ENSMUSP00000013235
Gene: ENSMUSG00000013091
AA Change: I6T

DomainStartEndE-ValueType
low complexity region 3 18 N/A INTRINSIC
Pfam:TMEM190 21 147 3.3e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094892
SMART Domains Protein: ENSMUSP00000092492
Gene: ENSMUSG00000004371

DomainStartEndE-ValueType
Pfam:IL11 1 199 1.3e-119 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163481
SMART Domains Protein: ENSMUSP00000131168
Gene: ENSMUSG00000004371

DomainStartEndE-ValueType
Pfam:IL11 1 140 2.1e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168578
SMART Domains Protein: ENSMUSP00000130452
Gene: ENSMUSG00000030431

DomainStartEndE-ValueType
Pfam:TMEM238 32 100 1.2e-32 PFAM
low complexity region 124 135 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000206315
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206395
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele are viable and fertile with no gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T A 13: 77,323,358 probably benign Het
Abcg4 A G 9: 44,275,142 probably benign Het
Actr2 A G 11: 20,080,015 probably benign Het
Adgrb3 A G 1: 25,228,500 L843P probably benign Het
Cdk19 G A 10: 40,436,165 D137N probably benign Het
Cuedc2 T A 19: 46,331,920 I71F probably damaging Het
Dag1 A G 9: 108,209,288 V218A probably damaging Het
Dlg5 A C 14: 24,158,464 S868R possibly damaging Het
Ecsit C T 9: 22,073,014 G340D probably benign Het
Fkbp8 A G 8: 70,534,561 M358V probably damaging Het
Gckr G A 5: 31,299,576 V79M probably damaging Het
Gpd1 C A 15: 99,720,651 D172E probably benign Het
Josd2 T C 7: 44,471,316 probably benign Het
Kcna2 T C 3: 107,104,630 S176P probably damaging Het
Kcnq4 G A 4: 120,698,016 Q657* probably null Het
Kif14 G A 1: 136,469,018 S354N probably benign Het
Notch1 G A 2: 26,460,046 R2361W probably damaging Het
Olfr1134 T C 2: 87,656,238 M228V probably benign Het
Palb2 A C 7: 122,121,048 probably benign Het
Pan2 C T 10: 128,312,926 Q452* probably null Het
Pcnx T C 12: 81,895,101 V91A probably damaging Het
Rgs22 T A 15: 36,099,931 I213F possibly damaging Het
Serpina3b G T 12: 104,138,787 W407C probably benign Het
Sf3b2 T C 19: 5,279,587 D687G probably benign Het
Slc8a3 T C 12: 81,314,569 E492G probably benign Het
Sox4 C A 13: 28,952,973 G17W probably damaging Het
Sp2 C T 11: 96,954,561 R578H probably damaging Het
Surf1 C T 2: 26,913,572 probably null Het
Zfhx2 A G 14: 55,065,026 S1834P possibly damaging Het
Zfp607a G A 7: 27,877,789 E95K possibly damaging Het
Other mutations in Tmem190
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Tmem190 APN 7 4784026 unclassified probably benign
IGL02667:Tmem190 APN 7 4783158 missense probably benign 0.06
R1647:Tmem190 UTSW 7 4784121 missense probably damaging 1.00
R1717:Tmem190 UTSW 7 4784133 missense probably damaging 0.98
R5712:Tmem190 UTSW 7 4784289 missense probably damaging 1.00
R7132:Tmem190 UTSW 7 4784225 missense not run
Posted On2011-07-12