Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01768:Oprm1'

154002

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oprm1

Ensembl Gene

ENSMUSG00000000766

Gene Name

opioid receptor, mu 1

Synonyms

MOP-R, MOR-1, MOP receptor, mor, Oprm, muOR

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL01768

Quality Score

Status

Chromosome

Chromosomal Location

6708593-6988209 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 6779186 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 196 (S196P)

Ref Sequence

ENSEMBL: ENSMUSP00000114342 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000783] [ENSMUST00000052751] [ENSMUST00000056385] [ENSMUST00000063036] [ENSMUST00000078634] [ENSMUST00000092729] [ENSMUST00000092731] [ENSMUST00000105604] [ENSMUST00000105611] [ENSMUST00000092734] [ENSMUST00000105607] [ENSMUST00000129221] [ENSMUST00000105602] [ENSMUST00000105605] [ENSMUST00000129954] [ENSMUST00000105603] [ENSMUST00000105615] [ENSMUST00000123861] [ENSMUST00000105601] [ENSMUST00000105597] [ENSMUST00000144264] [ENSMUST00000135502] [ENSMUST00000154941] [ENSMUST00000154906] [ENSMUST00000147171] [ENSMUST00000152674] [ENSMUST00000150374] [ENSMUST00000143875]

AlphaFold

P42866

Predicted Effect

probably damaging
Transcript: ENSMUST00000000783
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000000783
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	1.6e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.3e-10	PFAM
Pfam:7tm_1	85	336	4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000052751
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000056385
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000060590
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000063036
AA Change: S128P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
AA Change: S128P

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	8.7e-64	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000078634
AA Change: S196P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000077704
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	2.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	2.4e-10	PFAM
Pfam:7tm_1	85	336	9e-60	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092729
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000090405
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.6e-11	PFAM
Pfam:7tm_1	85	336	3.1e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092731
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000090407
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.9e-11	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105604
AA Change: S196P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101229
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	332	5.1e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.9e-11	PFAM
Pfam:7tm_1	85	336	3.8e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105611
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	338	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.4e-10	PFAM
Pfam:7tm_1	85	336	4.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092734
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000090410
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105607
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101232
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000129221
AA Change: S132P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
AA Change: S132P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	12	261	1.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	15	287	7.3e-11	PFAM
Pfam:7tm_1	21	272	2.4e-67	PFAM
low complexity region	340	351	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000105602
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101227
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.8e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.8e-11	PFAM
Pfam:7tm_1	85	336	3.1e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105605
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101230
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.8e-11	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000129954
AA Change: S196P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	338	6.9e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.5e-10	PFAM
Pfam:7tm_1	85	336	5.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105603
AA Change: S196P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101228
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	6.7e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.6e-11	PFAM
Pfam:7tm_1	85	336	3.6e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105615
AA Change: S128P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
AA Change: S128P

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	1.3e-63	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133486

Predicted Effect

probably benign
Transcript: ENSMUST00000123861

SMART Domains

Protein: ENSMUSP00000120187
Gene: ENSMUSG00000000766

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	100	3e-9	SMART
PDB:4DKL\|A	52	100	3e-21	PDB
low complexity region	119	131	N/A	INTRINSIC
low complexity region	173	184	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105601

SMART Domains

Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	100	3e-9	SMART
PDB:4DKL\|A	52	100	3e-21	PDB
low complexity region	119	131	N/A	INTRINSIC
low complexity region	173	184	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105597

Predicted Effect

probably damaging
Transcript: ENSMUST00000144264
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000135502
AA Change: S196P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000135143
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	2.2e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.9e-10	PFAM
Pfam:7tm_1	85	336	7.5e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000154941
AA Change: S132P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
AA Change: S132P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	12	261	9.6e-8	PFAM
Pfam:7TM_GPCR_Srsx	15	287	6.1e-11	PFAM
Pfam:7tm_1	21	272	2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000154906
AA Change: S196P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000114342
Gene: ENSMUSG00000000766
AA Change: S196P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	332	1.5e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.1e-10	PFAM
Pfam:7tm_1	85	336	3.6e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000147171
AA Change: S128P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000117950
Gene: ENSMUSG00000000766
AA Change: S128P

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	9.2e-64	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148625

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141897

Predicted Effect

probably benign
Transcript: ENSMUST00000152674

SMART Domains

Protein: ENSMUSP00000115552
Gene: ENSMUSG00000000766

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	94	8e-8	SMART
PDB:4DKL\|A	52	94	7e-23	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000150374

Predicted Effect

probably benign
Transcript: ENSMUST00000143875

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aifm3	T	C	16: 17,324,141 (GRCm39)	V567A	possibly damaging	Het
Arnt	T	C	3: 95,398,327 (GRCm39)		probably benign	Het
C8b	G	A	4: 104,644,151 (GRCm39)	E273K	probably benign	Het
Capn5	C	T	7: 97,774,480 (GRCm39)	R570H	probably damaging	Het
Cdh9	A	T	15: 16,778,311 (GRCm39)	D42V	possibly damaging	Het
Cdk17	T	C	10: 93,044,123 (GRCm39)	S21P	probably damaging	Het
Cdkl3	T	A	11: 51,916,744 (GRCm39)	F291I	probably damaging	Het
Cfap210	A	T	2: 69,612,471 (GRCm39)		probably benign	Het
Clmn	T	C	12: 104,747,978 (GRCm39)	E523G	probably damaging	Het
Cyp4f14	A	T	17: 33,126,976 (GRCm39)	I318N	probably damaging	Het
Daam1	T	A	12: 72,036,659 (GRCm39)	F1068L	probably benign	Het
Ext2	A	G	2: 93,621,455 (GRCm39)		probably benign	Het
F5	T	A	1: 164,003,914 (GRCm39)	F236L	probably benign	Het
Fat2	A	G	11: 55,153,394 (GRCm39)	V3606A	probably damaging	Het
Gpam	G	A	19: 55,075,952 (GRCm39)	T220M	probably benign	Het
Hyal1	C	A	9: 107,456,338 (GRCm39)	L342I	probably damaging	Het
Ilvbl	C	A	10: 78,419,127 (GRCm39)	P459T	possibly damaging	Het
Itga5	A	G	15: 103,259,997 (GRCm39)	Y632H	probably benign	Het
Jkampl	A	T	6: 73,445,899 (GRCm39)	L217M	possibly damaging	Het
Krt73	T	C	15: 101,707,291 (GRCm39)	D299G	probably benign	Het
Lcp1	T	C	14: 75,461,573 (GRCm39)	V522A	probably benign	Het
Lmo3	A	G	6: 138,393,495 (GRCm39)	C53R	probably damaging	Het
Nsun7	T	C	5: 66,436,043 (GRCm39)	V305A	probably benign	Het
Or2y1e	G	A	11: 49,218,958 (GRCm39)	C240Y	probably damaging	Het
Or4z4	A	T	19: 12,076,403 (GRCm39)	I200N	probably damaging	Het
Or7e168	G	A	9: 19,720,456 (GRCm39)	V281M	possibly damaging	Het
Ovgp1	T	C	3: 105,888,667 (GRCm39)		probably null	Het
Pcdhb20	T	C	18: 37,639,768 (GRCm39)	F765L	possibly damaging	Het
Ppp4r4	T	C	12: 103,547,664 (GRCm39)	V3A	probably benign	Het
Ruvbl1	A	G	6: 88,474,253 (GRCm39)	I419V	probably benign	Het
Scara5	T	A	14: 65,927,224 (GRCm39)	C40*	probably null	Het
Siglec1	T	C	2: 130,916,314 (GRCm39)	Q1212R	probably benign	Het
Slc31a1	G	A	4: 62,306,273 (GRCm39)		probably null	Het
Sparc	G	T	11: 55,296,069 (GRCm39)	N87K	probably damaging	Het
Tcf12	T	C	9: 71,776,278 (GRCm39)		probably null	Het
Timm44	A	T	8: 4,316,860 (GRCm39)	F258I	probably benign	Het
Tm2d2	G	T	8: 25,508,095 (GRCm39)	V80L	possibly damaging	Het
Tpr	A	G	1: 150,320,199 (GRCm39)	D2249G	possibly damaging	Het
Trim50	G	T	5: 135,392,736 (GRCm39)	G217V	possibly damaging	Het
Ugcg	T	C	4: 59,217,216 (GRCm39)		probably null	Het
Vmn2r107	A	T	17: 20,565,868 (GRCm39)	H61L	probably benign	Het
Zfp84	A	G	7: 29,476,091 (GRCm39)	H261R	probably benign	Het
Zswim2	A	T	2: 83,748,301 (GRCm39)	M293K	probably benign	Het

Other mutations in Oprm1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01018:Oprm1	APN	10	6,987,170 (GRCm39)	utr 3 prime	probably benign
IGL02455:Oprm1	APN	10	6,780,219 (GRCm39)	missense	probably damaging	1.00
IGL03391:Oprm1	APN	10	6,964,077 (GRCm39)	intron	probably benign
IGL03410:Oprm1	APN	10	6,780,051 (GRCm39)	missense	probably damaging	1.00
IGL03048:Oprm1	UTSW	10	6,779,064 (GRCm39)	missense	probably damaging	1.00
R0189:Oprm1	UTSW	10	6,739,071 (GRCm39)	missense	possibly damaging	0.94
R0321:Oprm1	UTSW	10	6,779,183 (GRCm39)	missense	probably damaging	1.00
R0629:Oprm1	UTSW	10	6,782,604 (GRCm39)	splice site	probably null
R0730:Oprm1	UTSW	10	6,782,652 (GRCm39)	intron	probably benign
R1542:Oprm1	UTSW	10	6,738,960 (GRCm39)	missense	probably damaging	1.00
R1743:Oprm1	UTSW	10	6,780,105 (GRCm39)	missense	probably damaging	0.99
R1874:Oprm1	UTSW	10	6,739,035 (GRCm39)	missense	probably benign	0.17
R2864:Oprm1	UTSW	10	6,744,226 (GRCm39)	splice site	probably null
R2964:Oprm1	UTSW	10	6,738,914 (GRCm39)	missense	probably damaging	0.98
R3792:Oprm1	UTSW	10	6,789,544 (GRCm39)	missense	probably benign	0.00
R4008:Oprm1	UTSW	10	6,782,520 (GRCm39)	missense	probably benign
R4049:Oprm1	UTSW	10	6,779,087 (GRCm39)	missense	probably benign	0.36
R4088:Oprm1	UTSW	10	6,780,234 (GRCm39)	missense	probably damaging	1.00
R4724:Oprm1	UTSW	10	6,708,656 (GRCm39)	nonsense	probably null
R4812:Oprm1	UTSW	10	6,782,698 (GRCm39)	intron	probably benign
R4822:Oprm1	UTSW	10	6,779,036 (GRCm39)	missense	probably damaging	0.99
R4855:Oprm1	UTSW	10	6,788,468 (GRCm39)	missense	probably benign	0.01
R5072:Oprm1	UTSW	10	6,782,550 (GRCm39)	missense	probably benign	0.15
R5768:Oprm1	UTSW	10	6,739,026 (GRCm39)	missense	probably damaging	1.00
R5770:Oprm1	UTSW	10	6,739,026 (GRCm39)	missense	probably damaging	1.00
R5995:Oprm1	UTSW	10	6,782,520 (GRCm39)	missense	probably benign
R6327:Oprm1	UTSW	10	6,780,063 (GRCm39)	missense	probably damaging	0.99
R7135:Oprm1	UTSW	10	6,780,203 (GRCm39)	missense	possibly damaging	0.77
R7413:Oprm1	UTSW	10	6,778,919 (GRCm39)	missense	probably damaging	1.00
R7455:Oprm1	UTSW	10	6,780,204 (GRCm39)	missense	probably damaging	1.00
R8192:Oprm1	UTSW	10	6,788,417 (GRCm39)	missense	probably benign	0.04
R8210:Oprm1	UTSW	10	6,780,442 (GRCm39)	missense	probably benign	0.02
R8945:Oprm1	UTSW	10	6,782,644 (GRCm39)	intron	probably benign
R9054:Oprm1	UTSW	10	6,773,914 (GRCm39)	intron	probably benign
R9723:Oprm1	UTSW	10	6,788,514 (GRCm39)	missense	possibly damaging	0.66
R9726:Oprm1	UTSW	10	6,929,694 (GRCm39)	missense	probably benign	0.00
X0066:Oprm1	UTSW	10	6,780,462 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-02-04