Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01768:Vmn2r107'

154007

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL01768

Quality Score

Status

Chromosome

Chromosomal Location

20565687-20596034 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20565868 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 61 (H61L)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: H61L

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: H61L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aifm3	T	C	16: 17,324,141 (GRCm39)	V567A	possibly damaging	Het
Arnt	T	C	3: 95,398,327 (GRCm39)		probably benign	Het
C8b	G	A	4: 104,644,151 (GRCm39)	E273K	probably benign	Het
Capn5	C	T	7: 97,774,480 (GRCm39)	R570H	probably damaging	Het
Cdh9	A	T	15: 16,778,311 (GRCm39)	D42V	possibly damaging	Het
Cdk17	T	C	10: 93,044,123 (GRCm39)	S21P	probably damaging	Het
Cdkl3	T	A	11: 51,916,744 (GRCm39)	F291I	probably damaging	Het
Cfap210	A	T	2: 69,612,471 (GRCm39)		probably benign	Het
Clmn	T	C	12: 104,747,978 (GRCm39)	E523G	probably damaging	Het
Cyp4f14	A	T	17: 33,126,976 (GRCm39)	I318N	probably damaging	Het
Daam1	T	A	12: 72,036,659 (GRCm39)	F1068L	probably benign	Het
Ext2	A	G	2: 93,621,455 (GRCm39)		probably benign	Het
F5	T	A	1: 164,003,914 (GRCm39)	F236L	probably benign	Het
Fat2	A	G	11: 55,153,394 (GRCm39)	V3606A	probably damaging	Het
Gpam	G	A	19: 55,075,952 (GRCm39)	T220M	probably benign	Het
Hyal1	C	A	9: 107,456,338 (GRCm39)	L342I	probably damaging	Het
Ilvbl	C	A	10: 78,419,127 (GRCm39)	P459T	possibly damaging	Het
Itga5	A	G	15: 103,259,997 (GRCm39)	Y632H	probably benign	Het
Jkampl	A	T	6: 73,445,899 (GRCm39)	L217M	possibly damaging	Het
Krt73	T	C	15: 101,707,291 (GRCm39)	D299G	probably benign	Het
Lcp1	T	C	14: 75,461,573 (GRCm39)	V522A	probably benign	Het
Lmo3	A	G	6: 138,393,495 (GRCm39)	C53R	probably damaging	Het
Nsun7	T	C	5: 66,436,043 (GRCm39)	V305A	probably benign	Het
Oprm1	T	C	10: 6,779,186 (GRCm39)	S196P	probably damaging	Het
Or2y1e	G	A	11: 49,218,958 (GRCm39)	C240Y	probably damaging	Het
Or4z4	A	T	19: 12,076,403 (GRCm39)	I200N	probably damaging	Het
Or7e168	G	A	9: 19,720,456 (GRCm39)	V281M	possibly damaging	Het
Ovgp1	T	C	3: 105,888,667 (GRCm39)		probably null	Het
Pcdhb20	T	C	18: 37,639,768 (GRCm39)	F765L	possibly damaging	Het
Ppp4r4	T	C	12: 103,547,664 (GRCm39)	V3A	probably benign	Het
Ruvbl1	A	G	6: 88,474,253 (GRCm39)	I419V	probably benign	Het
Scara5	T	A	14: 65,927,224 (GRCm39)	C40*	probably null	Het
Siglec1	T	C	2: 130,916,314 (GRCm39)	Q1212R	probably benign	Het
Slc31a1	G	A	4: 62,306,273 (GRCm39)		probably null	Het
Sparc	G	T	11: 55,296,069 (GRCm39)	N87K	probably damaging	Het
Tcf12	T	C	9: 71,776,278 (GRCm39)		probably null	Het
Timm44	A	T	8: 4,316,860 (GRCm39)	F258I	probably benign	Het
Tm2d2	G	T	8: 25,508,095 (GRCm39)	V80L	possibly damaging	Het
Tpr	A	G	1: 150,320,199 (GRCm39)	D2249G	possibly damaging	Het
Trim50	G	T	5: 135,392,736 (GRCm39)	G217V	possibly damaging	Het
Ugcg	T	C	4: 59,217,216 (GRCm39)		probably null	Het
Zfp84	A	G	7: 29,476,091 (GRCm39)	H261R	probably benign	Het
Zswim2	A	T	2: 83,748,301 (GRCm39)	M293K	probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20,596,009 (GRCm39)	missense	probably damaging	0.98
IGL02086:Vmn2r107	APN	17	20,578,062 (GRCm39)	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20,595,168 (GRCm39)	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20,577,039 (GRCm39)	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20,595,823 (GRCm39)	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20,577,006 (GRCm39)	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20,578,017 (GRCm39)	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20,595,974 (GRCm39)	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20,577,173 (GRCm39)	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20,577,038 (GRCm39)	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20,578,220 (GRCm39)	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20,565,766 (GRCm39)	missense	probably benign
BB006:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20,565,873 (GRCm39)	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20,595,085 (GRCm39)	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20,595,394 (GRCm39)	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20,578,021 (GRCm39)	missense	probably benign
R0621:Vmn2r107	UTSW	17	20,595,252 (GRCm39)	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20,575,916 (GRCm39)	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20,576,860 (GRCm39)	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20,578,031 (GRCm39)	missense	probably benign
R1237:Vmn2r107	UTSW	17	20,576,947 (GRCm39)	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20,595,109 (GRCm39)	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20,576,775 (GRCm39)	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20,565,840 (GRCm39)	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20,575,879 (GRCm39)	splice site	probably null
R2009:Vmn2r107	UTSW	17	20,595,729 (GRCm39)	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20,595,549 (GRCm39)	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20,595,904 (GRCm39)	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20,595,817 (GRCm39)	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20,580,607 (GRCm39)	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20,595,151 (GRCm39)	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20,595,717 (GRCm39)	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20,595,483 (GRCm39)	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20,576,041 (GRCm39)	missense	probably benign
R4963:Vmn2r107	UTSW	17	20,595,403 (GRCm39)	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20,576,015 (GRCm39)	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20,595,426 (GRCm39)	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20,595,316 (GRCm39)	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20,565,849 (GRCm39)	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20,576,044 (GRCm39)	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20,595,939 (GRCm39)	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20,595,637 (GRCm39)	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20,577,141 (GRCm39)	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20,576,138 (GRCm39)	missense	probably benign
R7448:Vmn2r107	UTSW	17	20,595,994 (GRCm39)	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20,595,271 (GRCm39)	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20,595,634 (GRCm39)	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20,580,635 (GRCm39)	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20,576,901 (GRCm39)	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20,577,270 (GRCm39)	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20,595,808 (GRCm39)	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20,580,614 (GRCm39)	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20,577,239 (GRCm39)	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20,577,051 (GRCm39)	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20,595,149 (GRCm39)	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20,580,661 (GRCm39)	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20,577,262 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20,577,230 (GRCm39)	missense	possibly damaging	0.85

Posted On

2014-02-04