Incidental Mutation 'R0030:Lcn10'
ID 15404
Institutional Source Beutler Lab
Gene Symbol Lcn10
Ensembl Gene ENSMUSG00000047356
Gene Name lipocalin 10
Synonyms 9230112J07Rik
MMRRC Submission 038324-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0030 (G1)
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 25572738-25576093 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25575093 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 154 (F154L)
Ref Sequence ENSEMBL: ENSMUSP00000059353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058912] [ENSMUST00000059693] [ENSMUST00000114197] [ENSMUST00000114199]
AlphaFold Q810Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000058912
AA Change: F154L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000059353
Gene: ENSMUSG00000047356
AA Change: F154L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Lipocalin 36 169 1.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000059693
SMART Domains Protein: ENSMUSP00000055660
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114197
SMART Domains Protein: ENSMUSP00000109835
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 4.8e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114199
SMART Domains Protein: ENSMUSP00000109837
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:Lipocalin 33 172 2.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139441
Meta Mutation Damage Score 0.7688 question?
Coding Region Coverage
  • 1x: 78.5%
  • 3x: 68.6%
  • 10x: 42.5%
  • 20x: 22.6%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aebp2 A C 6: 140,583,473 (GRCm39) S316R probably damaging Het
Brwd1 A G 16: 95,822,456 (GRCm39) S1250P probably damaging Het
Cacna1s T C 1: 136,022,727 (GRCm39) probably null Het
Cass4 G T 2: 172,269,762 (GRCm39) E617* probably null Het
Cct4 T C 11: 22,951,357 (GRCm39) probably benign Het
Cdh20 C T 1: 110,065,798 (GRCm39) Q691* probably null Het
Crip1 G A 12: 113,116,996 (GRCm39) probably null Het
Dnah5 A T 15: 28,451,663 (GRCm39) D4367V probably benign Het
Dock3 A G 9: 106,789,512 (GRCm39) V1514A possibly damaging Het
Eps15l1 A G 8: 73,126,894 (GRCm39) S646P probably benign Het
Faap24 A T 7: 35,092,285 (GRCm39) F211I probably damaging Het
Flrt3 A T 2: 140,502,237 (GRCm39) Y464N probably damaging Het
Foxi2 A G 7: 135,013,345 (GRCm39) T192A probably damaging Het
Gm7298 T A 6: 121,751,009 (GRCm39) F695L probably benign Het
Ifnk T G 4: 35,152,489 (GRCm39) V139G probably benign Het
Kif18a A T 2: 109,163,663 (GRCm39) I671L probably benign Het
Med12l T G 3: 59,156,076 (GRCm39) L1198R probably damaging Het
Mmp23 G A 4: 155,735,768 (GRCm39) R268* probably null Het
Mrps30 T C 13: 118,519,531 (GRCm39) D298G possibly damaging Het
Myh7 T A 14: 55,229,427 (GRCm39) T124S probably benign Het
Odf4 T A 11: 68,817,767 (GRCm39) E9D probably benign Het
Ptchd4 T A 17: 42,627,999 (GRCm39) C153* probably null Het
Scp2 T A 4: 107,964,887 (GRCm39) probably null Het
Slc16a10 A G 10: 39,952,819 (GRCm39) V225A probably benign Het
Slc66a1 A G 4: 139,033,764 (GRCm39) S52P probably damaging Het
Tbk1 A G 10: 121,397,529 (GRCm39) V381A probably benign Het
Tdrd6 T C 17: 43,937,482 (GRCm39) K1189E possibly damaging Het
Ttc39a C A 4: 109,280,170 (GRCm39) H151N probably benign Het
Ush2a C T 1: 188,554,854 (GRCm39) T3544M possibly damaging Het
Vnn1 A G 10: 23,776,744 (GRCm39) H365R probably benign Het
Other mutations in Lcn10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02738:Lcn10 APN 2 25,574,032 (GRCm39) unclassified probably benign
R1832:Lcn10 UTSW 2 25,575,151 (GRCm39) missense probably damaging 1.00
R1931:Lcn10 UTSW 2 25,574,347 (GRCm39) missense probably damaging 1.00
R2890:Lcn10 UTSW 2 25,573,642 (GRCm39) missense probably damaging 1.00
R4364:Lcn10 UTSW 2 25,574,052 (GRCm39) missense probably damaging 1.00
R5511:Lcn10 UTSW 2 25,572,841 (GRCm39) missense probably benign 0.00
R6219:Lcn10 UTSW 2 25,573,587 (GRCm39) nonsense probably null
R8837:Lcn10 UTSW 2 25,575,298 (GRCm39) unclassified probably benign
Posted On 2012-12-17