Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01775:Gm14496'

154061

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm14496

Ensembl Gene

ENSMUSG00000098505

Gene Name

predicted gene 14496

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01775

Quality Score

Status

Chromosome

Chromosomal Location

181633019-181642880 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 181642125 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 599 (T599S)

Ref Sequence

ENSEMBL: ENSMUSP00000071670 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071760]

AlphaFold

K7N5U4

Predicted Effect

probably benign
Transcript: ENSMUST00000071760
AA Change: T599S

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000071670
Gene: ENSMUSG00000098505
AA Change: T599S

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	456	1.3e-30	PFAM
Pfam:NCD3G	508	562	1.9e-18	PFAM
Pfam:7tm_3	595	830	7.9e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000089788

SMART Domains

Protein: ENSMUSP00000087221
Gene: ENSMUSG00000053277

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	425	2.8e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184507

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatf	A	T	11: 84,361,963 (GRCm39)	L333Q	probably damaging	Het
Ablim3	A	T	18: 61,949,989 (GRCm39)		probably benign	Het
Acsl6	T	C	11: 54,236,826 (GRCm39)		probably benign	Het
Adra1b	T	A	11: 43,726,128 (GRCm39)	D263V	probably damaging	Het
Aicda	G	A	6: 122,538,012 (GRCm39)	V57M	probably damaging	Het
C2cd3	T	C	7: 100,092,638 (GRCm39)	W494R	probably damaging	Het
Ccnb1	T	C	13: 100,920,017 (GRCm39)	S165G	probably benign	Het
Cnot4	A	T	6: 35,046,411 (GRCm39)		probably benign	Het
Dph6	A	T	2: 114,348,776 (GRCm39)		probably benign	Het
Emc3	A	G	6: 113,508,296 (GRCm39)	S50P	possibly damaging	Het
Fbxo45	A	C	16: 32,052,093 (GRCm39)		probably null	Het
Gspt1	T	C	16: 11,041,159 (GRCm39)	I535V	possibly damaging	Het
Hemk1	A	G	9: 107,207,995 (GRCm39)	I215T	possibly damaging	Het
Ighm	A	T	12: 113,386,087 (GRCm39)	C88S	unknown	Het
Itih2	A	C	2: 10,134,097 (GRCm39)	D38E	probably benign	Het
Lat	C	A	7: 125,967,261 (GRCm39)	V113L	probably benign	Het
Mical2	T	A	7: 111,981,269 (GRCm39)	F480L	possibly damaging	Het
Mki67	A	T	7: 135,300,005 (GRCm39)	S1676R	possibly damaging	Het
Msh2	A	T	17: 87,990,074 (GRCm39)	N254I	possibly damaging	Het
Naglu	T	C	11: 100,964,921 (GRCm39)	M336T	probably damaging	Het
Nhsl1	C	T	10: 18,400,222 (GRCm39)	R483C	probably damaging	Het
Nsmaf	C	T	4: 6,396,791 (GRCm39)	E899K	possibly damaging	Het
Nup85	T	C	11: 115,471,593 (GRCm39)	Y181H	probably damaging	Het
Or52n2	A	T	7: 104,542,499 (GRCm39)	M112K	possibly damaging	Het
Or5m5	T	C	2: 85,815,014 (GRCm39)	S277P	probably damaging	Het
Or7g35	A	T	9: 19,496,001 (GRCm39)	Q56L	probably benign	Het
Or8g23	C	A	9: 38,971,763 (GRCm39)	L66F	probably damaging	Het
P2rx3	C	T	2: 84,854,501 (GRCm39)	R91H	probably benign	Het
Plag1	T	C	4: 3,904,513 (GRCm39)	D226G	probably damaging	Het
Pofut1	T	A	2: 153,090,393 (GRCm39)	F96I	probably damaging	Het
Prim1	A	G	10: 127,865,112 (GRCm39)	N399S	probably benign	Het
Prkd3	G	T	17: 79,320,189 (GRCm39)	T51K	probably damaging	Het
Ptprc	T	C	1: 137,992,497 (GRCm39)	Y1210C	probably damaging	Het
Rbm43	A	T	2: 51,815,460 (GRCm39)	S254T	probably damaging	Het
Retsat	G	A	6: 72,584,300 (GRCm39)	R528Q	probably damaging	Het
Rlig1	A	T	10: 100,419,799 (GRCm39)	L94Q	probably benign	Het
Rps8	C	A	4: 117,012,249 (GRCm39)	R56L	probably benign	Het
Samhd1	A	T	2: 156,956,250 (GRCm39)		probably benign	Het
Sfxn1	T	C	13: 54,259,758 (GRCm39)		probably benign	Het
Stk33	T	A	7: 108,911,574 (GRCm39)	E396D	possibly damaging	Het
Tcaim	T	C	9: 122,647,890 (GRCm39)	V135A	probably damaging	Het
Thsd7b	A	G	1: 129,556,676 (GRCm39)	D421G	probably damaging	Het
Unc80	A	G	1: 66,640,215 (GRCm39)	D1374G	possibly damaging	Het
Wnk2	C	A	13: 49,224,586 (GRCm39)	D232Y	probably damaging	Het
Zfand1	T	C	3: 10,409,926 (GRCm39)	T145A	probably damaging	Het

Other mutations in Gm14496

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01144:Gm14496	APN	2	181,636,814 (GRCm39)	missense	probably damaging	1.00
IGL01300:Gm14496	APN	2	181,642,753 (GRCm39)	missense	probably damaging	1.00
IGL01328:Gm14496	APN	2	181,637,673 (GRCm39)	missense	probably damaging	1.00
IGL01526:Gm14496	APN	2	181,637,458 (GRCm39)	missense	probably benign	0.12
IGL01576:Gm14496	APN	2	181,633,164 (GRCm39)	missense	possibly damaging	0.92
IGL02020:Gm14496	APN	2	181,637,882 (GRCm39)	missense	possibly damaging	0.95
IGL02150:Gm14496	APN	2	181,633,140 (GRCm39)	missense	probably damaging	0.99
IGL02170:Gm14496	APN	2	181,638,144 (GRCm39)	missense	probably damaging	1.00
IGL02262:Gm14496	APN	2	181,637,805 (GRCm39)	missense	probably damaging	1.00
IGL02398:Gm14496	APN	2	181,637,963 (GRCm39)	missense	probably benign	0.09
IGL02414:Gm14496	APN	2	181,633,198 (GRCm39)	missense	probably benign	0.03
IGL02541:Gm14496	APN	2	181,642,186 (GRCm39)	missense	probably benign	0.29
IGL02741:Gm14496	APN	2	181,633,136 (GRCm39)	missense	probably benign
IGL02933:Gm14496	APN	2	181,642,256 (GRCm39)	missense	probably benign	0.15
IGL03214:Gm14496	APN	2	181,642,329 (GRCm39)	missense	probably damaging	1.00
FR4342:Gm14496	UTSW	2	181,637,699 (GRCm39)	missense	probably benign	0.01
R0158:Gm14496	UTSW	2	181,639,206 (GRCm39)	missense	probably benign	0.07
R0271:Gm14496	UTSW	2	181,637,747 (GRCm39)	missense	probably benign	0.44
R0611:Gm14496	UTSW	2	181,636,904 (GRCm39)	missense	probably benign	0.00
R0833:Gm14496	UTSW	2	181,638,059 (GRCm39)	missense	probably damaging	0.99
R0834:Gm14496	UTSW	2	181,637,480 (GRCm39)	missense	probably benign	0.00
R0906:Gm14496	UTSW	2	181,642,308 (GRCm39)	missense	probably damaging	0.98
R1298:Gm14496	UTSW	2	181,637,885 (GRCm39)	missense	probably benign	0.39
R1500:Gm14496	UTSW	2	181,633,026 (GRCm39)	missense	probably benign	0.21
R1585:Gm14496	UTSW	2	181,638,002 (GRCm39)	missense	possibly damaging	0.79
R1610:Gm14496	UTSW	2	181,637,972 (GRCm39)	missense	probably benign	0.01
R1627:Gm14496	UTSW	2	181,640,571 (GRCm39)	missense	probably damaging	1.00
R1635:Gm14496	UTSW	2	181,642,837 (GRCm39)	missense	possibly damaging	0.88
R1663:Gm14496	UTSW	2	181,639,230 (GRCm39)	missense	probably benign	0.03
R1792:Gm14496	UTSW	2	181,637,946 (GRCm39)	missense	probably benign	0.00
R1888:Gm14496	UTSW	2	181,641,989 (GRCm39)	nonsense	probably null
R1888:Gm14496	UTSW	2	181,641,989 (GRCm39)	nonsense	probably null
R1922:Gm14496	UTSW	2	181,642,797 (GRCm39)	missense	probably benign	0.22
R2081:Gm14496	UTSW	2	181,642,272 (GRCm39)	missense	probably damaging	1.00
R2102:Gm14496	UTSW	2	181,633,127 (GRCm39)	missense	possibly damaging	0.88
R2176:Gm14496	UTSW	2	181,633,130 (GRCm39)	missense	probably benign
R4154:Gm14496	UTSW	2	181,636,872 (GRCm39)	missense	probably benign	0.01
R4789:Gm14496	UTSW	2	181,637,577 (GRCm39)	missense	possibly damaging	0.85
R4873:Gm14496	UTSW	2	181,639,226 (GRCm39)	missense	probably damaging	0.99
R4875:Gm14496	UTSW	2	181,639,226 (GRCm39)	missense	probably damaging	0.99
R5020:Gm14496	UTSW	2	181,633,152 (GRCm39)	missense	possibly damaging	0.67
R5354:Gm14496	UTSW	2	181,642,602 (GRCm39)	missense	probably damaging	1.00
R5361:Gm14496	UTSW	2	181,642,147 (GRCm39)	missense	probably benign	0.07
R5457:Gm14496	UTSW	2	181,639,401 (GRCm39)	missense	probably damaging	0.96
R5589:Gm14496	UTSW	2	181,637,674 (GRCm39)	nonsense	probably null
R5655:Gm14496	UTSW	2	181,637,975 (GRCm39)	missense	probably benign	0.06
R6007:Gm14496	UTSW	2	181,639,323 (GRCm39)	missense	probably benign	0.37
R6123:Gm14496	UTSW	2	181,633,020 (GRCm39)	start codon destroyed	probably null	1.00
R6159:Gm14496	UTSW	2	181,638,050 (GRCm39)	missense	probably benign	0.01
R6168:Gm14496	UTSW	2	181,642,750 (GRCm39)	missense	probably damaging	1.00
R6454:Gm14496	UTSW	2	181,638,015 (GRCm39)	missense	probably damaging	0.97
R6502:Gm14496	UTSW	2	181,642,386 (GRCm39)	missense	probably benign	0.01
R6649:Gm14496	UTSW	2	181,639,269 (GRCm39)	missense	possibly damaging	0.83
R6996:Gm14496	UTSW	2	181,637,997 (GRCm39)	missense	probably damaging	1.00
R7043:Gm14496	UTSW	2	181,642,120 (GRCm39)	missense	possibly damaging	0.70
R7317:Gm14496	UTSW	2	181,637,613 (GRCm39)	missense	possibly damaging	0.56
R7354:Gm14496	UTSW	2	181,642,479 (GRCm39)	missense	probably damaging	1.00
R7565:Gm14496	UTSW	2	181,642,630 (GRCm39)	missense	probably damaging	0.99
R7565:Gm14496	UTSW	2	181,633,050 (GRCm39)	missense	possibly damaging	0.84
R7669:Gm14496	UTSW	2	181,637,711 (GRCm39)	missense	possibly damaging	0.95
R7828:Gm14496	UTSW	2	181,633,171 (GRCm39)	nonsense	probably null
R7870:Gm14496	UTSW	2	181,637,906 (GRCm39)	missense	probably benign	0.09
R8006:Gm14496	UTSW	2	181,637,669 (GRCm39)	missense	probably benign	0.03
R8379:Gm14496	UTSW	2	181,642,275 (GRCm39)	missense	probably damaging	0.99
R9174:Gm14496	UTSW	2	181,642,797 (GRCm39)	missense	possibly damaging	0.95
R9416:Gm14496	UTSW	2	181,640,647 (GRCm39)	missense	probably damaging	1.00
R9429:Gm14496	UTSW	2	181,637,934 (GRCm39)	missense	possibly damaging	0.60
R9463:Gm14496	UTSW	2	181,642,256 (GRCm39)	missense	probably benign	0.15
R9499:Gm14496	UTSW	2	181,638,179 (GRCm39)	missense	probably benign	0.00
R9581:Gm14496	UTSW	2	181,642,047 (GRCm39)	missense	probably benign	0.10
X0058:Gm14496	UTSW	2	181,637,779 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-02-04