Incidental Mutation 'IGL01780:Mrgpra6'
ID154143
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra6
Ensembl Gene ENSMUSG00000052303
Gene NameMAS-related GPR, member A6
SynonymsMrgA6
Accession Numbers

Genbank: NM_205821; MGI: 3033107

Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL01780
Quality Score
Status
Chromosome7
Chromosomal Location47185707-47204920 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 47188749 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 234 (T234A)
Ref Sequence ENSEMBL: ENSMUSP00000140353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]
Predicted Effect probably damaging
Transcript: ENSMUST00000073793
AA Change: T203A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303
AA Change: T203A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 17 198 5.9e-8 PFAM
Pfam:7tm_1 26 258 5.2e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000186456
AA Change: T234A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303
AA Change: T234A

DomainStartEndE-ValueType
low complexity region 13 26 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 228 1.1e-5 PFAM
Pfam:7tm_1 57 270 1e-15 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010111I01Rik A G 13: 63,210,125 N648D probably benign Het
Abhd8 A G 8: 71,461,477 V169A probably benign Het
BC024139 C A 15: 76,121,143 L506F probably benign Het
Cfap65 A T 1: 74,928,348 C190* probably null Het
Cib2 A T 9: 54,549,886 H31Q probably damaging Het
Emb A G 13: 117,249,471 probably benign Het
Eml6 T C 11: 29,805,175 M867V probably benign Het
Flnc A T 6: 29,438,493 K129* probably null Het
Gckr C A 5: 31,307,790 H368N possibly damaging Het
Gmds A T 13: 32,225,162 Y106* probably null Het
Homez T C 14: 54,857,898 T118A probably damaging Het
Kcnh7 G A 2: 62,837,163 T344I probably benign Het
Kcnt2 A G 1: 140,351,269 I53V probably benign Het
Krt13 A T 11: 100,119,713 L207Q probably damaging Het
Lipo2 A G 19: 33,730,948 L222P possibly damaging Het
Lrp2 A C 2: 69,486,184 V2151G possibly damaging Het
Mrc2 A G 11: 105,325,721 D112G probably damaging Het
Mroh2b A G 15: 4,912,000 N338S probably benign Het
Mrpl23 T A 7: 142,536,065 probably benign Het
Myo18a A G 11: 77,850,247 N1442S probably benign Het
Nxn A G 11: 76,274,654 probably benign Het
Olfr1132 T C 2: 87,635,080 I222M possibly damaging Het
Osmr A T 15: 6,828,663 N441K probably benign Het
Patl2 A C 2: 122,121,846 S468R probably damaging Het
Pcdhb1 T C 18: 37,266,522 S509P probably damaging Het
Pmp22 G T 11: 63,158,308 V126F probably benign Het
Prom1 A G 5: 44,029,604 probably benign Het
Prss1 C A 6: 41,463,205 Q159K probably damaging Het
Psd3 G T 8: 67,963,869 H459N probably benign Het
Rasgrp1 A G 2: 117,284,878 L743P probably benign Het
Rpusd4 G A 9: 35,268,424 R71Q probably damaging Het
Rsf1 C T 7: 97,664,770 probably benign Het
Scaf11 T C 15: 96,420,844 T280A possibly damaging Het
Slc16a4 A G 3: 107,303,099 I362V probably benign Het
Syt16 T C 12: 74,266,842 V514A probably benign Het
Tdpoz2 A G 3: 93,652,428 V79A possibly damaging Het
Tenm2 A G 11: 36,046,941 M1635T probably benign Het
Uhrf1bp1 T C 17: 27,893,500 L1221P probably damaging Het
Vmn1r195 A G 13: 22,279,085 T242A probably benign Het
Zfp423 A G 8: 87,781,508 V736A probably damaging Het
Other mutations in Mrgpra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01645:Mrgpra6 APN 7 47185933 missense probably benign 0.00
IGL01801:Mrgpra6 APN 7 47185824 missense possibly damaging 0.90
IGL02158:Mrgpra6 APN 7 47185952 nonsense probably null
IGL02715:Mrgpra6 APN 7 47188648 splice site probably benign
IGL02896:Mrgpra6 APN 7 47188907 missense probably benign 0.02
D4216:Mrgpra6 UTSW 7 47188756 missense probably damaging 0.96
R1566:Mrgpra6 UTSW 7 47188904 missense probably benign 0.02
R4016:Mrgpra6 UTSW 7 47188715 missense possibly damaging 0.76
R5051:Mrgpra6 UTSW 7 47185942 missense probably benign 0.00
R5384:Mrgpra6 UTSW 7 47188881 missense probably damaging 1.00
R5386:Mrgpra6 UTSW 7 47188881 missense probably damaging 1.00
R5638:Mrgpra6 UTSW 7 47185909 missense probably damaging 1.00
R5860:Mrgpra6 UTSW 7 47189351 missense probably benign 0.41
R6633:Mrgpra6 UTSW 7 47188745 missense possibly damaging 0.89
R6952:Mrgpra6 UTSW 7 47185945 missense probably benign 0.01
R6980:Mrgpra6 UTSW 7 47188949 missense probably damaging 0.97
Posted On2014-02-04