Incidental Mutation 'IGL01783:Gpr18'
ID 154199
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr18
Ensembl Gene ENSMUSG00000050350
Gene Name G protein-coupled receptor 18
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL01783
Quality Score
Status
Chromosome 14
Chromosomal Location 122148846-122153300 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 122149789 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 79 (M79L)
Ref Sequence ENSEMBL: ENSMUSP00000061410 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039803] [ENSMUST00000055475] [ENSMUST00000226998]
AlphaFold Q8K1Z6
Predicted Effect probably benign
Transcript: ENSMUST00000039803
SMART Domains Protein: ENSMUSP00000043245
Gene: ENSMUSG00000041765

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 92 114 N/A INTRINSIC
transmembrane domain 129 151 N/A INTRINSIC
transmembrane domain 164 186 N/A INTRINSIC
low complexity region 261 269 N/A INTRINSIC
UBA 307 344 1.11e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000055475
AA Change: M79L

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000061410
Gene: ENSMUSG00000050350
AA Change: M79L

DomainStartEndE-ValueType
Pfam:7tm_1 39 286 4.3e-35 PFAM
low complexity region 307 324 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000226998
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227684
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction in CD8-positive, alpha-beta T cell number and CD8-positive, gamma-delta intraepithelial T cell number. Mice homozygous for a different knock-out allele exhibit increased susceptibility to E. coli infection and diminished response to RvD2. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd13 T C 8: 10,037,900 (GRCm39) Y166H possibly damaging Het
Abi3bp G A 16: 56,353,332 (GRCm39) probably null Het
Actrt3 T C 3: 30,652,624 (GRCm39) T157A probably benign Het
Adam26b T C 8: 43,974,798 (GRCm39) K68R probably benign Het
Adgrg7 A G 16: 56,568,282 (GRCm39) probably null Het
Ano6 T C 15: 95,860,143 (GRCm39) I755T possibly damaging Het
Basp1 T C 15: 25,364,953 (GRCm39) N15D unknown Het
Bod1l T C 5: 41,966,055 (GRCm39) N2670S probably benign Het
Btbd3 T A 2: 138,125,656 (GRCm39) I280N probably damaging Het
Cdh16 T A 8: 105,344,488 (GRCm39) Y17F probably damaging Het
Clmp G T 9: 40,693,703 (GRCm39) G307W possibly damaging Het
Clrn2 C A 5: 45,617,503 (GRCm39) Q125K probably benign Het
Ctnna3 C T 10: 63,656,248 (GRCm39) A276V possibly damaging Het
Dram2 A T 3: 106,480,972 (GRCm39) T172S possibly damaging Het
Dync2h1 G A 9: 7,118,822 (GRCm39) probably benign Het
Ezr T C 17: 7,009,888 (GRCm39) probably benign Het
Gbe1 T A 16: 70,275,257 (GRCm39) D352E probably damaging Het
Gbe1 T C 16: 70,198,743 (GRCm39) probably null Het
Gss T C 2: 155,413,479 (GRCm39) Y196C probably damaging Het
Gtpbp1 T C 15: 79,600,398 (GRCm39) S444P probably damaging Het
Hecw1 C T 13: 14,452,878 (GRCm39) R712K probably damaging Het
Helz2 T G 2: 180,874,674 (GRCm39) D1940A probably damaging Het
Hmcn1 A T 1: 150,491,051 (GRCm39) V4166E possibly damaging Het
Klkb1 T C 8: 45,729,428 (GRCm39) Y297C probably damaging Het
Krt75 T A 15: 101,473,364 (GRCm39) I537F probably benign Het
Lrp1b T A 2: 41,202,584 (GRCm39) T1176S probably damaging Het
Nid2 T C 14: 19,818,745 (GRCm39) L413P probably benign Het
Or10ag57 T A 2: 87,218,187 (GRCm39) M46K possibly damaging Het
Or10ag57 G T 2: 87,218,182 (GRCm39) L44F probably benign Het
Or4c11 T C 2: 88,695,186 (GRCm39) L79P probably damaging Het
Or5t7 A G 2: 86,507,425 (GRCm39) V84A probably benign Het
Piwil1 A G 5: 128,820,890 (GRCm39) N272D probably benign Het
Ppfia3 T C 7: 45,009,481 (GRCm39) probably null Het
Prkg1 A G 19: 30,602,089 (GRCm39) V389A probably damaging Het
Sema3a C A 5: 13,611,767 (GRCm39) S344R probably damaging Het
Serpina3j T C 12: 104,284,750 (GRCm39) L309P probably damaging Het
Slc15a1 A G 14: 121,708,688 (GRCm39) probably null Het
Sp8 G T 12: 118,812,759 (GRCm39) A205S probably benign Het
Speer4a1 T A 5: 26,240,045 (GRCm39) Q235L possibly damaging Het
St6gal1 A G 16: 23,140,305 (GRCm39) T159A probably benign Het
Tbrg1 G T 9: 37,565,596 (GRCm39) P119T possibly damaging Het
Tmem59l T C 8: 70,939,874 (GRCm39) T32A probably damaging Het
Trmt13 G A 3: 116,376,561 (GRCm39) R277* probably null Het
Zfp316 A G 5: 143,248,631 (GRCm39) F205S unknown Het
Zfp418 G T 7: 7,184,448 (GRCm39) W137L possibly damaging Het
Zp3r A T 1: 130,526,603 (GRCm39) V200D possibly damaging Het
Other mutations in Gpr18
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1709:Gpr18 UTSW 14 122,149,404 (GRCm39) missense probably damaging 1.00
R2280:Gpr18 UTSW 14 122,150,017 (GRCm39) missense probably benign 0.02
R3687:Gpr18 UTSW 14 122,149,873 (GRCm39) missense probably damaging 1.00
R4118:Gpr18 UTSW 14 122,149,968 (GRCm39) missense probably benign 0.00
R4623:Gpr18 UTSW 14 122,149,579 (GRCm39) missense probably damaging 1.00
R4687:Gpr18 UTSW 14 122,149,090 (GRCm39) nonsense probably null
R5503:Gpr18 UTSW 14 122,149,159 (GRCm39) missense probably damaging 1.00
R6715:Gpr18 UTSW 14 122,149,389 (GRCm39) missense possibly damaging 0.88
R7998:Gpr18 UTSW 14 122,149,393 (GRCm39) missense probably benign 0.01
R9036:Gpr18 UTSW 14 122,149,667 (GRCm39) missense probably damaging 1.00
R9131:Gpr18 UTSW 14 122,149,173 (GRCm39) missense probably benign 0.42
R9655:Gpr18 UTSW 14 122,149,992 (GRCm39) missense probably benign
Posted On 2014-02-04