Incidental Mutation 'IGL01814:Zfp938'
| ID |
154362 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp938
|
| Ensembl Gene |
ENSMUSG00000062931 |
| Gene Name |
zinc finger protein 938 |
| Synonyms |
B230315N10Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.075)
|
| Stock # |
IGL01814
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
82060684-82077114 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 82062052 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 189
(D189E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047110
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041264]
[ENSMUST00000156218]
|
| AlphaFold |
E9Q9G3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041264
AA Change: D189E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: D189E
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
5.28e-14 |
SMART |
|
ZnF_C2H2
|
161 |
188 |
2.82e1 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
4.65e-1 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
491 |
513 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
519 |
541 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
547 |
569 |
2.4e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156218
|
| SMART Domains |
Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
5.28e-14 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afg3l2 |
T |
A |
18: 67,538,544 (GRCm39) |
N738I |
probably benign |
Het |
| B3galnt2 |
A |
G |
13: 14,161,938 (GRCm39) |
S1G |
probably damaging |
Het |
| Btbd9 |
T |
C |
17: 30,518,509 (GRCm39) |
I484V |
probably benign |
Het |
| Chd6 |
T |
C |
2: 160,901,849 (GRCm39) |
K8R |
probably benign |
Het |
| Csmd1 |
A |
C |
8: 16,551,389 (GRCm39) |
L279R |
probably damaging |
Het |
| Dmxl1 |
G |
T |
18: 49,997,935 (GRCm39) |
V708F |
probably damaging |
Het |
| Dnajc24 |
C |
T |
2: 105,811,429 (GRCm39) |
G49R |
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,301,237 (GRCm39) |
M198T |
probably benign |
Het |
| Dtx3l |
T |
A |
16: 35,751,872 (GRCm39) |
D683V |
probably benign |
Het |
| Duox1 |
A |
G |
2: 122,176,753 (GRCm39) |
T1425A |
probably damaging |
Het |
| Enpp3 |
G |
A |
10: 24,667,923 (GRCm39) |
P510S |
possibly damaging |
Het |
| Iars2 |
G |
T |
1: 185,034,972 (GRCm39) |
Y590* |
probably null |
Het |
| Itgb7 |
T |
C |
15: 102,131,852 (GRCm39) |
R244G |
possibly damaging |
Het |
| Itpr2 |
T |
A |
6: 146,134,044 (GRCm39) |
R1820S |
probably benign |
Het |
| Matn3 |
T |
C |
12: 9,002,091 (GRCm39) |
V101A |
probably damaging |
Het |
| Neurod1 |
C |
T |
2: 79,285,003 (GRCm39) |
V127M |
probably damaging |
Het |
| Or56a5 |
T |
C |
7: 104,792,811 (GRCm39) |
I236V |
possibly damaging |
Het |
| Or9i1b |
T |
A |
19: 13,896,892 (GRCm39) |
C169* |
probably null |
Het |
| Pde10a |
A |
G |
17: 9,147,939 (GRCm39) |
M1V |
probably null |
Het |
| Pdk4 |
A |
G |
6: 5,491,828 (GRCm39) |
|
probably null |
Het |
| Ptchd4 |
A |
T |
17: 42,814,177 (GRCm39) |
I693F |
possibly damaging |
Het |
| Scml4 |
C |
T |
10: 42,811,041 (GRCm39) |
R194C |
probably damaging |
Het |
| Slc24a4 |
T |
C |
12: 102,220,877 (GRCm39) |
V436A |
probably benign |
Het |
| Slc9a3 |
C |
A |
13: 74,314,091 (GRCm39) |
R800S |
probably damaging |
Het |
| Smchd1 |
C |
A |
17: 71,685,182 (GRCm39) |
M1415I |
probably benign |
Het |
| Syndig1 |
T |
A |
2: 149,741,690 (GRCm39) |
I92N |
probably damaging |
Het |
| Tchhl1 |
T |
C |
3: 93,377,656 (GRCm39) |
V120A |
possibly damaging |
Het |
| Thumpd3 |
C |
T |
6: 113,040,112 (GRCm39) |
T332I |
possibly damaging |
Het |
| Tmem101 |
G |
A |
11: 102,044,284 (GRCm39) |
T201M |
possibly damaging |
Het |
| Trip11 |
T |
C |
12: 101,850,747 (GRCm39) |
T1106A |
probably damaging |
Het |
| Ttc41 |
C |
T |
10: 86,566,890 (GRCm39) |
R519C |
probably damaging |
Het |
| Xirp1 |
T |
A |
9: 119,846,985 (GRCm39) |
M633L |
probably damaging |
Het |
|
| Other mutations in Zfp938 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00659:Zfp938
|
APN |
10 |
82,063,355 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00743:Zfp938
|
APN |
10 |
82,062,317 (GRCm39) |
missense |
probably benign |
|
|
IGL01764:Zfp938
|
APN |
10 |
82,063,624 (GRCm39) |
splice site |
probably benign |
|
|
IGL02244:Zfp938
|
APN |
10 |
82,061,906 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02865:Zfp938
|
APN |
10 |
82,062,026 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0372:Zfp938
|
UTSW |
10 |
82,063,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0666:Zfp938
|
UTSW |
10 |
82,061,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Zfp938
|
UTSW |
10 |
82,061,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1453:Zfp938
|
UTSW |
10 |
82,063,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1672:Zfp938
|
UTSW |
10 |
82,060,982 (GRCm39) |
missense |
probably benign |
|
|
R1929:Zfp938
|
UTSW |
10 |
82,061,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Zfp938
|
UTSW |
10 |
82,061,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2127:Zfp938
|
UTSW |
10 |
82,061,876 (GRCm39) |
missense |
probably benign |
|
|
R2271:Zfp938
|
UTSW |
10 |
82,061,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2900:Zfp938
|
UTSW |
10 |
82,061,340 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4502:Zfp938
|
UTSW |
10 |
82,062,105 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4503:Zfp938
|
UTSW |
10 |
82,062,105 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4886:Zfp938
|
UTSW |
10 |
82,061,957 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4934:Zfp938
|
UTSW |
10 |
82,062,012 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5174:Zfp938
|
UTSW |
10 |
82,061,838 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5410:Zfp938
|
UTSW |
10 |
82,061,092 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6284:Zfp938
|
UTSW |
10 |
82,063,400 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6491:Zfp938
|
UTSW |
10 |
82,063,363 (GRCm39) |
makesense |
probably null |
|
|
R6575:Zfp938
|
UTSW |
10 |
82,061,160 (GRCm39) |
nonsense |
probably null |
|
|
R6649:Zfp938
|
UTSW |
10 |
82,061,232 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7992:Zfp938
|
UTSW |
10 |
82,061,777 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8211:Zfp938
|
UTSW |
10 |
82,062,419 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8313:Zfp938
|
UTSW |
10 |
82,061,422 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8963:Zfp938
|
UTSW |
10 |
82,061,287 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
X0066:Zfp938
|
UTSW |
10 |
82,061,931 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Posted On |
2014-02-04 |
Incidental Mutation