Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01815:Lrrc10b'

154376

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc10b

Ensembl Gene

ENSMUSG00000090291

Gene Name

leucine rich repeat containing 10B

Synonyms

SerdinR, Gm705, LOC278795

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

IGL01815

Quality Score

Status

Chromosome

Chromosomal Location

10432735-10434811 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 10434117 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 188 (D188G)

Ref Sequence

ENSEMBL: ENSMUSP00000132865 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076968] [ENSMUST00000169121] [ENSMUST00000171400]

AlphaFold

G3XA50

Predicted Effect

probably benign
Transcript: ENSMUST00000076968

SMART Domains

Protein: ENSMUSP00000076234
Gene: ENSMUSG00000024743

Domain	Start	End	E-Value	Type
transmembrane domain	18	40	N/A	INTRINSIC
C2	195	298	3.29e-25	SMART
low complexity region	305	318	N/A	INTRINSIC
C2	326	440	4.98e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000169121

SMART Domains

Protein: ENSMUSP00000127973
Gene: ENSMUSG00000024743

Domain	Start	End	E-Value	Type
transmembrane domain	17	39	N/A	INTRINSIC
low complexity region	104	121	N/A	INTRINSIC
C2	315	418	3.29e-25	SMART
low complexity region	425	438	N/A	INTRINSIC
C2	446	560	4.98e-25	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000171400
AA Change: D188G

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000132865
Gene: ENSMUSG00000090291
AA Change: D188G

Domain	Start	End	E-Value	Type
LRR	43	65	3.98e1	SMART
LRR	66	87	4.2e0	SMART
LRR	89	111	1.25e-1	SMART
LRR	135	156	1.41e1	SMART
LRR	158	181	6.96e0	SMART
low complexity region	257	263	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap3	A	G	4: 155,986,644 (GRCm39)	E324G	probably damaging	Het
Arhgap20	T	A	9: 51,757,468 (GRCm39)	Y487N	probably damaging	Het
Babam2	C	T	5: 31,859,442 (GRCm39)	A3V	possibly damaging	Het
Fat4	T	C	3: 38,942,922 (GRCm39)	L605P	probably damaging	Het
Frmpd1	A	G	4: 45,284,239 (GRCm39)	H1020R	probably benign	Het
Ighv1-53	T	A	12: 115,122,217 (GRCm39)	M53L	probably benign	Het
Lepr	A	T	4: 101,671,987 (GRCm39)	I1004F	possibly damaging	Het
Limd1	T	C	9: 123,308,801 (GRCm39)	S167P	probably benign	Het
Nlrp4e	T	C	7: 23,020,863 (GRCm39)	L450P	probably benign	Het
Or56b1	T	A	7: 104,285,552 (GRCm39)	Y224N	probably damaging	Het
Or5b104	A	T	19: 13,073,020 (GRCm39)		probably null	Het
Or7e165	A	G	9: 19,695,311 (GRCm39)	N294S	probably damaging	Het
Or7g21	G	T	9: 19,032,622 (GRCm39)	D121Y	probably damaging	Het
P2ry13	T	C	3: 59,117,121 (GRCm39)	N219S	probably benign	Het
Pcnx1	A	G	12: 82,037,325 (GRCm39)	D1861G	probably damaging	Het
Phlpp2	A	G	8: 110,666,491 (GRCm39)	I1007V	probably benign	Het
Ppp2r1a	A	G	17: 21,177,094 (GRCm39)	N211D	probably benign	Het
Psmd5	A	T	2: 34,742,783 (GRCm39)	F440L	probably benign	Het
Rpe65	T	A	3: 159,310,167 (GRCm39)		probably null	Het
Utrn	T	C	10: 12,528,460 (GRCm39)	T2172A	probably benign	Het
Vwa8	C	T	14: 79,435,717 (GRCm39)	T1809M	possibly damaging	Het
Wdr70	C	T	15: 7,916,805 (GRCm39)		probably null	Het

Other mutations in Lrrc10b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4927:Lrrc10b	UTSW	19	10,434,226 (GRCm39)	missense	probably damaging	0.99
R6303:Lrrc10b	UTSW	19	10,434,342 (GRCm39)	missense	probably benign	0.29
R6304:Lrrc10b	UTSW	19	10,434,342 (GRCm39)	missense	probably benign	0.29
R7326:Lrrc10b	UTSW	19	10,434,142 (GRCm39)	missense	possibly damaging	0.85

Posted On

2014-02-04