Incidental Mutation 'IGL01818:Oosp2'
ID154444
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp2
Ensembl Gene ENSMUSG00000055895
Gene Nameoocyte secreted protein 2
SynonymsLOC225922, Tmem122, Plac1l
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01818
Quality Score
Status
Chromosome19
Chromosomal Location11647279-11660559 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 11649689 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 90 (N90S)
Ref Sequence ENSEMBL: ENSMUSP00000113931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121793] [ENSMUST00000135994]
Predicted Effect probably benign
Transcript: ENSMUST00000069681
AA Change: N90S
SMART Domains Protein: ENSMUSP00000065120
Gene: ENSMUSG00000055895
AA Change: N90S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:Zona_pellucida 30 165 7.1e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121793
AA Change: N90S

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000113931
Gene: ENSMUSG00000055895
AA Change: N90S

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135994
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF529169 T C 9: 89,601,313 E677G probably damaging Het
Agrp T C 8: 105,567,386 D35G probably benign Het
C3ar1 T C 6: 122,850,419 N280D probably benign Het
Ccpg1 A G 9: 72,997,453 T15A probably damaging Het
Chmp7 A G 14: 69,719,167 V361A probably damaging Het
Dnmbp T A 19: 43,901,165 K721M probably damaging Het
Elmod3 T C 6: 72,586,507 E46G possibly damaging Het
Gm4922 T C 10: 18,784,953 D7G unknown Het
H2-T24 C A 17: 36,017,236 probably benign Het
Hal A T 10: 93,490,984 T161S probably damaging Het
Htr1d A G 4: 136,442,886 E142G probably benign Het
Mrps31 T C 8: 22,411,467 M1T probably null Het
Nckap1l T C 15: 103,478,282 L628P probably damaging Het
Pitpnm3 A G 11: 72,112,251 probably benign Het
Ppox A T 1: 171,280,744 I6K probably benign Het
Skint6 G T 4: 112,948,569 Q690K probably benign Het
Stat1 T C 1: 52,151,278 I564T probably damaging Het
Tiam1 T A 16: 89,867,704 I539F probably damaging Het
Tmem191c A G 16: 17,277,730 R35G possibly damaging Het
Trim30d A T 7: 104,472,060 C343S probably damaging Het
Trpm3 T C 19: 22,914,474 L736S probably damaging Het
Vmn2r73 T A 7: 85,869,901 probably benign Het
Other mutations in Oosp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Oosp2 APN 19 11647461 missense probably damaging 1.00
IGL01813:Oosp2 APN 19 11651483 missense probably benign 0.14
IGL02484:Oosp2 APN 19 11651483 missense probably benign 0.14
IGL03358:Oosp2 APN 19 11651569 nonsense probably null
R0938:Oosp2 UTSW 19 11651540 nonsense probably null
R1867:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R1944:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R1945:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R2149:Oosp2 UTSW 19 11649614 nonsense probably null
R4604:Oosp2 UTSW 19 11649683 missense probably benign 0.01
R4684:Oosp2 UTSW 19 11649653 missense probably damaging 0.98
R5034:Oosp2 UTSW 19 11651535 missense probably damaging 0.99
R6034:Oosp2 UTSW 19 11651515 missense probably damaging 1.00
R6034:Oosp2 UTSW 19 11651515 missense probably damaging 1.00
Posted On2014-02-04