Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01824:Zmym6'

154625

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym6

Ensembl Gene

ENSMUSG00000042408

Gene Name

zinc finger, MYM-type 6

Synonyms

9330177P20Rik, Zfp258, D4Wsu24e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01824

Quality Score

Status

Chromosome

Chromosomal Location

126971176-127018165 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 127002499 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 485 (V485F)

Ref Sequence

ENSEMBL: ENSMUSP00000092303 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046751] [ENSMUST00000094713]

AlphaFold

Q8BS54

Predicted Effect

probably damaging
Transcript: ENSMUST00000046751
AA Change: V577F

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000045366
Gene: ENSMUSG00000042408
AA Change: V577F

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	241	277	4.01e1	SMART
TRASH	349	385	2.46e1	SMART
TRASH	391	426	3.32e2	SMART
TRASH	434	472	2.91e-1	SMART
TRASH	478	513	9.99e0	SMART
low complexity region	602	612	N/A	INTRINSIC
low complexity region	642	656	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000094713
AA Change: V485F

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000092303
Gene: ENSMUSG00000042408
AA Change: V485F

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	262	293	6.03e2	SMART
TRASH	299	334	3.32e2	SMART
TRASH	342	380	2.91e-1	SMART
TRASH	386	421	9.99e0	SMART
low complexity region	510	520	N/A	INTRINSIC
low complexity region	550	564	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125160

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151461

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158357

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd17c	G	A	7: 83,800,497 (GRCm39)	R186C	probably benign	Het
Ankar	A	G	1: 72,690,886 (GRCm39)	V1196A	probably benign	Het
Asah1	A	T	8: 41,802,580 (GRCm39)		probably benign	Het
Chrm1	T	C	19: 8,656,494 (GRCm39)	W400R	probably damaging	Het
Cyp27a1	G	T	1: 74,775,040 (GRCm39)	E290*	probably null	Het
Dnah7a	T	C	1: 53,543,429 (GRCm39)	D2247G	probably benign	Het
Gins4	G	A	8: 23,724,784 (GRCm39)	Q57*	probably null	Het
Gli1	T	C	10: 127,172,396 (GRCm39)	D219G	probably benign	Het
Greb1	A	T	12: 16,761,717 (GRCm39)	C554*	probably null	Het
Gtf2ird2	T	C	5: 134,226,123 (GRCm39)		probably benign	Het
Ifna15	T	C	4: 88,476,020 (GRCm39)	R155G	probably benign	Het
Lck	T	A	4: 129,451,939 (GRCm39)	M14L	probably benign	Het
Megf6	A	G	4: 154,336,691 (GRCm39)	D322G	probably damaging	Het
Or4b1b	T	A	2: 90,112,263 (GRCm39)	I219F	probably damaging	Het
Pcdh18	A	T	3: 49,709,223 (GRCm39)	D697E	probably damaging	Het
Pnp	C	T	14: 51,188,870 (GRCm39)	T221I	probably damaging	Het
Ppl	A	G	16: 4,905,753 (GRCm39)	I1514T	probably damaging	Het
Scnn1g	A	G	7: 121,365,516 (GRCm39)	M523V	probably benign	Het
Sema4c	A	G	1: 36,592,110 (GRCm39)	Y246H	possibly damaging	Het
Slco1a5	T	A	6: 142,198,763 (GRCm39)	I301F	probably benign	Het
Srebf1	A	G	11: 60,094,957 (GRCm39)	S446P	probably benign	Het
Sys1	T	G	2: 164,305,225 (GRCm39)	L56R	probably damaging	Het
Trpc7	G	T	13: 56,937,535 (GRCm39)	Y585*	probably null	Het
Vmn2r110	T	A	17: 20,794,929 (GRCm39)	Y580F	probably benign	Het

Other mutations in Zmym6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00430:Zmym6	APN	4	126,995,742 (GRCm39)	nonsense	probably null
IGL00486:Zmym6	APN	4	127,017,978 (GRCm39)	utr 5 prime	probably benign
IGL01017:Zmym6	APN	4	126,982,152 (GRCm39)	missense	probably benign	0.00
IGL01385:Zmym6	APN	4	127,017,899 (GRCm39)	missense	probably benign	0.02
IGL01577:Zmym6	APN	4	126,999,223 (GRCm39)	missense	probably damaging	1.00
IGL01654:Zmym6	APN	4	127,017,519 (GRCm39)	missense	probably damaging	1.00
IGL01736:Zmym6	APN	4	127,002,437 (GRCm39)	missense	probably damaging	1.00
IGL01916:Zmym6	APN	4	127,017,549 (GRCm39)	missense	probably damaging	0.98
IGL01985:Zmym6	APN	4	126,994,541 (GRCm39)	missense	probably damaging	1.00
IGL02056:Zmym6	APN	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
IGL02477:Zmym6	APN	4	126,972,295 (GRCm39)	nonsense	probably null
IGL02754:Zmym6	APN	4	127,003,764 (GRCm39)	splice site	probably benign
IGL03344:Zmym6	APN	4	127,014,314 (GRCm39)	missense	probably damaging	1.00
IGL03412:Zmym6	APN	4	126,986,731 (GRCm39)	missense	probably damaging	1.00
R0335:Zmym6	UTSW	4	127,016,601 (GRCm39)	missense	probably damaging	1.00
R0448:Zmym6	UTSW	4	127,002,487 (GRCm39)	missense	probably benign	0.01
R0463:Zmym6	UTSW	4	127,016,565 (GRCm39)	missense	probably damaging	0.98
R0538:Zmym6	UTSW	4	127,017,162 (GRCm39)	missense	probably benign	0.21
R0789:Zmym6	UTSW	4	127,016,615 (GRCm39)	missense	possibly damaging	0.52
R0798:Zmym6	UTSW	4	126,997,316 (GRCm39)	missense	probably benign	0.00
R1311:Zmym6	UTSW	4	127,017,151 (GRCm39)	missense	probably damaging	1.00
R1351:Zmym6	UTSW	4	127,016,798 (GRCm39)	missense	probably benign	0.00
R1429:Zmym6	UTSW	4	127,017,672 (GRCm39)	missense	probably damaging	1.00
R1636:Zmym6	UTSW	4	127,017,560 (GRCm39)	missense	probably damaging	0.99
R1666:Zmym6	UTSW	4	127,016,652 (GRCm39)	missense	probably damaging	0.98
R1919:Zmym6	UTSW	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
R2058:Zmym6	UTSW	4	126,982,208 (GRCm39)	nonsense	probably null
R3957:Zmym6	UTSW	4	127,017,089 (GRCm39)	missense	possibly damaging	0.68
R3978:Zmym6	UTSW	4	127,017,348 (GRCm39)	missense	possibly damaging	0.71
R4417:Zmym6	UTSW	4	126,986,781 (GRCm39)	missense	probably damaging	1.00
R4801:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R4802:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R5052:Zmym6	UTSW	4	127,017,767 (GRCm39)	missense	possibly damaging	0.92
R5105:Zmym6	UTSW	4	127,017,551 (GRCm39)	missense	probably benign	0.33
R5217:Zmym6	UTSW	4	126,999,167 (GRCm39)	missense	possibly damaging	0.76
R5682:Zmym6	UTSW	4	126,998,200 (GRCm39)	missense	probably damaging	1.00
R5841:Zmym6	UTSW	4	126,994,463 (GRCm39)	missense	possibly damaging	0.71
R5991:Zmym6	UTSW	4	127,002,266 (GRCm39)	splice site	probably null
R6478:Zmym6	UTSW	4	127,017,176 (GRCm39)	missense	possibly damaging	0.86
R7014:Zmym6	UTSW	4	127,017,337 (GRCm39)	nonsense	probably null
R7287:Zmym6	UTSW	4	127,016,775 (GRCm39)	missense	possibly damaging	0.50
R7290:Zmym6	UTSW	4	127,017,294 (GRCm39)	missense	possibly damaging	0.73
R7371:Zmym6	UTSW	4	126,998,106 (GRCm39)	missense	probably damaging	1.00
R7967:Zmym6	UTSW	4	127,016,453 (GRCm39)	missense	probably benign	0.03
R8237:Zmym6	UTSW	4	127,016,544 (GRCm39)	missense	probably damaging	0.99
R8306:Zmym6	UTSW	4	127,016,355 (GRCm39)	missense	probably damaging	1.00
R8312:Zmym6	UTSW	4	127,017,627 (GRCm39)	missense	probably damaging	1.00
R9090:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9216:Zmym6	UTSW	4	127,002,500 (GRCm39)	missense	probably benign	0.00
R9271:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9695:Zmym6	UTSW	4	127,016,340 (GRCm39)	missense	probably benign
X0025:Zmym6	UTSW	4	127,016,143 (GRCm39)	missense	possibly damaging	0.60
X0067:Zmym6	UTSW	4	126,998,107 (GRCm39)	missense	probably damaging	1.00
Z1177:Zmym6	UTSW	4	127,017,590 (GRCm39)	missense	not run

Posted On

2014-02-04