Mutagenetix > Incidental Mutation

Incidental Mutation 'R0040:Scara5'

15487

Institutional Source

Beutler Lab

Gene Symbol

Scara5

Ensembl Gene

ENSMUSG00000022032

Gene Name

scavenger receptor class A, member 5

Synonyms

4933425F03Rik, 4932433F15Rik

MMRRC Submission

038334-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R0040 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

65903852-66002275 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 66000166 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000022610 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022610]

AlphaFold

Q8K299

Predicted Effect

probably benign
Transcript: ENSMUST00000022610

SMART Domains

Protein: ENSMUSP00000022610
Gene: ENSMUSG00000022032

Domain	Start	End	E-Value	Type
transmembrane domain	60	82	N/A	INTRINSIC
Pfam:Collagen	304	357	1.8e-8	PFAM
Pfam:Collagen	327	383	1.1e-8	PFAM
SR	389	489	5.5e-56	SMART

Coding Region Coverage

1x: 84.2%
3x: 77.3%
10x: 61.4%
20x: 43.8%

Validation Efficiency

96% (74/77)

MGI Phenotype

PHENOTYPE: Homozygous deletion of this gene results in decreased male fertility and lymphocytic infiltration of the stroma of various tissues, particularly in the lungs. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	G	6: 121,622,165 (GRCm39)	L356R	possibly damaging	Het
Antxr2	G	A	5: 98,086,284 (GRCm39)	T441I	possibly damaging	Het
Apcs	A	G	1: 172,722,023 (GRCm39)	Y108H	probably benign	Het
Arpp21	T	C	9: 111,976,477 (GRCm39)		probably benign	Het
Atcay	C	T	10: 81,046,353 (GRCm39)		probably null	Het
Bahcc1	A	G	11: 120,159,196 (GRCm39)	D141G	probably damaging	Het
Cacng5	A	T	11: 107,775,336 (GRCm39)	L11Q	probably damaging	Het
Ccdc73	T	C	2: 104,822,429 (GRCm39)	S793P	probably damaging	Het
Ceacam10	A	G	7: 24,477,689 (GRCm39)	Y68C	probably damaging	Het
Csmd3	G	A	15: 47,497,212 (GRCm39)	P3062S	probably damaging	Het
Dctn4	A	G	18: 60,677,114 (GRCm39)	N145D	possibly damaging	Het
Dusp12	A	G	1: 170,708,226 (GRCm39)	Y164H	probably damaging	Het
Fat1	A	G	8: 45,479,441 (GRCm39)	D2829G	probably damaging	Het
Fbxl13	T	C	5: 21,691,371 (GRCm39)	T671A	probably damaging	Het
Fndc3b	T	A	3: 27,610,266 (GRCm39)		probably null	Het
Gprc6a	T	A	10: 51,491,080 (GRCm39)	K819*	probably null	Het
Gucy2g	T	A	19: 55,205,734 (GRCm39)	T709S	possibly damaging	Het
Gxylt1	A	T	15: 93,152,436 (GRCm39)		probably benign	Het
Idh2	A	G	7: 79,747,570 (GRCm39)	S317P	probably damaging	Het
Ifi30	T	C	8: 71,216,421 (GRCm39)		probably null	Het
Ifna16	G	A	4: 88,594,867 (GRCm39)	A76V	probably benign	Het
Itpr2	C	T	6: 146,246,638 (GRCm39)	E1127K	probably damaging	Het
Kank4	A	G	4: 98,667,457 (GRCm39)	V330A	probably benign	Het
Kri1	T	C	9: 21,192,401 (GRCm39)	Y131C	probably damaging	Het
Krt71	T	A	15: 101,646,868 (GRCm39)	H280L	possibly damaging	Het
Lox	A	T	18: 52,653,898 (GRCm39)	H399Q	possibly damaging	Het
Mapt	A	G	11: 104,196,224 (GRCm39)	M446V	probably damaging	Het
Mpp7	A	T	18: 7,403,180 (GRCm39)		probably benign	Het
Mycbp2	A	G	14: 103,461,708 (GRCm39)	V1447A	probably benign	Het
Myl3	A	C	9: 110,596,997 (GRCm39)	D119A	probably damaging	Het
Myo1b	A	T	1: 51,821,148 (GRCm39)	I451N	probably damaging	Het
Nubp1	A	G	16: 10,238,981 (GRCm39)	T199A	probably damaging	Het
Olfml2b	A	G	1: 170,496,320 (GRCm39)	H317R	probably benign	Het
Pard3b	A	T	1: 62,676,979 (GRCm39)	Y1170F	probably damaging	Het
Pear1	T	C	3: 87,661,665 (GRCm39)	D536G	probably damaging	Het
Pira6	A	G	7: 4,284,482 (GRCm39)		noncoding transcript	Het
Pkhd1l1	T	A	15: 44,437,021 (GRCm39)	Y3460N	probably damaging	Het
Plxna2	G	T	1: 194,326,204 (GRCm39)	R46L	probably benign	Het
Rnf168	T	A	16: 32,096,991 (GRCm39)		probably null	Het
Rpl14	C	G	9: 120,401,167 (GRCm39)	F3L	possibly damaging	Het
Sh3rf1	T	A	8: 61,782,286 (GRCm39)	Y143N	possibly damaging	Het
Slc4a8	T	A	15: 100,687,727 (GRCm39)	I288N	probably damaging	Het
Synpr	G	A	14: 13,563,024 (GRCm38)	A86T	probably damaging	Het
Ttc38	C	A	15: 85,725,690 (GRCm39)	F184L	probably damaging	Het
Wdpcp	A	G	11: 21,661,638 (GRCm39)	I303M	probably damaging	Het
Zc3h12d	G	A	10: 7,743,678 (GRCm39)	A483T	probably benign	Het
Zfp106	C	A	2: 120,362,094 (GRCm39)	K1008N	probably damaging	Het
Zfp68	G	A	5: 138,606,041 (GRCm39)	T94I	probably benign	Het
Zfp867	C	T	11: 59,354,691 (GRCm39)	A213T	possibly damaging	Het
Zkscan3	A	T	13: 21,579,090 (GRCm39)		probably null	Het

Other mutations in Scara5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Scara5	APN	14	65,975,864 (GRCm39)	splice site	probably benign
IGL00772:Scara5	APN	14	65,908,011 (GRCm39)	utr 5 prime	probably benign
IGL01768:Scara5	APN	14	65,927,224 (GRCm39)	nonsense	probably null
IGL02081:Scara5	APN	14	65,968,104 (GRCm39)	missense	possibly damaging	0.96
IGL02280:Scara5	APN	14	65,968,227 (GRCm39)	missense	probably benign
IGL02795:Scara5	APN	14	65,968,129 (GRCm39)	missense	possibly damaging	0.72
IGL02887:Scara5	APN	14	66,000,278 (GRCm39)	missense	unknown
R0605:Scara5	UTSW	14	65,997,097 (GRCm39)	missense	possibly damaging	0.85
R0735:Scara5	UTSW	14	65,968,468 (GRCm39)	missense	possibly damaging	0.85
R0925:Scara5	UTSW	14	66,000,167 (GRCm39)	critical splice acceptor site	probably benign
R1575:Scara5	UTSW	14	65,968,314 (GRCm39)	missense	probably benign	0.18
R1746:Scara5	UTSW	14	65,968,539 (GRCm39)	missense	probably benign
R1968:Scara5	UTSW	14	65,927,249 (GRCm39)	missense	possibly damaging	0.73
R4455:Scara5	UTSW	14	66,000,196 (GRCm39)	missense	probably benign	0.01
R4547:Scara5	UTSW	14	65,908,023 (GRCm39)	missense	possibly damaging	0.72
R4779:Scara5	UTSW	14	65,968,198 (GRCm39)	missense	probably benign	0.03
R5218:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5316:Scara5	UTSW	14	65,927,264 (GRCm39)	missense	possibly damaging	0.73
R5331:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5332:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5366:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5367:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5368:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5369:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5417:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5418:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5420:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5447:Scara5	UTSW	14	65,997,111 (GRCm39)	frame shift	probably null
R5473:Scara5	UTSW	14	65,977,788 (GRCm39)	missense	possibly damaging	0.84
R5580:Scara5	UTSW	14	65,968,528 (GRCm39)	missense	probably benign	0.02
R7734:Scara5	UTSW	14	65,968,600 (GRCm39)	missense	possibly damaging	0.85
R7995:Scara5	UTSW	14	65,997,057 (GRCm39)	missense	possibly damaging	0.53
R8090:Scara5	UTSW	14	65,979,586 (GRCm39)	nonsense	probably null
R8308:Scara5	UTSW	14	65,927,234 (GRCm39)	missense	probably damaging	0.97
R9036:Scara5	UTSW	14	66,000,197 (GRCm39)	missense	probably benign	0.24

Posted On

2012-12-21