Incidental Mutation 'IGL01835:Tas2r139'
ID 154925
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r139
Ensembl Gene ENSMUSG00000047102
Gene Name taste receptor, type 2, member 139
Synonyms mt2r34, Tas2r39
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01835
Quality Score
Status
Chromosome 6
Chromosomal Location 42117870-42118829 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42118366 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 166 (N166I)
Ref Sequence ENSEMBL: ENSMUSP00000062919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057686]
AlphaFold Q7TQA5
Predicted Effect probably benign
Transcript: ENSMUST00000057686
AA Change: N166I

PolyPhen 2 Score 0.211 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000062919
Gene: ENSMUSG00000047102
AA Change: N166I

DomainStartEndE-ValueType
Pfam:TAS2R 13 311 2.5e-64 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,213,957 (GRCm39) M728K probably benign Het
2700049A03Rik T A 12: 71,213,955 (GRCm39) Y727* probably null Het
Adam23 T C 1: 63,582,278 (GRCm39) Y309H probably damaging Het
Ash2l C T 8: 26,329,868 (GRCm39) V97M probably damaging Het
Cyp4f13 A G 17: 33,149,588 (GRCm39) F83L probably benign Het
Dnah6 A T 6: 73,112,784 (GRCm39) S1607T probably damaging Het
Dock2 T A 11: 34,260,435 (GRCm39) M969L possibly damaging Het
Dse T A 10: 34,036,213 (GRCm39) probably benign Het
Dusp22 C T 13: 30,892,666 (GRCm39) probably null Het
F5 G A 1: 164,021,937 (GRCm39) V1471I probably benign Het
Gm14403 A T 2: 177,199,049 (GRCm39) E48D probably damaging Het
Gm6309 G A 5: 146,105,085 (GRCm39) A276V probably damaging Het
Icam4 A T 9: 20,941,086 (GRCm39) T113S probably damaging Het
Ipo5 T C 14: 121,163,650 (GRCm39) V236A probably benign Het
Mrc2 T G 11: 105,227,503 (GRCm39) F579V probably damaging Het
Myl4 T A 11: 104,468,279 (GRCm39) M1K probably null Het
Oas3 A T 5: 120,904,193 (GRCm39) C560* probably null Het
Or2w25 T C 11: 59,504,165 (GRCm39) V125A probably damaging Het
Or52e18 T C 7: 104,609,669 (GRCm39) N90S probably benign Het
Prlr G A 15: 10,329,129 (GRCm39) V535I probably damaging Het
Ptprd T C 4: 76,165,058 (GRCm39) T48A probably benign Het
Rasa4 A G 5: 136,131,461 (GRCm39) H485R possibly damaging Het
Rnf13 A T 3: 57,728,007 (GRCm39) H229L probably damaging Het
Rpap3 T C 15: 97,601,120 (GRCm39) D39G possibly damaging Het
Sec23ip T A 7: 128,357,035 (GRCm39) probably null Het
Sirpa T A 2: 129,457,484 (GRCm39) F186Y possibly damaging Het
Slc26a11 T C 11: 119,268,040 (GRCm39) Y473H probably benign Het
Slc36a2 T C 11: 55,053,559 (GRCm39) I360V probably benign Het
Spg11 G A 2: 121,918,705 (GRCm39) R975C probably benign Het
Sppl2b T A 10: 80,701,175 (GRCm39) I350N probably damaging Het
Trav14n-3 A G 14: 53,607,786 (GRCm39) T39A possibly damaging Het
Vmn2r61 A G 7: 41,950,015 (GRCm39) M812V probably benign Het
Vmn2r87 A C 10: 130,314,978 (GRCm39) F203V probably damaging Het
Vwde A C 6: 13,186,823 (GRCm39) V888G probably benign Het
Zbtb17 T C 4: 141,192,749 (GRCm39) probably null Het
Other mutations in Tas2r139
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00863:Tas2r139 APN 6 42,118,055 (GRCm39) missense probably damaging 1.00
IGL01593:Tas2r139 APN 6 42,117,891 (GRCm39) missense probably benign 0.01
IGL02990:Tas2r139 APN 6 42,118,038 (GRCm39) missense probably damaging 1.00
R0517:Tas2r139 UTSW 6 42,118,425 (GRCm39) missense probably damaging 0.98
R1106:Tas2r139 UTSW 6 42,118,479 (GRCm39) missense probably benign 0.36
R1352:Tas2r139 UTSW 6 42,117,874 (GRCm39) missense probably benign 0.28
R4352:Tas2r139 UTSW 6 42,118,689 (GRCm39) missense probably damaging 1.00
R4632:Tas2r139 UTSW 6 42,118,432 (GRCm39) missense probably damaging 1.00
R4785:Tas2r139 UTSW 6 42,118,218 (GRCm39) missense probably damaging 1.00
R4947:Tas2r139 UTSW 6 42,118,500 (GRCm39) missense possibly damaging 0.82
R5888:Tas2r139 UTSW 6 42,118,430 (GRCm39) missense probably damaging 1.00
R6796:Tas2r139 UTSW 6 42,118,526 (GRCm39) missense probably damaging 1.00
R8058:Tas2r139 UTSW 6 42,118,753 (GRCm39) missense probably benign 0.01
R8075:Tas2r139 UTSW 6 42,118,154 (GRCm39) missense probably benign 0.00
R8319:Tas2r139 UTSW 6 42,118,720 (GRCm39) missense probably benign 0.01
R9087:Tas2r139 UTSW 6 42,118,168 (GRCm39) missense probably damaging 1.00
R9185:Tas2r139 UTSW 6 42,118,099 (GRCm39) missense probably benign 0.25
R9803:Tas2r139 UTSW 6 42,118,066 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04