Incidental Mutation 'IGL01837:Dok3'
ID154998
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dok3
Ensembl Gene ENSMUSG00000035711
Gene Namedocking protein 3
Synonymsp62Dok-like protein
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL01837
Quality Score
Status
Chromosome13
Chromosomal Location55523231-55529296 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 55523570 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 396 (E396G)
Ref Sequence ENSEMBL: ENSMUSP00000153308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047877] [ENSMUST00000223563]
Predicted Effect probably damaging
Transcript: ENSMUST00000047877
AA Change: E396G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046695
Gene: ENSMUSG00000035711
AA Change: E396G

DomainStartEndE-ValueType
PH 7 125 3.54e-5 SMART
IRS 157 256 1.61e-41 SMART
PTBI 158 256 2.59e-24 SMART
low complexity region 273 284 N/A INTRINSIC
low complexity region 304 315 N/A INTRINSIC
low complexity region 358 376 N/A INTRINSIC
low complexity region 410 421 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000223563
AA Change: E396G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223944
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,408,697 F1372L probably damaging Het
Alcam T A 16: 52,253,168 N339I probably benign Het
Ankrd35 A C 3: 96,680,666 D141A probably damaging Het
Apc2 A G 10: 80,314,658 I1820V probably benign Het
Ccp110 T A 7: 118,725,461 probably null Het
Copa T A 1: 172,118,852 D954E probably benign Het
Csmd2 A T 4: 128,419,570 I1347F possibly damaging Het
Ddx10 A G 9: 53,229,198 I301T probably benign Het
Defb23 T A 2: 152,459,374 M93L probably benign Het
Dnah8 T C 17: 30,751,591 probably null Het
Eml6 T A 11: 29,777,055 M1318L probably benign Het
Foxm1 T A 6: 128,366,204 probably benign Het
Gm11992 A T 11: 9,061,266 R236W probably damaging Het
Gm12794 A G 4: 101,941,453 E207G probably damaging Het
Greb1 T C 12: 16,684,451 I1513V probably benign Het
Hivep3 A G 4: 120,094,562 E25G possibly damaging Het
Ighg2b C T 12: 113,306,445 E318K unknown Het
Itga4 T C 2: 79,315,005 S722P probably damaging Het
Kirrel3 G A 9: 35,034,928 R617H probably damaging Het
Mboat1 A T 13: 30,241,183 H409L possibly damaging Het
Naa15 A T 3: 51,443,948 K180* probably null Het
Nccrp1 A G 7: 28,546,766 S124P probably damaging Het
Nphp4 T C 4: 152,488,881 I92T probably damaging Het
Olfr214 C A 6: 116,556,846 Y140* probably null Het
Olfr61 G A 7: 140,638,211 C170Y probably damaging Het
Pkd1l3 A G 8: 109,630,166 D741G possibly damaging Het
Plcb2 C T 2: 118,711,926 probably null Het
Prm2 G A 16: 10,791,911 probably null Het
R3hdm1 C T 1: 128,186,760 Q184* probably null Het
Rgl1 A T 1: 152,549,150 N359K probably damaging Het
Rnf44 A G 13: 54,682,153 Y366H probably damaging Het
Rpap2 G A 5: 107,625,969 probably null Het
Ryr3 T C 2: 112,801,320 N2120S probably damaging Het
Samd8 A G 14: 21,774,959 probably benign Het
Sipa1 G T 19: 5,652,071 T937K probably damaging Het
Sos1 A T 17: 80,422,728 D707E probably damaging Het
Tas2r109 T C 6: 132,980,514 N151S probably benign Het
Try5 T C 6: 41,313,424 N42S probably benign Het
Ttn G T 2: 76,901,994 probably benign Het
Utp14b A G 1: 78,664,919 E178G probably damaging Het
Other mutations in Dok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02088:Dok3 APN 13 55524370 missense probably damaging 1.00
IGL02218:Dok3 APN 13 55523786 missense probably damaging 1.00
IGL02656:Dok3 APN 13 55528480 missense probably damaging 0.97
IGL03410:Dok3 APN 13 55524231 nonsense probably null
R0601:Dok3 UTSW 13 55524263 missense probably benign 0.16
R1306:Dok3 UTSW 13 55527448 nonsense probably null
R1749:Dok3 UTSW 13 55524355 frame shift probably null
R3684:Dok3 UTSW 13 55524493 missense probably damaging 1.00
R4863:Dok3 UTSW 13 55523457 missense probably damaging 1.00
R6195:Dok3 UTSW 13 55523576 missense probably benign 0.00
R7021:Dok3 UTSW 13 55524284 missense probably benign 0.00
Posted On2014-02-04