Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01796:Cdh23'

155358

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cdh23

Ensembl Gene

ENSMUSG00000012819

Gene Name

cadherin related 23 (otocadherin)

Synonyms

bob, sals, USH1D, ahl, mdfw, nmf252, 4930542A03Rik, nmf112, nmf181

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.428) question?

Stock #

IGL01796

Quality Score

Status

Chromosome

Chromosomal Location

60138527-60532269 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 60146916 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 2778 (Q2778L)

Ref Sequence

ENSEMBL: ENSMUSP00000101104 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073242] [ENSMUST00000105461] [ENSMUST00000105462] [ENSMUST00000105463] [ENSMUST00000105464]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000073242
AA Change: Q2779L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000072973
Gene: ENSMUSG00000012819
AA Change: Q2779L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	8.11e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1415	1.21e-18	SMART
CA	1440	1524	2.38e-26	SMART
CA	1549	1631	6.27e-26	SMART
CA	1656	1741	6.99e-24	SMART
CA	1765	1848	3.49e-24	SMART
CA	1872	1956	2.78e-18	SMART
CA	1984	2066	5.6e-14	SMART
CA	2090	2171	2.59e-27	SMART
CA	2195	2290	2.87e-11	SMART
CA	2317	2399	1.01e-20	SMART
CA	2423	2506	1.09e-25	SMART
CA	2530	2608	7.91e-23	SMART
CA	2634	2719	1.06e-23	SMART
CA	2750	2843	2e-10	SMART
Blast:CA	2867	2956	4e-51	BLAST
transmembrane domain	3067	3089	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105461
AA Change: Q2780L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101101
Gene: ENSMUSG00000012819
AA Change: Q2780L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	1.25e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1416	5.26e-19	SMART
CA	1441	1525	2.38e-26	SMART
CA	1550	1632	6.27e-26	SMART
CA	1657	1742	6.99e-24	SMART
CA	1766	1849	3.49e-24	SMART
CA	1873	1957	2.78e-18	SMART
CA	1985	2067	5.6e-14	SMART
CA	2091	2172	2.59e-27	SMART
CA	2196	2291	2.87e-11	SMART
CA	2318	2400	1.01e-20	SMART
CA	2424	2507	1.09e-25	SMART
CA	2531	2609	7.91e-23	SMART
CA	2635	2720	1.06e-23	SMART
CA	2751	2844	2e-10	SMART
Blast:CA	2868	2957	4e-51	BLAST
transmembrane domain	3068	3090	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105462
AA Change: Q2782L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000101102
Gene: ENSMUSG00000012819
AA Change: Q2782L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	261	349	2.03e-11	SMART
CA	374	461	8.11e-11	SMART
CA	485	562	1.04e-22	SMART
CA	586	672	3.55e-25	SMART
CA	696	779	2.04e-25	SMART
CA	803	891	5.03e-16	SMART
CA	915	996	1.05e-27	SMART
CA	1020	1103	1.99e-19	SMART
CA	1127	1209	6.94e-19	SMART
CA	1234	1314	1.99e-19	SMART
CA	1338	1418	1.21e-18	SMART
CA	1443	1527	2.38e-26	SMART
CA	1552	1634	6.27e-26	SMART
CA	1659	1744	6.99e-24	SMART
CA	1768	1851	3.49e-24	SMART
CA	1875	1959	2.78e-18	SMART
CA	1987	2069	5.6e-14	SMART
CA	2093	2174	2.59e-27	SMART
CA	2198	2293	2.87e-11	SMART
CA	2320	2402	1.01e-20	SMART
CA	2426	2509	1.09e-25	SMART
CA	2533	2611	7.91e-23	SMART
CA	2637	2722	1.06e-23	SMART
CA	2753	2846	2e-10	SMART
Blast:CA	2870	2959	4e-51	BLAST
transmembrane domain	3070	3092	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105463
AA Change: Q2780L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101103
Gene: ENSMUSG00000012819
AA Change: Q2780L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	458	1.25e-11	SMART
CA	482	559	1.04e-22	SMART
CA	583	669	3.55e-25	SMART
CA	693	776	2.04e-25	SMART
CA	800	888	5.03e-16	SMART
CA	912	993	1.05e-27	SMART
CA	1017	1100	1.99e-19	SMART
CA	1124	1206	6.94e-19	SMART
CA	1231	1311	1.99e-19	SMART
CA	1335	1416	5.26e-19	SMART
CA	1441	1525	2.38e-26	SMART
CA	1550	1632	6.27e-26	SMART
CA	1657	1742	6.99e-24	SMART
CA	1766	1849	3.49e-24	SMART
CA	1873	1957	2.78e-18	SMART
CA	1985	2067	5.6e-14	SMART
CA	2091	2172	2.59e-27	SMART
CA	2196	2291	2.87e-11	SMART
CA	2318	2400	1.01e-20	SMART
CA	2424	2507	1.09e-25	SMART
CA	2531	2609	7.91e-23	SMART
CA	2635	2720	1.06e-23	SMART
CA	2751	2844	2e-10	SMART
Blast:CA	2868	2957	4e-51	BLAST
transmembrane domain	3068	3090	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000105464
AA Change: Q2778L

PolyPhen 2 Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000101104
Gene: ENSMUSG00000012819
AA Change: Q2778L

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
CA	55	130	5.15e-13	SMART
CA	154	234	3.19e-18	SMART
CA	258	346	2.03e-11	SMART
CA	371	456	3.58e-12	SMART
CA	480	557	1.04e-22	SMART
CA	581	667	3.55e-25	SMART
CA	691	774	2.04e-25	SMART
CA	798	886	5.03e-16	SMART
CA	910	991	1.05e-27	SMART
CA	1015	1098	1.99e-19	SMART
CA	1122	1204	6.94e-19	SMART
CA	1229	1309	1.99e-19	SMART
CA	1333	1414	5.26e-19	SMART
CA	1439	1523	2.38e-26	SMART
CA	1548	1630	6.27e-26	SMART
CA	1655	1740	6.99e-24	SMART
CA	1764	1847	3.49e-24	SMART
CA	1871	1955	2.78e-18	SMART
CA	1983	2065	5.6e-14	SMART
CA	2089	2170	2.59e-27	SMART
CA	2194	2289	2.87e-11	SMART
CA	2316	2398	1.01e-20	SMART
CA	2422	2505	1.09e-25	SMART
CA	2529	2607	7.91e-23	SMART
CA	2633	2718	1.06e-23	SMART
CA	2749	2842	2e-10	SMART
Blast:CA	2866	2955	3e-51	BLAST
transmembrane domain	3066	3088	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128249

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151194

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153525

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
PHENOTYPE: Mutant mice exhibit circling behavior, tilting of the head and are deaf. Mice homozygous for a targeted knock-out exhibit abnormal outer hair cells morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	C	5: 125,590,273 (GRCm39)	Y511H	probably damaging	Het
Abca7	T	G	10: 79,849,743 (GRCm39)	Y1948D	probably damaging	Het
Adgrl2	C	A	3: 148,564,611 (GRCm39)	G319V	probably damaging	Het
Adgrv1	T	A	13: 81,715,461 (GRCm39)	D909V	probably benign	Het
Anapc16	T	C	10: 59,824,579 (GRCm39)	E119G	possibly damaging	Het
C1qtnf12	T	C	4: 156,050,886 (GRCm39)	V285A	possibly damaging	Het
Cbr1	A	C	16: 93,405,119 (GRCm39)	N89T	probably damaging	Het
Clca4c-ps	A	G	3: 144,595,340 (GRCm39)		noncoding transcript	Het
Cst9	T	C	2: 148,677,269 (GRCm39)	F47L	probably damaging	Het
Dqx1	T	C	6: 83,043,408 (GRCm39)		probably benign	Het
Dus4l	T	C	12: 31,692,794 (GRCm39)	S150G	probably benign	Het
E2f2	A	T	4: 135,907,728 (GRCm39)	K142*	probably null	Het
Eif2ak4	T	A	2: 118,276,785 (GRCm39)	H169Q	probably benign	Het
Fmo9	C	T	1: 166,490,904 (GRCm39)	A525T	probably benign	Het
Gm42878	T	C	5: 121,683,247 (GRCm39)	D6G	probably benign	Het
Igfals	A	G	17: 25,099,056 (GRCm39)	Y49C	probably damaging	Het
Il22b	T	C	10: 118,126,069 (GRCm39)	N176S	possibly damaging	Het
Ipo7	T	C	7: 109,629,055 (GRCm39)		probably benign	Het
Itga1	T	C	13: 115,121,657 (GRCm39)	E784G	probably damaging	Het
Jcad	G	T	18: 4,672,855 (GRCm39)	E206*	probably null	Het
Kif24	A	T	4: 41,392,978 (GRCm39)		probably benign	Het
Lrrc2	T	A	9: 110,809,886 (GRCm39)		probably null	Het
Ltbp1	A	G	17: 75,534,240 (GRCm39)		probably benign	Het
Man2c1	C	T	9: 57,045,244 (GRCm39)	T451I	possibly damaging	Het
Manba	T	A	3: 135,248,150 (GRCm39)	N346K	probably damaging	Het
Nell1	T	C	7: 49,825,964 (GRCm39)		probably benign	Het
Nfat5	T	C	8: 108,094,273 (GRCm39)	V744A	probably damaging	Het
Nms	T	C	1: 38,985,192 (GRCm39)	M98T	possibly damaging	Het
Nos1	A	T	5: 118,076,339 (GRCm39)	K1120*	probably null	Het
Or11g25	C	A	14: 50,722,998 (GRCm39)	Q28K	probably benign	Het
Plekho1	C	T	3: 95,898,147 (GRCm39)	R172H	probably damaging	Het
Pot1b	A	T	17: 55,976,750 (GRCm39)	C391S	possibly damaging	Het
Scn1a	G	A	2: 66,162,645 (GRCm39)		probably benign	Het
Sgce	T	G	6: 4,711,326 (GRCm39)	N149H	probably damaging	Het
Slc45a1	A	G	4: 150,728,426 (GRCm39)	W126R	probably damaging	Het
Slc9a1	G	A	4: 133,147,404 (GRCm39)		probably benign	Het
Tmem131l	T	A	3: 83,845,362 (GRCm39)	K423*	probably null	Het
Tnrc18	C	T	5: 142,750,642 (GRCm39)	E1444K	possibly damaging	Het
Tpp1	T	C	7: 105,396,857 (GRCm39)		probably benign	Het
Trip12	A	C	1: 84,705,999 (GRCm39)	S610R	probably benign	Het
Ushbp1	G	T	8: 71,840,076 (GRCm39)	A525E	probably benign	Het
Vmn2r106	A	T	17: 20,488,314 (GRCm39)	M695K	possibly damaging	Het
Vmn2r118	A	G	17: 55,915,585 (GRCm39)	I455T	probably benign	Het
Zbtb41	T	C	1: 139,370,621 (GRCm39)	F686S	probably damaging	Het

Other mutations in Cdh23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Cdh23	APN	10	60,359,327 (GRCm39)	missense	probably benign	0.03
IGL00429:Cdh23	APN	10	60,256,920 (GRCm39)	missense	probably damaging	0.97
IGL01014:Cdh23	APN	10	60,143,301 (GRCm39)	missense	probably damaging	0.99
IGL01284:Cdh23	APN	10	60,301,876 (GRCm39)	missense	possibly damaging	0.95
IGL01305:Cdh23	APN	10	60,148,403 (GRCm39)	missense	probably damaging	1.00
IGL01367:Cdh23	APN	10	60,146,566 (GRCm39)	missense	probably damaging	1.00
IGL01396:Cdh23	APN	10	60,220,848 (GRCm39)	missense	possibly damaging	0.93
IGL01412:Cdh23	APN	10	60,150,473 (GRCm39)	missense	probably damaging	1.00
IGL01461:Cdh23	APN	10	60,244,926 (GRCm39)	missense	possibly damaging	0.53
IGL01469:Cdh23	APN	10	60,433,504 (GRCm39)	missense	probably benign	0.03
IGL01695:Cdh23	APN	10	60,167,612 (GRCm39)	missense	probably benign	0.20
IGL01734:Cdh23	APN	10	60,139,292 (GRCm39)	missense	probably benign
IGL01767:Cdh23	APN	10	60,151,503 (GRCm39)	missense	probably damaging	1.00
IGL01843:Cdh23	APN	10	60,255,598 (GRCm39)	splice site	probably null
IGL02025:Cdh23	APN	10	60,220,922 (GRCm39)	missense	probably damaging	1.00
IGL02071:Cdh23	APN	10	60,359,339 (GRCm39)	missense	possibly damaging	0.93
IGL02160:Cdh23	APN	10	60,433,544 (GRCm39)	splice site	probably benign
IGL02175:Cdh23	APN	10	60,167,087 (GRCm39)	missense	possibly damaging	0.92
IGL02220:Cdh23	APN	10	60,140,903 (GRCm39)	missense	probably damaging	1.00
IGL02302:Cdh23	APN	10	60,159,302 (GRCm39)	missense	possibly damaging	0.87
IGL02331:Cdh23	APN	10	60,301,322 (GRCm39)	missense	probably damaging	0.99
IGL02452:Cdh23	APN	10	60,153,721 (GRCm39)	missense	probably damaging	0.99
IGL02499:Cdh23	APN	10	60,220,958 (GRCm39)	missense	probably damaging	1.00
IGL02548:Cdh23	APN	10	60,485,901 (GRCm39)	missense	probably benign	0.37
IGL02593:Cdh23	APN	10	60,301,774 (GRCm39)	splice site	probably benign
IGL02626:Cdh23	APN	10	60,227,580 (GRCm39)	missense	probably damaging	1.00
IGL02951:Cdh23	APN	10	60,147,143 (GRCm39)	missense	probably damaging	1.00
IGL03145:Cdh23	APN	10	60,212,593 (GRCm39)	missense	probably damaging	0.99
dee_dee	UTSW	10	60,143,835 (GRCm39)	nonsense	probably null
hersey	UTSW	10	60,143,815 (GRCm39)	missense	probably damaging	1.00
ANU22:Cdh23	UTSW	10	60,148,403 (GRCm39)	missense	probably damaging	1.00
IGL02980:Cdh23	UTSW	10	60,150,399 (GRCm39)	missense	probably damaging	1.00
PIT4362001:Cdh23	UTSW	10	60,301,237 (GRCm39)	missense	probably benign	0.15
R0013:Cdh23	UTSW	10	60,248,952 (GRCm39)	missense	possibly damaging	0.90
R0045:Cdh23	UTSW	10	60,366,757 (GRCm39)	missense	probably damaging	1.00
R0045:Cdh23	UTSW	10	60,366,757 (GRCm39)	missense	probably damaging	1.00
R0082:Cdh23	UTSW	10	60,148,366 (GRCm39)	missense	probably damaging	1.00
R0124:Cdh23	UTSW	10	60,143,835 (GRCm39)	nonsense	probably null
R0172:Cdh23	UTSW	10	60,155,411 (GRCm39)	missense	probably damaging	1.00
R0195:Cdh23	UTSW	10	60,152,838 (GRCm39)	missense	probably damaging	0.99
R0365:Cdh23	UTSW	10	60,215,094 (GRCm39)	missense	probably damaging	0.99
R0437:Cdh23	UTSW	10	60,246,576 (GRCm39)	missense	probably damaging	1.00
R0486:Cdh23	UTSW	10	60,222,725 (GRCm39)	missense	probably damaging	1.00
R0494:Cdh23	UTSW	10	60,152,375 (GRCm39)	splice site	probably benign
R0545:Cdh23	UTSW	10	60,167,070 (GRCm39)	missense	probably benign	0.06
R0619:Cdh23	UTSW	10	60,269,556 (GRCm39)	missense	probably damaging	1.00
R0647:Cdh23	UTSW	10	60,159,153 (GRCm39)	nonsense	probably null
R0647:Cdh23	UTSW	10	60,143,681 (GRCm39)	missense	probably damaging	0.99
R0730:Cdh23	UTSW	10	60,159,493 (GRCm39)	missense	probably damaging	0.99
R0880:Cdh23	UTSW	10	60,242,200 (GRCm39)	missense	possibly damaging	0.51
R0942:Cdh23	UTSW	10	60,246,639 (GRCm39)	missense	possibly damaging	0.67
R0989:Cdh23	UTSW	10	60,370,289 (GRCm39)	missense	probably damaging	0.99
R1017:Cdh23	UTSW	10	60,167,572 (GRCm39)	missense	probably damaging	1.00
R1173:Cdh23	UTSW	10	60,148,171 (GRCm39)	splice site	probably benign
R1449:Cdh23	UTSW	10	60,212,730 (GRCm39)	missense	probably damaging	1.00
R1456:Cdh23	UTSW	10	60,322,899 (GRCm39)	missense	possibly damaging	0.84
R1519:Cdh23	UTSW	10	60,215,122 (GRCm39)	missense	possibly damaging	0.92
R1532:Cdh23	UTSW	10	60,150,110 (GRCm39)	missense	probably damaging	0.99
R1559:Cdh23	UTSW	10	60,255,478 (GRCm39)	splice site	probably benign
R1704:Cdh23	UTSW	10	60,150,390 (GRCm39)	missense	probably damaging	1.00
R1711:Cdh23	UTSW	10	60,359,315 (GRCm39)	missense	probably benign	0.07
R1760:Cdh23	UTSW	10	60,161,855 (GRCm39)	missense	probably damaging	1.00
R1782:Cdh23	UTSW	10	60,324,321 (GRCm39)	missense	probably damaging	1.00
R1791:Cdh23	UTSW	10	60,227,505 (GRCm39)	missense	possibly damaging	0.89
R1803:Cdh23	UTSW	10	60,167,060 (GRCm39)	missense	probably damaging	1.00
R1857:Cdh23	UTSW	10	60,159,076 (GRCm39)	missense	probably damaging	1.00
R1874:Cdh23	UTSW	10	60,272,597 (GRCm39)	missense	possibly damaging	0.52
R1914:Cdh23	UTSW	10	60,159,349 (GRCm39)	missense	probably damaging	0.99
R1958:Cdh23	UTSW	10	60,246,652 (GRCm39)	missense	probably benign	0.02
R1964:Cdh23	UTSW	10	60,221,001 (GRCm39)	missense	probably benign	0.31
R1966:Cdh23	UTSW	10	60,159,361 (GRCm39)	missense	probably damaging	1.00
R1981:Cdh23	UTSW	10	60,214,530 (GRCm39)	missense	probably damaging	1.00
R2010:Cdh23	UTSW	10	60,150,006 (GRCm39)	missense	probably damaging	0.99
R2036:Cdh23	UTSW	10	60,301,822 (GRCm39)	missense	possibly damaging	0.52
R2038:Cdh23	UTSW	10	60,148,366 (GRCm39)	missense	probably damaging	1.00
R2044:Cdh23	UTSW	10	60,432,509 (GRCm39)	missense	possibly damaging	0.72
R2111:Cdh23	UTSW	10	60,141,362 (GRCm39)	missense	probably damaging	0.99
R2112:Cdh23	UTSW	10	60,141,362 (GRCm39)	missense	probably damaging	0.99
R2211:Cdh23	UTSW	10	60,301,783 (GRCm39)	missense	possibly damaging	0.92
R2261:Cdh23	UTSW	10	60,152,907 (GRCm39)	missense	probably damaging	1.00
R2262:Cdh23	UTSW	10	60,152,907 (GRCm39)	missense	probably damaging	1.00
R2306:Cdh23	UTSW	10	60,159,224 (GRCm39)	missense	probably damaging	1.00
R2344:Cdh23	UTSW	10	60,152,503 (GRCm39)	missense	probably damaging	1.00
R2857:Cdh23	UTSW	10	60,218,432 (GRCm39)	critical splice donor site	probably null
R2858:Cdh23	UTSW	10	60,218,432 (GRCm39)	critical splice donor site	probably null
R2859:Cdh23	UTSW	10	60,218,432 (GRCm39)	critical splice donor site	probably null
R2876:Cdh23	UTSW	10	60,143,275 (GRCm39)	missense	probably damaging	1.00
R3034:Cdh23	UTSW	10	60,244,789 (GRCm39)	splice site	probably benign
R3424:Cdh23	UTSW	10	60,212,660 (GRCm39)	missense	possibly damaging	0.76
R3699:Cdh23	UTSW	10	60,163,149 (GRCm39)	critical splice donor site	probably null
R3700:Cdh23	UTSW	10	60,163,149 (GRCm39)	critical splice donor site	probably null
R3950:Cdh23	UTSW	10	60,493,105 (GRCm39)	missense	probably benign	0.04
R3951:Cdh23	UTSW	10	60,493,105 (GRCm39)	missense	probably benign	0.04
R3952:Cdh23	UTSW	10	60,493,105 (GRCm39)	missense	probably benign	0.04
R4108:Cdh23	UTSW	10	60,246,601 (GRCm39)	missense	possibly damaging	0.51
R4114:Cdh23	UTSW	10	60,256,819 (GRCm39)	splice site	probably null
R4273:Cdh23	UTSW	10	60,146,940 (GRCm39)	missense	possibly damaging	0.69
R4284:Cdh23	UTSW	10	60,139,272 (GRCm39)	missense	possibly damaging	0.91
R4334:Cdh23	UTSW	10	60,220,838 (GRCm39)	missense	probably damaging	0.99
R4474:Cdh23	UTSW	10	60,146,865 (GRCm39)	missense	probably damaging	1.00
R4532:Cdh23	UTSW	10	60,370,202 (GRCm39)	missense	probably benign	0.32
R4597:Cdh23	UTSW	10	60,244,823 (GRCm39)	missense	probably damaging	1.00
R4604:Cdh23	UTSW	10	60,173,445 (GRCm39)	missense	possibly damaging	0.93
R4793:Cdh23	UTSW	10	60,167,129 (GRCm39)	missense	probably damaging	1.00
R4816:Cdh23	UTSW	10	60,244,856 (GRCm39)	missense	possibly damaging	0.93
R4833:Cdh23	UTSW	10	60,220,817 (GRCm39)	missense	probably damaging	1.00
R4840:Cdh23	UTSW	10	60,255,556 (GRCm39)	missense	possibly damaging	0.53
R4857:Cdh23	UTSW	10	60,227,563 (GRCm39)	missense	probably damaging	1.00
R4869:Cdh23	UTSW	10	60,212,713 (GRCm39)	missense	probably damaging	1.00
R4894:Cdh23	UTSW	10	60,173,630 (GRCm39)	missense	probably benign	0.04
R4940:Cdh23	UTSW	10	60,143,714 (GRCm39)	missense	probably damaging	0.98
R5020:Cdh23	UTSW	10	60,143,811 (GRCm39)	missense	probably damaging	0.99
R5026:Cdh23	UTSW	10	60,140,627 (GRCm39)	missense	possibly damaging	0.88
R5081:Cdh23	UTSW	10	60,272,586 (GRCm39)	missense	possibly damaging	0.89
R5138:Cdh23	UTSW	10	60,148,061 (GRCm39)	missense	probably damaging	1.00
R5236:Cdh23	UTSW	10	60,148,351 (GRCm39)	missense	probably damaging	1.00
R5361:Cdh23	UTSW	10	60,493,044 (GRCm39)	critical splice donor site	probably null
R5384:Cdh23	UTSW	10	60,173,541 (GRCm39)	missense	probably damaging	0.99
R5500:Cdh23	UTSW	10	60,150,090 (GRCm39)	missense	probably damaging	1.00
R5512:Cdh23	UTSW	10	60,370,165 (GRCm39)	splice site	probably null
R5673:Cdh23	UTSW	10	60,143,636 (GRCm39)	missense	probably damaging	1.00
R5720:Cdh23	UTSW	10	60,228,802 (GRCm39)	missense	possibly damaging	0.71
R5726:Cdh23	UTSW	10	60,243,259 (GRCm39)	missense	probably damaging	0.98
R5732:Cdh23	UTSW	10	60,167,096 (GRCm39)	missense	possibly damaging	0.80
R5739:Cdh23	UTSW	10	60,141,388 (GRCm39)	missense	probably damaging	0.99
R5760:Cdh23	UTSW	10	60,242,171 (GRCm39)	missense	probably damaging	0.99
R5793:Cdh23	UTSW	10	60,141,907 (GRCm39)	missense	probably damaging	1.00
R5880:Cdh23	UTSW	10	60,220,713 (GRCm39)	missense	probably damaging	1.00
R5905:Cdh23	UTSW	10	60,370,314 (GRCm39)	missense	probably damaging	0.98
R5907:Cdh23	UTSW	10	60,264,158 (GRCm39)	missense	probably damaging	1.00
R5910:Cdh23	UTSW	10	60,213,600 (GRCm39)	missense	possibly damaging	0.81
R5932:Cdh23	UTSW	10	60,228,763 (GRCm39)	missense	probably damaging	1.00
R5996:Cdh23	UTSW	10	60,249,356 (GRCm39)	missense	possibly damaging	0.85
R6015:Cdh23	UTSW	10	60,143,761 (GRCm39)	missense	probably damaging	0.97
R6020:Cdh23	UTSW	10	60,167,105 (GRCm39)	missense	probably damaging	1.00
R6023:Cdh23	UTSW	10	60,301,321 (GRCm39)	missense	probably damaging	1.00
R6028:Cdh23	UTSW	10	60,370,314 (GRCm39)	missense	probably damaging	0.98
R6066:Cdh23	UTSW	10	60,269,537 (GRCm39)	missense	probably damaging	1.00
R6137:Cdh23	UTSW	10	60,270,291 (GRCm39)	missense	probably damaging	0.96
R6211:Cdh23	UTSW	10	60,246,600 (GRCm39)	missense	possibly damaging	0.90
R6298:Cdh23	UTSW	10	60,262,451 (GRCm39)	nonsense	probably null
R6302:Cdh23	UTSW	10	60,140,872 (GRCm39)	missense	possibly damaging	0.74
R6338:Cdh23	UTSW	10	60,248,930 (GRCm39)	missense	probably damaging	1.00
R6356:Cdh23	UTSW	10	60,274,626 (GRCm39)	missense	probably damaging	1.00
R6441:Cdh23	UTSW	10	60,143,815 (GRCm39)	missense	probably damaging	1.00
R6714:Cdh23	UTSW	10	60,167,609 (GRCm39)	missense	possibly damaging	0.62
R6760:Cdh23	UTSW	10	60,141,947 (GRCm39)	missense	probably damaging	1.00
R6807:Cdh23	UTSW	10	60,214,650 (GRCm39)	missense	possibly damaging	0.95
R6855:Cdh23	UTSW	10	60,141,901 (GRCm39)	missense	possibly damaging	0.66
R6937:Cdh23	UTSW	10	60,322,893 (GRCm39)	missense	probably damaging	1.00
R6942:Cdh23	UTSW	10	60,274,635 (GRCm39)	missense	possibly damaging	0.93
R6961:Cdh23	UTSW	10	60,485,893 (GRCm39)	missense	probably benign	0.00
R7009:Cdh23	UTSW	10	60,173,085 (GRCm39)	missense	probably damaging	0.99
R7010:Cdh23	UTSW	10	60,366,770 (GRCm39)	missense	probably benign	0.03
R7032:Cdh23	UTSW	10	60,167,567 (GRCm39)	missense	probably damaging	1.00
R7046:Cdh23	UTSW	10	60,214,530 (GRCm39)	missense	probably damaging	1.00
R7111:Cdh23	UTSW	10	60,222,823 (GRCm39)	missense	probably damaging	1.00
R7196:Cdh23	UTSW	10	60,143,759 (GRCm39)	missense	probably damaging	0.99
R7198:Cdh23	UTSW	10	60,148,378 (GRCm39)	missense	possibly damaging	0.91
R7223:Cdh23	UTSW	10	60,167,596 (GRCm39)	missense	probably damaging	1.00
R7290:Cdh23	UTSW	10	60,212,620 (GRCm39)	missense	probably benign
R7335:Cdh23	UTSW	10	60,140,895 (GRCm39)	missense	probably damaging	1.00
R7340:Cdh23	UTSW	10	60,366,775 (GRCm39)	missense	probably benign	0.19
R7350:Cdh23	UTSW	10	60,246,689 (GRCm39)	missense	probably damaging	1.00
R7366:Cdh23	UTSW	10	60,151,471 (GRCm39)	nonsense	probably null
R7374:Cdh23	UTSW	10	60,153,679 (GRCm39)	missense	probably damaging	0.99
R7455:Cdh23	UTSW	10	60,142,003 (GRCm39)	missense	possibly damaging	0.82
R7537:Cdh23	UTSW	10	60,220,724 (GRCm39)	missense	probably benign	0.17
R7573:Cdh23	UTSW	10	60,159,329 (GRCm39)	missense	probably benign	0.17
R7578:Cdh23	UTSW	10	60,243,186 (GRCm39)	missense	probably benign	0.14
R7646:Cdh23	UTSW	10	60,140,931 (GRCm39)	missense	possibly damaging	0.95
R7703:Cdh23	UTSW	10	60,173,043 (GRCm39)	missense	probably damaging	1.00
R7763:Cdh23	UTSW	10	60,148,356 (GRCm39)	missense	probably damaging	1.00
R7797:Cdh23	UTSW	10	60,220,973 (GRCm39)	missense	probably benign	0.07
R7867:Cdh23	UTSW	10	60,150,390 (GRCm39)	missense	probably damaging	1.00
R7878:Cdh23	UTSW	10	60,149,979 (GRCm39)	missense	possibly damaging	0.69
R7915:Cdh23	UTSW	10	60,143,668 (GRCm39)	missense	probably damaging	0.97
R7922:Cdh23	UTSW	10	60,218,485 (GRCm39)	missense	probably benign	0.31
R7963:Cdh23	UTSW	10	60,171,967 (GRCm39)	missense	probably damaging	1.00
R7997:Cdh23	UTSW	10	60,432,518 (GRCm39)	missense	possibly damaging	0.81
R8167:Cdh23	UTSW	10	60,150,162 (GRCm39)	missense	probably benign	0.12
R8167:Cdh23	UTSW	10	60,173,472 (GRCm39)	missense	probably damaging	0.96
R8258:Cdh23	UTSW	10	60,151,435 (GRCm39)	missense	probably damaging	0.99
R8259:Cdh23	UTSW	10	60,151,435 (GRCm39)	missense	probably damaging	0.99
R8317:Cdh23	UTSW	10	60,272,568 (GRCm39)	missense	probably damaging	1.00
R8317:Cdh23	UTSW	10	60,147,037 (GRCm39)	critical splice donor site	probably null
R8326:Cdh23	UTSW	10	60,274,591 (GRCm39)	missense	possibly damaging	0.55
R8333:Cdh23	UTSW	10	60,150,390 (GRCm39)	missense	probably damaging	1.00
R8348:Cdh23	UTSW	10	60,167,507 (GRCm39)	missense	probably benign	0.43
R8366:Cdh23	UTSW	10	60,160,799 (GRCm39)	missense	probably benign
R8504:Cdh23	UTSW	10	60,274,618 (GRCm39)	missense	probably benign	0.00
R8676:Cdh23	UTSW	10	60,246,689 (GRCm39)	missense	probably damaging	1.00
R8781:Cdh23	UTSW	10	60,167,567 (GRCm39)	missense	probably damaging	1.00
R8785:Cdh23	UTSW	10	60,147,114 (GRCm39)	missense	probably damaging	1.00
R8788:Cdh23	UTSW	10	60,324,372 (GRCm39)	missense	probably damaging	1.00
R8802:Cdh23	UTSW	10	60,244,877 (GRCm39)	missense	probably benign	0.04
R8837:Cdh23	UTSW	10	60,160,755 (GRCm39)	missense	probably benign	0.28
R8863:Cdh23	UTSW	10	60,212,613 (GRCm39)	nonsense	probably null
R8889:Cdh23	UTSW	10	60,143,284 (GRCm39)	missense	probably damaging	0.97
R8892:Cdh23	UTSW	10	60,143,284 (GRCm39)	missense	probably damaging	0.97
R8921:Cdh23	UTSW	10	60,140,908 (GRCm39)	missense	probably damaging	0.99
R8980:Cdh23	UTSW	10	60,173,625 (GRCm39)	missense	probably benign	0.06
R9000:Cdh23	UTSW	10	60,140,277 (GRCm39)	missense	possibly damaging	0.82
R9043:Cdh23	UTSW	10	60,151,478 (GRCm39)	missense	probably benign	0.00
R9046:Cdh23	UTSW	10	60,218,303 (GRCm39)	intron	probably benign
R9070:Cdh23	UTSW	10	60,173,539 (GRCm39)	missense	probably benign
R9075:Cdh23	UTSW	10	60,153,541 (GRCm39)	missense	probably damaging	1.00
R9132:Cdh23	UTSW	10	60,270,283 (GRCm39)	splice site	probably benign
R9155:Cdh23	UTSW	10	60,249,485 (GRCm39)	missense	probably damaging	0.99
R9171:Cdh23	UTSW	10	60,161,810 (GRCm39)	missense	probably benign	0.00
R9179:Cdh23	UTSW	10	60,153,664 (GRCm39)	missense	probably benign	0.06
R9186:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9189:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9207:Cdh23	UTSW	10	60,243,210 (GRCm39)	missense	probably damaging	1.00
R9240:Cdh23	UTSW	10	60,215,044 (GRCm39)	missense	probably benign	0.00
R9244:Cdh23	UTSW	10	60,249,442 (GRCm39)	missense	possibly damaging	0.93
R9284:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9286:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9287:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9302:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9352:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9353:Cdh23	UTSW	10	60,143,306 (GRCm39)	missense	possibly damaging	0.54
R9423:Cdh23	UTSW	10	60,148,387 (GRCm39)	missense	probably damaging	1.00
R9513:Cdh23	UTSW	10	60,166,995 (GRCm39)	missense	probably damaging	0.99
R9577:Cdh23	UTSW	10	60,146,895 (GRCm39)	missense	probably damaging	1.00
R9598:Cdh23	UTSW	10	60,214,574 (GRCm39)	missense	probably benign	0.01
R9631:Cdh23	UTSW	10	60,243,168 (GRCm39)	missense	possibly damaging	0.49
R9652:Cdh23	UTSW	10	60,167,135 (GRCm39)	missense	probably damaging	1.00
R9725:Cdh23	UTSW	10	60,432,561 (GRCm39)	missense	probably benign	0.02
X0052:Cdh23	UTSW	10	60,220,913 (GRCm39)	missense	probably damaging	1.00
Z1088:Cdh23	UTSW	10	60,249,423 (GRCm39)	missense	probably benign	0.35
Z1176:Cdh23	UTSW	10	60,264,100 (GRCm39)	missense	probably benign
Z1176:Cdh23	UTSW	10	60,146,549 (GRCm39)	missense	probably damaging	1.00
Z1177:Cdh23	UTSW	10	60,270,393 (GRCm39)	critical splice acceptor site	probably null
Z1177:Cdh23	UTSW	10	60,159,334 (GRCm39)	missense	possibly damaging	0.80

Posted On

2014-02-04