Incidental Mutation 'IGL01796:Lrrc2'
ID155375
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc2
Ensembl Gene ENSMUSG00000032495
Gene Nameleucine rich repeat containing 2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL01796
Quality Score
Status
Chromosome9
Chromosomal Location110951545-110984066 bp(+) (GRCm38)
Type of Mutationunclassified (4117 bp from exon)
DNA Base Change (assembly) T to A at 110980818 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035076] [ENSMUST00000199891]
Predicted Effect probably benign
Transcript: ENSMUST00000035076
SMART Domains Protein: ENSMUSP00000035076
Gene: ENSMUSG00000032495

DomainStartEndE-ValueType
Blast:LRR 143 165 5e-7 BLAST
LRR_TYP 166 189 4.87e-4 SMART
LRR 236 258 1.41e1 SMART
LRR 259 282 2.27e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000196598
Predicted Effect probably null
Transcript: ENSMUST00000199891
SMART Domains Protein: ENSMUSP00000143305
Gene: ENSMUSG00000066319

DomainStartEndE-ValueType
zf-3CxxC 52 164 2.13e-52 SMART
low complexity region 356 404 N/A INTRINSIC
low complexity region 458 474 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,513,209 Y511H probably damaging Het
Abca7 T G 10: 80,013,909 Y1948D probably damaging Het
Adgrl2 C A 3: 148,858,975 G319V probably damaging Het
Adgrv1 T A 13: 81,567,342 D909V probably benign Het
Anapc16 T C 10: 59,988,757 E119G possibly damaging Het
C1qtnf12 T C 4: 155,966,429 V285A possibly damaging Het
Cbr1 A C 16: 93,608,231 N89T probably damaging Het
Cdh23 T A 10: 60,311,137 Q2778L probably benign Het
Clca4c-ps A G 3: 144,889,579 noncoding transcript Het
Cst9 T C 2: 148,835,349 F47L probably damaging Het
Dqx1 T C 6: 83,066,427 probably benign Het
Dus4l T C 12: 31,642,795 S150G probably benign Het
E2f2 A T 4: 136,180,417 K142* probably null Het
Eif2ak4 T A 2: 118,446,304 H169Q probably benign Het
Fmo9 C T 1: 166,663,335 A525T probably benign Het
Gm42878 T C 5: 121,545,184 D6G probably benign Het
Igfals A G 17: 24,880,082 Y49C probably damaging Het
Iltifb T C 10: 118,290,164 N176S possibly damaging Het
Ipo7 T C 7: 110,029,848 probably benign Het
Itga1 T C 13: 114,985,121 E784G probably damaging Het
Jcad G T 18: 4,672,855 E206* probably null Het
Kif24 A T 4: 41,392,978 probably benign Het
Ltbp1 A G 17: 75,227,245 probably benign Het
Man2c1 C T 9: 57,137,960 T451I possibly damaging Het
Manba T A 3: 135,542,389 N346K probably damaging Het
Nell1 T C 7: 50,176,216 probably benign Het
Nfat5 T C 8: 107,367,641 V744A probably damaging Het
Nms T C 1: 38,946,111 M98T possibly damaging Het
Nos1 A T 5: 117,938,274 K1120* probably null Het
Olfr741 C A 14: 50,485,541 Q28K probably benign Het
Plekho1 C T 3: 95,990,835 R172H probably damaging Het
Pot1b A T 17: 55,669,750 C391S possibly damaging Het
Scn1a G A 2: 66,332,301 probably benign Het
Sgce T G 6: 4,711,326 N149H probably damaging Het
Slc45a1 A G 4: 150,643,969 W126R probably damaging Het
Slc9a1 G A 4: 133,420,093 probably benign Het
Tmem131l T A 3: 83,938,055 K423* probably null Het
Tnrc18 C T 5: 142,764,887 E1444K possibly damaging Het
Tpp1 T C 7: 105,747,650 probably benign Het
Trip12 A C 1: 84,728,278 S610R probably benign Het
Ushbp1 G T 8: 71,387,432 A525E probably benign Het
Vmn2r106 A T 17: 20,268,052 M695K possibly damaging Het
Vmn2r118 A G 17: 55,608,585 I455T probably benign Het
Zbtb41 T C 1: 139,442,883 F686S probably damaging Het
Other mutations in Lrrc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02243:Lrrc2 APN 9 110970057 missense probably damaging 1.00
IGL02715:Lrrc2 APN 9 110970114 missense probably damaging 1.00
IGL02793:Lrrc2 APN 9 110979627 critical splice donor site probably null
IGL02958:Lrrc2 APN 9 110962673 critical splice donor site probably null
R0255:Lrrc2 UTSW 9 110980898 missense possibly damaging 0.87
R0472:Lrrc2 UTSW 9 110962617 missense probably benign 0.00
R0909:Lrrc2 UTSW 9 110962673 critical splice donor site probably null
R1575:Lrrc2 UTSW 9 110979487 missense probably benign 0.07
R1619:Lrrc2 UTSW 9 110960973 missense probably benign 0.00
R1669:Lrrc2 UTSW 9 110981650 missense probably damaging 0.99
R1778:Lrrc2 UTSW 9 110980840 missense probably benign
R1914:Lrrc2 UTSW 9 110980939 missense probably damaging 1.00
R2165:Lrrc2 UTSW 9 110979577 missense possibly damaging 0.78
R3792:Lrrc2 UTSW 9 110966517 nonsense probably null
R3793:Lrrc2 UTSW 9 110966517 nonsense probably null
R4499:Lrrc2 UTSW 9 110962645 missense probably benign 0.11
R4683:Lrrc2 UTSW 9 110962546 missense possibly damaging 0.95
R4693:Lrrc2 UTSW 9 110970093 missense probably damaging 1.00
R4723:Lrrc2 UTSW 9 110970160 critical splice donor site probably null
R5033:Lrrc2 UTSW 9 110980919 missense probably damaging 0.98
R5935:Lrrc2 UTSW 9 110966561 missense probably benign 0.17
R6269:Lrrc2 UTSW 9 110980949 missense probably damaging 1.00
R6645:Lrrc2 UTSW 9 110970107 missense probably damaging 1.00
R6855:Lrrc2 UTSW 9 110953182 intron probably null
Posted On2014-02-04