Incidental Mutation 'IGL01797:Zfp268'
ID 155383
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp268
Ensembl Gene ENSMUSG00000078502
Gene Name zinc finger protein 268
Synonyms Gm13212
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.401) question?
Stock # IGL01797
Quality Score
Status
Chromosome 4
Chromosomal Location 145311770-145351915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145347241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 48 (N48K)
Ref Sequence ENSEMBL: ENSMUSP00000112918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097794] [ENSMUST00000105739] [ENSMUST00000119718]
AlphaFold B1ASQ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000097794
AA Change: N48K

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000095402
Gene: ENSMUSG00000078502
AA Change: N48K

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000105739
AA Change: N48K

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000101365
Gene: ENSMUSG00000078502
AA Change: N48K

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
ZnF_C2H2 406 428 1.58e-3 SMART
ZnF_C2H2 434 456 3.39e-3 SMART
ZnF_C2H2 462 484 1.06e-4 SMART
ZnF_C2H2 490 512 1.58e-3 SMART
ZnF_C2H2 518 540 3.39e-3 SMART
ZnF_C2H2 546 568 3.39e-3 SMART
ZnF_C2H2 574 596 3.39e-3 SMART
ZnF_C2H2 602 624 3.39e-3 SMART
ZnF_C2H2 630 652 1.06e-4 SMART
ZnF_C2H2 658 680 1.58e-3 SMART
ZnF_C2H2 686 708 3.39e-3 SMART
ZnF_C2H2 714 736 1.3e-4 SMART
ZnF_C2H2 742 764 1.3e-4 SMART
ZnF_C2H2 770 792 4.79e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119718
AA Change: N48K

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112918
Gene: ENSMUSG00000078502
AA Change: N48K

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
internal_repeat_1 141 211 2.19e-13 PROSPERO
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
low complexity region 320 335 N/A INTRINSIC
low complexity region 350 357 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180968
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T C 7: 120,113,760 (GRCm39) V877A probably benign Het
Clcn2 T C 16: 20,531,511 (GRCm39) I178V probably damaging Het
Cnbp A G 6: 87,822,542 (GRCm39) probably benign Het
Coq8a A T 1: 179,997,284 (GRCm39) probably null Het
Dctn2 A G 10: 127,113,182 (GRCm39) D244G possibly damaging Het
Dync1h1 T A 12: 110,618,630 (GRCm39) probably null Het
Efcab15 T C 11: 103,089,794 (GRCm39) Y381C probably damaging Het
Faiml T C 9: 99,116,442 (GRCm39) K83E probably damaging Het
Fdx1 A T 9: 51,854,925 (GRCm39) C159* probably null Het
Fgd3 A T 13: 49,443,065 (GRCm39) V169E probably damaging Het
Ice1 G T 13: 70,772,065 (GRCm39) T51K probably damaging Het
Iqca1 A C 1: 90,072,541 (GRCm39) probably null Het
Jup C A 11: 100,272,498 (GRCm39) probably benign Het
Krt84 A G 15: 101,436,915 (GRCm39) V373A possibly damaging Het
Ndst4 T A 3: 125,476,802 (GRCm39) M9K probably damaging Het
Nomo1 T C 7: 45,706,086 (GRCm39) V480A probably damaging Het
Nsun5 A G 5: 135,404,225 (GRCm39) H344R probably damaging Het
Or13a21 A G 7: 139,998,931 (GRCm39) Y252H probably damaging Het
Or1e1f A T 11: 73,855,644 (GRCm39) D70V probably damaging Het
Pjvk T C 2: 76,487,883 (GRCm39) probably benign Het
Prkaa1 G A 15: 5,198,187 (GRCm39) D159N probably damaging Het
Sap130 T A 18: 31,831,721 (GRCm39) I736N probably damaging Het
Tlcd1 A G 11: 78,071,160 (GRCm39) probably null Het
Tpp1 T C 7: 105,398,459 (GRCm39) I286V probably benign Het
Ttll5 T A 12: 86,003,371 (GRCm39) I1069K possibly damaging Het
Ttn T G 2: 76,540,257 (GRCm39) E34243A possibly damaging Het
Uqcr10 A C 11: 4,654,179 (GRCm39) I43S possibly damaging Het
Ush2a T A 1: 187,995,706 (GRCm39) M159K probably damaging Het
Vmn2r121 G A X: 123,041,048 (GRCm39) probably benign Het
Vmn2r30 T A 7: 7,337,195 (GRCm39) D147V probably benign Het
Xntrpc T C 7: 101,739,753 (GRCm39) I559T possibly damaging Het
Other mutations in Zfp268
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02678:Zfp268 APN 4 145,349,067 (GRCm39) missense probably damaging 1.00
IGL03035:Zfp268 APN 4 145,348,802 (GRCm39) missense possibly damaging 0.77
BB008:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
BB018:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R0090:Zfp268 UTSW 4 145,349,195 (GRCm39) nonsense probably null
R0904:Zfp268 UTSW 4 145,348,745 (GRCm39) missense possibly damaging 0.95
R1617:Zfp268 UTSW 4 145,350,877 (GRCm39) utr 3 prime probably benign
R1851:Zfp268 UTSW 4 145,350,820 (GRCm39) unclassified probably benign
R1864:Zfp268 UTSW 4 145,348,998 (GRCm39) missense possibly damaging 0.92
R2093:Zfp268 UTSW 4 145,349,139 (GRCm39) missense probably benign 0.02
R2132:Zfp268 UTSW 4 145,350,803 (GRCm39) unclassified probably benign
R2240:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
R4177:Zfp268 UTSW 4 145,347,225 (GRCm39) missense probably damaging 1.00
R4584:Zfp268 UTSW 4 145,343,747 (GRCm39) critical splice donor site probably null
R4991:Zfp268 UTSW 4 145,348,904 (GRCm39) missense probably benign 0.31
R5164:Zfp268 UTSW 4 145,348,775 (GRCm39) missense probably damaging 1.00
R6175:Zfp268 UTSW 4 145,350,811 (GRCm39) unclassified probably benign
R6176:Zfp268 UTSW 4 145,350,628 (GRCm39) nonsense probably null
R6498:Zfp268 UTSW 4 145,349,459 (GRCm39) missense probably damaging 0.98
R6984:Zfp268 UTSW 4 145,347,186 (GRCm39) missense probably damaging 1.00
R7134:Zfp268 UTSW 4 145,349,375 (GRCm39) missense possibly damaging 0.93
R7931:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R8017:Zfp268 UTSW 4 145,349,138 (GRCm39) missense probably benign 0.28
R8282:Zfp268 UTSW 4 145,349,547 (GRCm39) missense possibly damaging 0.94
R9320:Zfp268 UTSW 4 145,349,156 (GRCm39) missense possibly damaging 0.77
R9358:Zfp268 UTSW 4 145,349,613 (GRCm39) missense possibly damaging 0.79
R9435:Zfp268 UTSW 4 145,349,045 (GRCm39) missense
V5622:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
Z1176:Zfp268 UTSW 4 145,349,538 (GRCm39) missense possibly damaging 0.83
Posted On 2014-02-04