Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01798:Gm10377'

155416

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10377

Ensembl Gene

ENSMUSG00000095226

Gene Name

predicted gene 10377

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01798

Quality Score

Status

Chromosome

Chromosomal Location

42614525-42619892 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42614864 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 167 (I167K)

Ref Sequence

ENSEMBL: ENSMUSP00000098260 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100695]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000100695
AA Change: I167K

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000098260
Gene: ENSMUSG00000095226
AA Change: I167K

Domain	Start	End	E-Value	Type
Pfam:Takusan	10	88	5.5e-20	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	T	C	9: 57,163,921 (GRCm39)	I818V	probably benign	Het
Adam22	A	C	5: 8,282,604 (GRCm39)		probably null	Het
Afap1	T	A	5: 36,093,026 (GRCm39)		probably null	Het
Aunip	G	T	4: 134,250,722 (GRCm39)	K222N	possibly damaging	Het
Ccnt1	A	G	15: 98,442,122 (GRCm39)	V382A	probably benign	Het
Clip1	T	C	5: 123,721,612 (GRCm39)	D1123G	probably damaging	Het
Cxcr1	T	A	1: 74,231,759 (GRCm39)	I88F	possibly damaging	Het
Duox2	A	C	2: 122,112,389 (GRCm39)	Y1266D	probably damaging	Het
Elk4	T	A	1: 131,945,592 (GRCm39)	S157T	possibly damaging	Het
Erc1	T	C	6: 119,597,298 (GRCm39)	T1004A	possibly damaging	Het
Fah	T	C	7: 84,238,837 (GRCm39)	N336S	probably benign	Het
Glg1	A	T	8: 111,919,332 (GRCm39)	S253T	possibly damaging	Het
Hipk1	A	T	3: 103,668,875 (GRCm39)	I507N	probably damaging	Het
Hnf1a	T	C	5: 115,091,732 (GRCm39)	E357G	probably damaging	Het
Ighv1-22	A	T	12: 114,710,298 (GRCm39)	L10H	probably damaging	Het
Igkv6-23	A	G	6: 70,237,574 (GRCm39)	Y56H	probably damaging	Het
Lyrm9	A	G	11: 78,728,955 (GRCm39)	I56V	probably damaging	Het
Ncam1	G	T	9: 49,419,907 (GRCm39)	T804K	probably damaging	Het
Nfu1	T	A	6: 86,992,605 (GRCm39)	I73K	probably damaging	Het
Ruvbl2	A	G	7: 45,071,587 (GRCm39)	L432P	probably damaging	Het
Tcf3	T	C	10: 80,249,043 (GRCm39)	T527A	probably benign	Het
Tle1	T	C	4: 72,055,385 (GRCm39)	D432G	probably damaging	Het

Other mutations in Gm10377

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7371:Gm10377	UTSW	14	42,614,853 (GRCm39)	missense	probably benign
R8261:Gm10377	UTSW	14	42,616,664 (GRCm39)	critical splice donor site	probably null

Posted On

2014-02-04