Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01804:Tnfaip8l1'

155629

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tnfaip8l1

Ensembl Gene

ENSMUSG00000044469

Gene Name

tumor necrosis factor, alpha-induced protein 8-like 1

Synonyms

2600017J23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01804

Quality Score

Status

Chromosome

Chromosomal Location

56469477-56480955 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 56479214 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 168 (S168N)

Ref Sequence

ENSEMBL: ENSMUSP00000076961 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019723] [ENSMUST00000077788]

AlphaFold

Q8K288

Predicted Effect

probably benign
Transcript: ENSMUST00000019723

SMART Domains

Protein: ENSMUSP00000019723
Gene: ENSMUSG00000019579

Domain	Start	End	E-Value	Type
Pfam:UPF0556	11	166	4.8e-82	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000077788
AA Change: S168N

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000076961
Gene: ENSMUSG00000044469
AA Change: S168N

Domain	Start	End	E-Value	Type
Pfam:DUF758	4	184	5.8e-75	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195950

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,315,342 (GRCm39)	N1860D	probably benign	Het
Abca2	T	A	2: 25,336,637 (GRCm39)	C2248S	probably damaging	Het
Adamts16	G	A	13: 70,949,080 (GRCm39)	Q194*	probably null	Het
Cetn3	A	T	13: 81,932,779 (GRCm39)	K13*	probably null	Het
Cldn18	T	A	9: 99,580,901 (GRCm39)	K116*	probably null	Het
Cntn5	T	A	9: 9,831,542 (GRCm39)	I613F	probably damaging	Het
Cyp46a1	A	G	12: 108,321,745 (GRCm39)	I324V	probably benign	Het
Ddb1	A	C	19: 10,590,382 (GRCm39)	E303A	probably damaging	Het
Dnajc2	A	G	5: 21,962,361 (GRCm39)	V539A	probably damaging	Het
Dock2	T	A	11: 34,212,433 (GRCm39)	Y1236F	probably benign	Het
Dpf1	T	A	7: 29,015,926 (GRCm39)	C383S	probably damaging	Het
Edc4	T	A	8: 106,617,289 (GRCm39)	I1052N	possibly damaging	Het
Ehmt1	A	G	2: 24,681,966 (GRCm39)	L1243P	probably damaging	Het
Exoc6b	A	G	6: 84,885,148 (GRCm39)	S264P	probably damaging	Het
Gbx2	T	C	1: 89,856,703 (GRCm39)	E229G	probably benign	Het
Hip1r	T	A	5: 124,139,613 (GRCm39)		probably null	Het
Lig1	A	G	7: 13,043,131 (GRCm39)	K859E	probably benign	Het
Ly6g6f	T	C	17: 35,300,146 (GRCm39)	D234G	possibly damaging	Het
Mmp11	G	T	10: 75,764,304 (GRCm39)	L54I	probably benign	Het
Naip5	A	T	13: 100,358,092 (GRCm39)	L1048Q	probably damaging	Het
Or4c122	C	A	2: 89,079,566 (GRCm39)	M157I	probably benign	Het
Or6k14	A	G	1: 173,927,401 (GRCm39)	I126V	probably damaging	Het
Or7g12	T	A	9: 18,900,136 (GRCm39)	M284K	probably benign	Het
Or8g17	T	C	9: 38,930,697 (GRCm39)	I47V	probably benign	Het
Pappa2	T	C	1: 158,764,089 (GRCm39)	D474G	probably benign	Het
Plxna1	A	G	6: 89,306,628 (GRCm39)	Y1401H	probably damaging	Het
Prrg4	T	A	2: 104,663,035 (GRCm39)	E190D	probably damaging	Het
Rnf213	T	C	11: 119,333,092 (GRCm39)	F2767S	probably damaging	Het
Scgb1b2	T	A	7: 30,991,155 (GRCm39)		probably benign	Het
Sec31a	A	G	5: 100,523,065 (GRCm39)		probably null	Het
Slc12a4	A	G	8: 106,671,033 (GRCm39)	S1014P	probably damaging	Het
Spns2	A	T	11: 72,348,130 (GRCm39)	I279N	possibly damaging	Het
Spta1	A	T	1: 174,071,746 (GRCm39)	H2242L	probably benign	Het
Tcaf3	T	A	6: 42,574,063 (GRCm39)	I50F	probably damaging	Het
Trak1	C	T	9: 121,271,751 (GRCm39)		probably benign	Het
Trpv4	A	T	5: 114,782,847 (GRCm39)	N38K	possibly damaging	Het
Ube2o	T	C	11: 116,435,199 (GRCm39)	T530A	probably benign	Het
Vmn2r2	A	G	3: 64,041,677 (GRCm39)	V346A	possibly damaging	Het
Vmn2r86	A	C	10: 130,288,858 (GRCm39)	D214E	probably damaging	Het
Wwc1	C	A	11: 35,732,751 (GRCm39)	D986Y	probably damaging	Het
Xdh	T	C	17: 74,199,754 (GRCm39)	D1184G	probably damaging	Het

Other mutations in Tnfaip8l1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01710:Tnfaip8l1	APN	17	56,478,782 (GRCm39)	missense	probably benign	0.38
IGL02323:Tnfaip8l1	APN	17	56,479,009 (GRCm39)	missense	probably damaging	1.00
R0521:Tnfaip8l1	UTSW	17	56,478,727 (GRCm39)	missense	probably damaging	1.00
R2426:Tnfaip8l1	UTSW	17	56,479,030 (GRCm39)	missense	probably benign	0.01
R5737:Tnfaip8l1	UTSW	17	56,478,950 (GRCm39)	missense	probably benign	0.00
R5966:Tnfaip8l1	UTSW	17	56,478,799 (GRCm39)	missense	probably benign	0.02
R7366:Tnfaip8l1	UTSW	17	56,478,897 (GRCm39)	missense	probably damaging	0.98
R8500:Tnfaip8l1	UTSW	17	56,478,749 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04