Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01805:Hmgb4'

155660

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hmgb4

Ensembl Gene

ENSMUSG00000048686

Gene Name

high-mobility group box 4

Synonyms

1700001F22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.131) question?

Stock #

IGL01805

Quality Score

Status

Chromosome

Chromosomal Location

128154005-128154688 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

G to T at 128154015 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000138958 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053830] [ENSMUST00000184063]

AlphaFold

Q6P8W9

Predicted Effect

probably benign
Transcript: ENSMUST00000053830

SMART Domains

Protein: ENSMUSP00000059625
Gene: ENSMUSG00000048686

Domain	Start	End	E-Value	Type
HMG	8	80	7.01e-17	SMART
HMG	92	162	3.99e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129619

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131581

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144298

Predicted Effect

probably benign
Transcript: ENSMUST00000184063

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019D03Rik	T	C	1: 52,964,677 (GRCm39)	D17G	possibly damaging	Het
Adam28	G	T	14: 68,879,540 (GRCm39)	S169R	probably benign	Het
Aox1	T	C	1: 58,120,672 (GRCm39)	M855T	possibly damaging	Het
Apc	C	A	18: 34,451,271 (GRCm39)	N2688K	probably benign	Het
Arhgap23	T	A	11: 97,383,428 (GRCm39)		probably benign	Het
Bpifa6	A	G	2: 153,826,832 (GRCm39)	T66A	probably benign	Het
C1qtnf1	T	A	11: 118,338,993 (GRCm39)	L221Q	probably damaging	Het
Ccdc175	T	A	12: 72,176,003 (GRCm39)		probably benign	Het
Ccl1	C	A	11: 82,068,958 (GRCm39)	M26I	possibly damaging	Het
Dnah10	T	A	5: 124,860,985 (GRCm39)	F2123I	probably damaging	Het
Fancm	T	C	12: 65,160,635 (GRCm39)		probably null	Het
Fstl4	C	A	11: 53,077,184 (GRCm39)	A647E	probably damaging	Het
Hr	A	T	14: 70,802,737 (GRCm39)		probably benign	Het
Ilrun	C	T	17: 27,986,880 (GRCm39)		probably benign	Het
Kcna4	G	T	2: 107,126,843 (GRCm39)	V526L	probably damaging	Het
Mas1	T	C	17: 13,061,117 (GRCm39)	Y102C	probably damaging	Het
Mucl3	T	A	17: 35,948,535 (GRCm39)	T355S	possibly damaging	Het
Mul1	C	T	4: 138,166,974 (GRCm39)	P343S	possibly damaging	Het
Obscn	T	C	11: 59,023,422 (GRCm39)	S652G	probably damaging	Het
Or8g55	T	C	9: 39,785,075 (GRCm39)	F168S	probably damaging	Het
Pjvk	A	T	2: 76,487,858 (GRCm39)	N250I	probably benign	Het
Pkd2	T	C	5: 104,630,959 (GRCm39)	I461T	probably benign	Het
Psen2	T	C	1: 180,057,403 (GRCm39)		probably null	Het
Ralb	T	C	1: 119,403,725 (GRCm39)	E81G	probably benign	Het
Slc15a4	T	C	5: 127,685,900 (GRCm39)	T261A	possibly damaging	Het
Vmn2r77	G	A	7: 86,460,395 (GRCm39)	V574M	probably benign	Het
Xrn2	A	G	2: 146,870,063 (GRCm39)	I251V	probably damaging	Het
Zfp974	G	A	7: 27,611,689 (GRCm39)		probably benign	Het

Other mutations in Hmgb4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00559:Hmgb4	APN	4	128,154,082 (GRCm39)	missense	probably benign	0.00
IGL01701:Hmgb4	APN	4	128,154,166 (GRCm39)	missense	probably benign	0.01
IGL02752:Hmgb4	APN	4	128,154,134 (GRCm39)	missense	probably damaging	0.97
IGL02945:Hmgb4	APN	4	128,154,387 (GRCm39)	nonsense	probably null
IGL03210:Hmgb4	APN	4	128,154,535 (GRCm39)	missense	probably benign	0.18
R0012:Hmgb4	UTSW	4	128,154,518 (GRCm39)	missense	probably damaging	0.99
R0012:Hmgb4	UTSW	4	128,154,518 (GRCm39)	missense	probably damaging	0.99
R2178:Hmgb4	UTSW	4	128,154,275 (GRCm39)	missense	probably damaging	1.00
R6565:Hmgb4	UTSW	4	128,154,388 (GRCm39)	missense	probably benign	0.29
R7454:Hmgb4	UTSW	4	128,154,199 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04